2006
DOI: 10.1590/s0102-86502006000400002
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Abstract: The data confirm that age is related to delay in liver regeneration in rats.

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Cited by 30 publications
(34 citation statements)
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“…However, we observed more mitotic hepatocytes and PCNA-positive hepatic nuclei (an index of mitosis) in PW rats than in YA rats at 72 HPE. The association of hepatocyte mitosis with age has been noted previously [1,16].…”
Section: Discussionmentioning
confidence: 79%
“…However, we observed more mitotic hepatocytes and PCNA-positive hepatic nuclei (an index of mitosis) in PW rats than in YA rats at 72 HPE. The association of hepatocyte mitosis with age has been noted previously [1,16].…”
Section: Discussionmentioning
confidence: 79%
“…Aging is associated with a reduced regenerative potential in a number of different tissues like skeletal muscle, bone, liver and macrophages (immune system) (27)(28)(29). This poses a threat to the adaptive capacity of these tissues and the whole organism.…”
Section: Discussionmentioning
confidence: 99%
“…23 In humans, no comparative studies regarding regeneration rate after hepatectomy in elderly versus younger patients have been performed, but Biondo-Simoes et al recently showed a relevant delay in regeneration rate after major hepatectomy in elderly compared to younger rats. 24 Slower regeneration rates might well explain the higher in-hospital mortality, mostly due to liver insufficiency and sepsis, in patients over 60 years of age.…”
Section: Discussionmentioning
confidence: 99%