Omeprazole and misoprostol for preventing gastric mucosa effects caused by indomethacin and celecoxib in rats

Abstract

The indomethacin on the applied concentration causes a great number of macroscopic and microscopic injuries to gastric mucosa of rats when compared to celecoxib which does not cause lesions. Omeprazole and misoprostol on the applied concentrations do not present macroscopic and microscopic effectiveness on the gastric cytoprotection when applying indomethacin. Considering the microscopic analysis of the average of the edema, the group of animals, which was given misoprostol as cytoprotection, presented a lower average compared to the group which was given omeprazole.

Evaluation of the Gastroprotective Effect of Misoprostol, Chitosan and Their Combination on Indomethacin Induced Gastric Ulcer in Rats.

“…Misoprostol produced an increase in mucin production which was seen in the present study and it is also reported to increase bicarbonate and decreased acid secretion. [6] As the cytoprotective effect of misoprostol is well documented, [19] it is not yet known if this effect involves antioxidant potential. However, misoprostol in this study decreased MDA in the serum and in gastric tissue.…”

“…Drugs were administered by oral gavage using modified insulin syringes. Since the body weights of animals ranged from (197-205 g), fixed doses of the indometacin were given [6] as follow: indometacin 25mg/rat, by suspending one capsule of indometacin (Indylon 25mg, Medochemie, Cyprus), in 1 ml distilled water, and misoprostol tablet (Cytotec 200 µg, Searle, UK), suspended in 10ml distilled water, and administered in a dose of 20 µg /rat. Chitosan was prepared locally from shrimp shell wastes according to the method of Weska et al [7] This yielded high molecular weight (HMW) chitosan, then low molecular weight (LMW) chitosan was obtained according to the method of Yong et al [8] Chitosan was tested by infrared spectrophotometry.…”

Study of the antiulcer activity of dry extract of garden cabbage on a model of subchronic gastric ulcer

“…In recent years, to reduce complications due to NSAIDs propose to combine proton pump inhibitors with a synthetic analogue of prostaglandin E1, misoprostol, the use of which is limited to serious adverse reactions (diarrhea, arrhythmia, bronchospasm) and insufficiently studied mucoprotective rebamipide [20,21].…”

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“…The PGE1 (misoprostol) and PGE2 analogous have been studied clinically. It has been proved that they could significantly decrease the acid and bicarbonate secretion and increase mucosal regeneration and cell proliferation 18 and this may occur via an effect on epithelial regeneration and stimulation or modulation of the factors involved in ulcer healing such as angiogenesis, epithelial cell regeneration, wound contraction, and blood flow 13 .…”