Efeito do tamoxifeno no perfil das proteínas plasmáticas em condição de diabetes mellitus tipo 1

Silva, Teresa Cristina P.; Mota, Saul B.; Almeida, Maria Margareth C.; Ferreira, Elaine Cristina S.; Ururahy, Marcela Abbott Galvão; Bezerra, João Felipe; Pereira, Ney Moura Lemos; Ramos, Ana Maria de Oliveira; Almeida, Maria das Graças; Rezende, Adriana Augusto de

doi:10.1590/s0102-86502005000700016

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…The reduction in total plasma protein is expected in acute infl ammatory reaction cases (Silva et al, 2005) and is consistent with the fi ndings in Ribeiro et al (2010). Globulin, albumin, and fi brinogen are the major plasma proteins and were comparatively decreased in LPS-challenged piglets (P < 0.001).…”

Section: Acute Phase Responsesupporting

confidence: 91%

Effect of CLA on performance and immune response of weanling piglets1

Moraes

Ribeiro

Kessler

et al. 2012

Journal of Animal Science

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An experiment was conducted to evaluate the effect of CLA on the immune response and performance of piglets when subjected to an immune challenge. A total of 32 weanling pigs (17 to 23 d of age) with an initial BW of 8.9 kg were allotted to a 3 × 2 factorial arrangement of treatments. There were 3 levels of dietary CLA (0%, 1%, and 2%) and 2 levels of lipopolysaccharide (LPS) challenge (unchallenged and challenged). Challenged pigs were challenged on d 7 and 21. On d 4 and 18, all pigs were inoculated with BSA for assessment of IgG production. There was no difference in growth performance among piglets receiving different CLA supplementation levels. However, LPS-challenged piglets had poorer BW (P < 0.05), ADFI (P < 0.01), and ADG (P < 0.001) compared with the control group at d 35 postweaning. Lipopolysaccharide-challenged piglets also had increased respiratory rate (P < 0.001) and rectal temperature (P < 0.001), and decreased plasma proteins, hematocrit, and white blood cell counts (P < 0.05). Production of IgG against BSA was increased in the 1% CLA supplementation group (P < 0.001), indicating that CLA has an immunomodulatory effect. Supplementation with CLA did not affect lymphocyte proliferation, percentage of CD4(+) and CD8(+) cells, plasma proteins, red and white blood cell count, respiratory rate, or rectal temperature after LPS challenge. Although CLA supplementation did not influence growth performance or certain immune system measurements, the increased IgG titers with 1% CLA dietary supplementation indicate that it has a beneficial effect on the humoral immune system of weaned piglets.

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Section: Acute Phase Responsesupporting

confidence: 91%

Effect of CLA on performance and immune response of weanling piglets1

Moraes

Ribeiro

Kessler

et al. 2012

Journal of Animal Science

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“…Este fármaco apresenta ação agonista em determinados tecidos, como o endometrial, aumentando significativamente o risco de desenvolvimento de cânceres de útero (2 a 7 vezes) e hepático (metabolismo lipoprotéico associado ao câncer hepático e esteatose), e apresenta ação antagonista na mama. Outros efeitos colaterais incluem embolia pulmonar, trombose venosa profunda e distúrbios oculares, como retinopatia e opacidade corneal (DE LIMA et al, 2003;SILVA et al, 2005;SOUZA, 2013). Distúrbios uterinos benignos, como hiperplasias e pólipos, também ocorrem em cerca de 40 a 50% das mulheres no período pós-menopausa que fazem uso do tamoxifeno (NEVAN;VERGOTE, 2000;VOSSE et al, 2002).…”

Section: Tabela 8 -unclassified

Nanopartículas de PLA e PLA-PEG contendo tamoxifeno: preparação, caracterização e avaliação in vitro e in vivo

Oliveira¹

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, pela orientação, dedicação, confiança, amizade, exemplo profissional e contribuição científica ao longo da realização deste trabalho. À Drª. Marina Claro de Souza, grande amiga, pela parceria, colaboração e revisão deste trabalho. Obrigada pela amizade, apoio, incentivo, minuciosa revisão e valiosa contribuição em todos os trabalhos. Obrigada também por todo o auxílio, sem medir esforços, nos momentos difíceis que passei. A você, minha eterna gratidão e admiração. Aos pós-graduandos do laboratório de Tecnologia Farmacêutica da FCFRP-USP. M.Sc. Josimar O. Eloy pela importante contribuição nesta Tese e artigos científicos, bem como sua colaboração na execução de experimentos. M.Sc. Juliana Palma Abriatta Barcelos, pela colaboração na execução de experimentos da fase final, pela amizade, carinho e incentivo. Ao farmacêutico José Orestes Del Ciampo, do Laboratório de Tecnologia Farmacêutica, pela contribuição e pelas análises de tamanho das partículas. Ao biólogo Henrique Diniz pelas análises de calorimetria diferencial exploratória e análise termogravimétrica. À Dr a. Fabíola Garcia, especialista de laboratório. Aos três, agradeço pela amizade e por todas as contribuições diretas e indiretas ao meu trabalho. Ao Prof. Dr. Roberto S. Santana, da FCFRP-USP, por disponibilizar o espectrofotômetro infravermelho. Ao técnico de laboratório Clóvis R. da Silva Jr. pela execução das análises. Ao Prof. Dr. João Luis C. Lopes, da FCFRP-USP, pelo auxílio na interpretação dos espectros de absorção no infravermelho. À Profª. Drª. Vera Lucia Lanchote, da FCFRP-USP, pelos esclarecimentos sobre análise de amostras biológicas e por ter fornecido gentilmente o padrão interno utilizado no método bioanalítico.

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Liver iron overload induced by tamoxifen in diabetic and non-diabetic female Wistar rats

et al. 2007

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Tamoxifen (TX), a drug used in the treatment of breast cancer, may cause hepatic changes in some patients. The consequences of its use on the liver tissues of rats with or without diabetes mellitus (DM) have not been fully explored. The purpose of this study was to evaluate the correlation between plasma hepatic enzyme levels and the presence of iron overload in the hepatic tissue of female Wistar rats with or without streptozotocin-induced DM and using TX. Female rats were studied in control groups: C-0 (non-drug users), C-V (sorbitol vehicle only) and C-TX (using TX). DM (diabetic non-drug users) and DM-TX (diabetics using TX) were the test groups. Sixty days after induced DM, blood samples were collected for glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST) alkaline phosphatase (ALP) and bilirubin measures. Hepatic fragments were processed and stained with hematoxylin and eosin, Masson's trichrome, Perls. The hepatic iron content was quantified by atomic absorption spectrometry. AST, ALT and ALP levels were significantly elevated in the DM and DM-TX groups, with unchanged bilirubin levels. Liver iron overload using Perls stain and atomic absorption spectrometry were observed exclusively in groups C-TX and DM-TX. There was positive correlation between AST, ALT and ALP levels and microscopic hepatic siderosis intensity in group DM-TX. In conclusion, TX administration is associated with liver siderosis in diabetic and non-diabetic rats. In addition, TX induced liver iron overload with unaltered hepatic function in non-diabetic rats and may be a useful tool for investigating the biological control of iron metabolism.

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Efeito do tamoxifeno no perfil das proteínas plasmáticas em condição de diabetes mellitus tipo 1

Cited by 5 publications

References 15 publications

Effect of CLA on performance and immune response of weanling piglets1

Effect of CLA on performance and immune response of weanling piglets1

Nanopartículas de PLA e PLA-PEG contendo tamoxifeno: preparação, caracterização e avaliação in vitro e in vivo

Liver iron overload induced by tamoxifen in diabetic and non-diabetic female Wistar rats

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