Effects of the polypropylene mesh implanted through inguinotomy in the spermatic funiculus, epididium and testis of dogs

Goldenberg, Alberto; Paula, Joaquim Ferreira de

doi:10.1590/s0102-86502005000600012

Cited by 24 publications

(14 citation statements)

References 13 publications

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“…A histopathological study of inflammatory reactions triggered by the polypropylene mesh is best assessed 90 days after implantation, as shown by other studies [19,20,25,26]. Therefore, the present study design defined groups according to the exposure to polypropylene mesh, at 90 and 120 days after surgery.…”

Section: Discussionmentioning

confidence: 99%

Histopathological alterations of the vas deferens in rats exposed to polypropylene mesh

et al. 2007

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OBJECTIVE To assess the histological and physiological effects of polypropylene mesh for inguinal herniorraphy, as it can cause lesions in the vas deferens in 0.3–2.0%, leading to infertility, and induces an inflammatory process and adjacent fibrosis, strengthening the posterior inguinal wall. MATERIALS AND METHODS In all, 40 male albino rats (3 months old) had bilateral vas deferens dissection followed by mesh implantation on one side; the contralateral side was used as the control. The rats were killed 90 (group 1) and 120 (group 2) days later, and the vas deferens, epididymides and testicles assessed histopathologically. RESULTS There was a foreign‐body reaction after mesh implantation, but not in the controls. The mean lumen dilatation in regions proximal to the mesh in groups 1 and 2 was 0.468 and 0.371 mm2, respectively, and all the sections had spermatozoids. The mean dilatation in control groups 1 and 2 was 0.239 and 0.170 mm2, respectively, with spermatozoids present in 58% and 75%, respectively (significant, P < 0.05). In group 1 the wall thickness of mesh‐implanted segments reduced to 0.177 mm, and in segments proximal to the mesh to 0.099 mm; the control segment was 0.298 mm (P < 0.05). In group 2 the mean thickness of mesh‐implanted and proximal segments was 0.134 and 0.224 mm, respectively, while in the control it was 0.284 mm (not significant). There was loss of mucosal folding in all segments proximal to the mesh but not in the control. The epididymides and testicles were unchanged. CONCLUSION Polypropylene mesh induces a foreign‐body reaction, with histological changes in the vas deferens that cause functional obstruction, with dilatation and spermatozoid repression.

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Section: Discussionmentioning

confidence: 99%

Histopathological alterations of the vas deferens in rats exposed to polypropylene mesh

et al. 2007

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“…They concluded that there were changes in testosterone levels and in testicular volume in the group operated using TEP, in comparison with the group operated using the Lichtenstein technique. Goldenberg and De Paula 18 carried out an experimental study to observe the effects of a polypropylene mesh implanted by means of inguinotomy, on the spermatic funiculus. They used 18 dogs distributed into three groups: group A (n= 7), left side with mesh and right side without mesh; group B (n=7), left side without mesh and right side with mesh; and group C (n= 4), without surgical manipulation, i.e.…”

Section: Introductionmentioning

confidence: 99%

Prospective study on the effects of a polypropylene prosthesis on testicular volume and arterial flow in patients undergoing surgical correction for inguinal hernia

2007

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Purpose:To evaluate testicular volume and arterial flow in patients undergoing surgical correction for inguinal hernia, with polypropylene prosthesis. Methods: This was an observational prospective clinical study on 39 male patients with unilateral inguinal hernia of types III A and III B according to the Nyhus classification who underwent surgical correction with implantation of a polypropylene prosthesis by means of the Lichtenstein technique. The patients were evaluated using Doppler ultrasound before the operation and selectively at the third and sixth months after the operation. The variables studied were testicular volume, systolic and diastolic velocity, resistance index and pulsatility index. Results: No statistically significant alterations in the variables studied were observed over the course of time: testicular volume (p= 0.197); systolic velocity (p= 0.257); diastolic velocity (p= 0.554); resistance index (p= 0.998); and pulsatility index (p= 0.582). Conclusion: No alteration in testicular volume and arterial flow over a six-month period was observed among patients who underwent surgical correction for inguinal hernia using a polypropylene prothesis. Key words: Testis. Surgical Mesh. Hernia, Inguinal. RESUMO Objetivo:Avaliar o volume testicular e o fluxo na artéria testicular em pacientes operados de inguinal com prótese de polipropileno. Métodos: Estudo clínico prospectivo observacional em 39 pacientes do sexo masculino portadores de hérnia inguinal tipo III A e III B na classificação de Nyhus os quais foram submetidos a hernioplastia inguinal com implantação de prótese de polipropileno com a técnica de Lichtenstein. Os pacientes foram avaliados com ultra-sonografia Doppler no pré-operatório; no 3º mês e no 6º mês de pós-operatório. As variáveis estudadas foram: volume testicular; velocidade sistólica e diastólica, o índice de resistividade e o índice de pulsatilidade. Resultados: Não se observou alterações estatisticamente significantes nas variáveis ao longo do tempo: volume testicular (p=0,197); velocidade sistólica (p=0,257); velocidade diastólica (p=0,554); índice de resistividade (p=0,998); índice de pulsatilidade (p=0,582). Conclusão: Não se observou alteração no volume testicular e no fluxo sanguíneo da artéria testicular após seis meses nos pacientes submetidos à correção cirúrgica de hérnia inguinal com prótese de polipropileno.. Descritores: Testículo. Telas Cirúrgicas. Hérnia Inguinal. -ORIGINAL ARTICLE

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“…In addition, cryptorchidism or even epididymitis may eliminate the contralateral reproductive contribution 14 . From the works of Goldenberg et al 6 , and Goldenberg and De Paula 15 , it was clear that the inflammatory reaction provoked by the prosthesis extends to the spermatic cord and the vas deferens in much greater intensity when compared to the simple surgical manipulation without prosthesis implantation.…”

Section: ■ Discussionmentioning

confidence: 99%

Prospective ultrasonographic study of blood flow and testicular volume in patients submitted to surgical repair of inguinal hernia without using prosthesis

David

Goldenberg

2018

Acta Cir. Bras.

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Prospective ultrasonographic study of blood flow and testicular volume in patients submitted to surgical repair of inguinal hernia without using prosthesis 1 AbstractPurpose: To evaluate the behavior of arterial circulation and testicular volume in patients submitted to conventional inguinal hernia repair without the use of a synthetic prosthesis to reinforce the posterior wall. Methods: A prospective observational clinical trial was performed on 26 male patients with unilateral inguinal hernia types I and II by the Nyhus classification, who underwent surgical correction using the modified Bassini technique. Bilateral Doppler ultrasonography was performed preoperatively, at the third and at the sixth postoperative month. The studied variables were: systolic peak velocity (SPV), diastolic peak velocity (DPV), resistance index (RI), pulsatility index (PI) and testicular volume.

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Effects of the polypropylene mesh implanted through inguinotomy in the spermatic funiculus, epididium and testis of dogs

Abstract: The polypropylene mesh, when in contact with the spermatic funiculus of dogs, causes a more intense chronic inflammatory reaction and a significant reduction in the diameter of the lumen of the deferent duct.

Cited by 24 publications

References 13 publications

Histopathological alterations of the vas deferens in rats exposed to polypropylene mesh

Histopathological alterations of the vas deferens in rats exposed to polypropylene mesh

Prospective study on the effects of a polypropylene prosthesis on testicular volume and arterial flow in patients undergoing surgical correction for inguinal hernia

Prospective ultrasonographic study of blood flow and testicular volume in patients submitted to surgical repair of inguinal hernia without using prosthesis

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