2005
DOI: 10.1590/s0102-86502005000500003
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Abstract: No correlation was found between tumor expression of p53 and bcl-2 and the TNM staging, recurrence, survival and cancer-related mortality in colorectal adenocarcinoma.

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Cited by 16 publications
(11 citation statements)
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“…The specific mortality was not statistically significant when correlated with the immunohistochemical expressions separately and together. This was similar to the findings of Lustosa et al (19) , who also studied p53 and bcl-2 separately and together.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…The specific mortality was not statistically significant when correlated with the immunohistochemical expressions separately and together. This was similar to the findings of Lustosa et al (19) , who also studied p53 and bcl-2 separately and together.…”
Section: Discussionsupporting
confidence: 92%
“…On the other hand, bcl-2 has been correlated with recurrence by some authors, although other studies have shown the same result as in the present study (19,20) . With regard to Ki-67, this study showed a statistically significant correlation between immunohistochemical expression of this protein and recurrence (P = 0.035).…”
Section: Discussionsupporting
confidence: 85%
“…The evaluation of cell cycle-related proteins in neoplasms by immunohistochemistry has been included in prognostic staging in central nervous system 25,26 and other tumors 21,[27][28][29][30] . We verified if these same proteins could also play a prognostic role in GIST 20,31 .…”
Section: Discussionmentioning
confidence: 99%
“…Classically, chemotherapy agents hit cells in an apoptosis pathway. In carcinomas and lymphomas, a higher contingent of apoptotic cells may represent a better response to chemotherapy 30,32 . Unlike many chemotherapeutic agents, imatinib mesylate, used in GIST is not based on a proliferating contingent of cells, but rather a blocking tyrosine kinase receptors and the further induction of cellular proliferation 33 .…”
Section: Discussionmentioning
confidence: 99%
“…Samples were considered positive for p53 when at least 10% of the cells presented this staining (10,17) . The cell proliferation index for Ki-67 (i.Ki-67) was calculated with the same formula and was expressed in absolute values.…”
Section: Quantitative Analysis Of P53 and Ki-67mentioning
confidence: 99%