Estudo comparativo da hiperoxigenação hiperbárica em alças cólicas isquêmicas em ratos

Rocha, Antonio Angelo; Coy, Cláudio Sadi Rodrigues; Góes, Juvenal Ricardo Navarro; Ayrizono, Maria de Lourdes Setsuko; Wu, Feng; Fagundes, João José

doi:10.1590/s0102-86502005000200009

Cited by 1 publication

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References 19 publications

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“…Diminished blood flow in the surgical incision leads to dehiscence. In this scenario, the correct hypoxemia level secured by the use of hyperbaric oxygen could be seen as an efficient, complementary treatment strategy 12 . The literature lists several publications on the negative effects of poorly oxygenated tissue on healing 4,13 .…”

Section: Discussionmentioning

confidence: 99%

“…This may be explained by potentially higher mortality rates due to complications, and by the fact that rodents suffer from early-stage dysfunctions such as the stenosis of anastomosis and other conditions that may become visible later, like malnutrition 23 . Several authors investigated HBO efficiency against ischemic intestinal segments without anastomosis, and reached controversial conclusions as to the benefits the method offers 12,[24][25] . Hamzaoglu et al 9 assessed the effects of HBO on anastomotic sites in the large intestine of rats.…”

Section: Discussionmentioning

confidence: 99%

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Effect of hyperbaric oxygen therapy on esophagojejunal anastomosis healing in rats

Lionço¹,

Lionço²,

Filippi³

et al. 2008

Acta Cir. Bras.

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Purpose: To evaluate hyperbaric oxygen therapy (HBO) after esophagojejunal anastomosis in a rat experimental model and the effect of HBO on the healing of esophagojejunal anastomosis in gastrectomized rats. Methods: Forty adult male Wistar rats, weighing 322 g to 506 g, were divided into two random groups. In group A (control group), 20 rats were subjected to total gastrectomy. In group B, 20 rats were similarly gastrectomized, but also received postoperative HBO treatment for 90 minutes/day for seven days. All rats were sacrificed on the eighth postoperative day and evaluated according to the following study variables: a) presence of anastomotic fistula; b) evaluation of esophagojejunal anastomosis healing by measuring the breaking strength at the suture line as per Hendriks & Mastboom; and c) determining the collagen concentration in the anastomosis, as per Kovács criteria. For the comparative statistical analysis between groups, Student's "t" test was used. A value of p<0.05 was considered significant. Results: There was a 20% mortality rate. There were five deaths in group A and three in group B (p=N.S.). There was only one anastomotic fistula in each group, and neither caused any morbidity or death. Breaking strength measured at the suture line (p=0.528) and collagen concentration determined at the esophagojejunal anastomosis (p=0.89) were not significantly different between Groups A and B. Conclusion: Hyperbaric oxygen therapy did not affect the healing process of esophagojejunal anastomosis. Key words: Anastomosis, Surgical. Collagen. Tensile Strength. Oxygen Inhalation Therapy. Rats. RESUMO Objetivo:Avaliar o efeito da oxigenoterapia hiperbárica na cicatrização da anastomose esôfagojejunal em ratos gastrectomizados. Métodos: 40 ratos Wistar, adultos machos, pesando entre 322g e 506g, foram divididos aleatoriamente em dois grupos. No grupo A (grupo controle) 20 ratos foram submetidos à gastrectomia total. No grupo B, 20 ratos foram gastrectomizados e receberam tratamento pós-operatório com oxigênio hiperbárico, 90 minutos/dia durante sete dias. Todos os ratos foram sacrificados no oitavo dia pós-operatório e avaliados de acordo com as seguintes variáveis: a) presença de fístula anastomótica; b) avaliação da cicatrização da anastomose esôfagojejunal pela medida da força de ruptura à tração na linha da sutura conforme Hendriks & Mastboom; c) determinação da concentração de colágeno na anastomose pelos critérios de Kovács. Para análise estatística comparativa entre os grupos foi utilizado o teste "t" de Student, considerando-se como significativo o valor de p=0.05. Resultados: A mortalidade foi de 20%. Morreram cinco ratos do grupo A e tres do grupo B (p= N.S.). Ocorreu uma fístula anastomótica em cada grupo não relacionadas a óbito. A medida da força de ruptura à tração na linha da sutura (p= 0.528) e a determinação da concentração de colágeno na anastomose esôfagojejunal (p= 0.89) não mostrou diferença estatisticamente significativa entre os grupos A e B. Conclusão: A oxigenoterapia hiperbárica não...

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect of hyperbaric oxygen therapy on esophagojejunal anastomosis healing in rats

Lionço¹,

Lionço²,

Filippi³

et al. 2008

Acta Cir. Bras.

View full text Add to dashboard Cite

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Estudo comparativo da hiperoxigenação hiperbárica em alças cólicas isquêmicas em ratos

Abstract: The hyperbaric oxygen-therapy did not present improvement on the induced ischemia in rats upright colic loop.

Cited by 1 publication

References 19 publications

Effect of hyperbaric oxygen therapy on esophagojejunal anastomosis healing in rats

Effect of hyperbaric oxygen therapy on esophagojejunal anastomosis healing in rats

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