Efeitos do Tenoxicam sobre a cicatrização da parede abdominal: estudo experimental em ratos

Watanabe, André Luís Conde; Watanabe, Luís Massaro

doi:10.1590/s0102-86502005000200007

Cited by 7 publications

(11 citation statements)

References 18 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absence of dehiscence, fistulas or infections in all animals studied demonstrates that copaiba oil did not interfere in the process of healing of abdominal wall with enough intensity to cause early clinical changes as occurred in studies using tenoxicam 13 and meloxican 18 . Macroscopic results were similar to those found by Pundek et al 19 studying polypropylene/ polyglecaprone meshes.…”

Section: Discussionmentioning

confidence: 71%

“…Some anti-inflammatory drugs have already been tested in the healing of rats' abdominal walls, and the results remain controversial, depending on the drug group studied 12,13,18 .…”

Section: Discussionmentioning

confidence: 99%

“…The postoperative pain control is of great importance for hernia surgery, since the use of anti-inflammatory drugs may reduce healing responses 12,13 . Copaiba oil -a medicinal plant of the Amazon region, Brazil-stands today at the level of the public policies of the World Health Organization to encourage the use of medicinal plants; since copaiba oil has proven to have antiinflammatory and healing effects 15,16 .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh

Yasojima¹,

Teixeira²,

Houat³

et al. 2013

Acta Cir. Bras.

View full text Add to dashboard Cite

PURPOSE:To evaluate the effects of copaiba oil on the correction of abdominal defect treated with the use of polypropylene/ polyglecaprone mesh in rats. METHODS:A defect in the abdominal wall was created and corrected with polypropylene/polyglecaprone mesh in 36 rats. They were randomly distributed into three groups: control, copaiba by oral administration (gavage) and copaiba oil dip in the mesh. Euthanasia was performed after seven, 14 and 21 post-operative days. The healing process was analyzed regarding the meshes and macroscopic and microscopic aspects. RESULTS:All animals had abdominal adhesions, which were smaller in the copaiba (gavage) group (p<0.05). In microscopy, all animals had an acute inflammation stage and the inflammatory response was best characterized by foreign body-type granulomas around the mesh fragments, which was not found in the mesh fragments within the copaiba dip group. There was a greater area of necrosis and fibrosis in the copaiba dip group compared to the control group (p<0.05). The copaiba (gavage) group had a greater quantity of collagen fibers compared to the control group. CONCLUSION:Copaiba oil administered by gavage decreased the amount of abdominal adhesions, besides accelerating the process of collagen fibers formation, without damages within the early stages of healing. However, when used by dip directly on the mesh, it had corrosive effects compromising the healing process of the abdominal wall.

show abstract

Section: Discussionmentioning

confidence: 71%

“…Some anti-inflammatory drugs have already been tested in the healing of rats' abdominal walls, and the results remain controversial, depending on the drug group studied 12,13,18 .…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh

Yasojima¹,

Teixeira²,

Houat³

et al. 2013

Acta Cir. Bras.

View full text Add to dashboard Cite

show abstract

“…Breaking strength assessment, despite exposing the scar to extremely adverse situations that are hardly encountered after operation, has been frequently used to determine surgical wound tissue cohesion at different healing stages 13,14 . In this study, no significant statistical difference in this variable was observed between groups at all time points.…”

Section: Discussionmentioning

confidence: 99%

Comparative study between two techniques of incisional hernia repair with polypropylene mesh in rabbits

et al. 2010

View full text Add to dashboard Cite

Purpose:To compare two different incisional hernia repair techniques (repair with a polypropylene mesh reinforcement on the peritonium-aponeurosis versus polypropylene mesh sutured to the borders of the hernial ring as a bridge) in rabbits. Methods: Incisional hernia was experimentally developed through a 4-cm median incision in 60 rabbits. After 30 days, half of the animals were operated for primary wall closure and placement of a polypropylene mesh reinforcement, while the other half had a polypropylene mesh sutured to the borders of the hernial ring as a bridge. Clinical development, scar breaking strength, as well as gross, microscopic and morphometric parameters were evaluated in all animals 30, 60, and 90 days after repair. Results: No significant differences in breaking strength or histological parameters were observed between groups at any time point studied. No statistical difference regarding complications was detected, although denser and firmer adhesions to the abdominal wall were seen after the mesh was placed as a "bridge". Conclusions: No significant differences between the incisional hernia repair techniques assessed were observed regarding breaking strength, and histological and morphometric parameters. The number of complications was similar in both study groups. However, adhesion of abdominal cavity organs to the scar area was much denser after the placement of a mesh to bridge the defect. Key words: Hernia, Ventral. Polypropylenes. Surgical Mesh. Rabbits. RESUMOObjetivo: Comparar duas técnicas de tratamento da hérnia incisional em coelhos utilizando a tela de polipropileno apoiando um reforço peritônio -aponeurótico ou suturada nas bordas do anel herniário 'em ponte". Métodos: Foram operados 60 coelhos para a produção de hérnia incisional, em uma incisão mediana de 4 centímetros. Após 30 dias, metade dos animais foram operados com o fechamento primário da parede, com colocação de uma tela de polipropileno apoiando o reforço e a outra metade dos animais com a colocação da tela suturada nas bordas do anel herniário "em ponte". Os animais foram avaliados com 30 (M1), 60 (M2)e 90 (M3) dias de pós-operatório. Os parâmetros analisados foram a evolução clínica, análise da força de ruptura da cicatriz, estudo macroscópico, análise microscópica e morfométrica. Resultados: Não foram observadas diferenças significantes com relação a força de ruptura e estudos histológicos nos dois grupos e vários momentos estudados. Não houve diferença estatística com relação às complicações, embora os animais que receberam a tela "em ponte" tiveram aderências mais firmes e intensas à parede abdominal. Conclusões: As duas técnicas utilizadas para correção da hérnia incisional em coelhos não mostraram diferenças significantes quanto a força de ruptura, análise histológica e morfométrica. O número de complicações foi semelhante, porém a aderência de órgãos da cavidade abdominal à área de cicatriz foi muito mais intensa no grupo em que a tela foi colocada "em ponte". Descritores: Hérnia Ventral. Polipropilenos.Tel...

show abstract

“…The rats receive the standard diet with water ad libitum [10][11][12] . All the rats passed by the same operatory procedure.…”

Section: Methodsmentioning

confidence: 99%

Effects of bromopride on abdominal wall healing with induced peritoneal sepsis after segmental colectomy and colonic anastomosis in rats

et al. 2011

View full text Add to dashboard Cite

Effects of bromopride on abdominal wall healing with induced peritonealsepsis after segmental colectomy and colonic anastomosis in rats IEfeitos da bromoprida na cicatrização da parede abdominal com sepse peritonial induzida e submetidos à ressecção segmentar e anastomose do cólon esquerdo em ratos ABSTRACT PURPOSE: Evaluate the effects of bromopride on abdominal wall healing of rats with induced peritoneal sepsis after segmental colectomy and colonic anastomosis. METHODS:Forty rats underwent sectioning of the left colon and end-to-end anastomosis and were divided into two groups of 20 animals for the administration of bromopride (bromopride group -B) or saline solution (control group -C). Each group was divided into subgroups of 10 animals each to be killed on the third (GB3 and GC3) or seventh postoperative day (GB7 and GC7). It was analyzed the following characteristics: breaking strength of the abdominal wall's wound; surgical and histopathological features of the abdominal wall; and clinical features of the rats. RESULTS:There was no difference between the groups in relation to the weight of the rats and the breaking strength of the abdominal wall's wound. The GB7 group presented less edema and less quantity of fibrin during histopathological evaluation compared to the GC7 group. CONCLUSION: Bromopride did not have harmful effects on the healing of abdominal wall in rats.Keywords: Wound Healing. Abdominal Wall. Dopamine Antagonists. Antiemetics. Rats. RESUMO OBJETIVO:Avaliar o efeito da bromoprida, na cicatrização da ferida operatória da parede abdominal de ratos com sepse peritoneal experimentalmente induzida e submetidos a ressecção segmentar e anastomose de cólon esquerdo.MÉTODOS: 40 ratos distribuídos em dois grupos contendo 20 animais, para administração de bromoprida (grupo bromoprida-B) ou solução de NaCl 0,9% (grupo controle -C). Cada grupo foi dividido em subgrupos contendo 10 animais, para eutanásia no terceiro (GB3 e GC3) ou sétimo dia (GB7 e GE7) de pós-operatório. Os ratos foram submetidos à secção do cólon esquerdo e anastomose término-terminal. No dia da eutanásia foram avaliadas as características cirúrgicas da cavidade abdominal e clínicas dos ratos. Foram coletados segmentos da parede para a avaliação histopatológica e de resistência tênsil da ferida operatória. RESULTADOS:Não houve diferenças entre os pesos dos ratos e resistência tênsil da ferida operatória nos dois grupos. Em relação a análise histopatológica, o grupo GB7 apresentou menos edema e menos fibrina que o grupo GC7. Não houve outras diferenças. CONCLUSÃO:A utilização de bromoprida não resultou em distúrbios ou retardo da cicatrização no grupo de ratos submetidos à laparotomia e anastomose término-terminal em condições de sepse peritoneal.Descritores: Cicatrização. Parede Abdominal. Antagonistas de Dopamina. Antieméticos. Ratos.Oliveira MVM et al.

show abstract

Efeitos do Tenoxicam sobre a cicatrização da parede abdominal: estudo experimental em ratos

Cited by 7 publications

References 18 publications

Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh

Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh

Comparative study between two techniques of incisional hernia repair with polypropylene mesh in rabbits

Effects of bromopride on abdominal wall healing with induced peritoneal sepsis after segmental colectomy and colonic anastomosis in rats

Contact Info

Product

Resources

About