Efeito do óleo de copaíba nas aminotransferases de ratos submetidos à isquemia e reperfusão hepática com e sem pré-condicionamento isquêmico

Júnior, Francisco Alves de Araújo; Braz, Marcelle Nobre; Neto, Ozéas Galeno da Rocha; Costa, Felipe D’Almeida; Brito, Marcus Vinicius Henriques

doi:10.1590/s0102-86502005000100013

Cited by 21 publications

(10 citation statements)

References 16 publications

(25 reference statements)

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“…In liver lesions and transplants, temporary blockage of hepatic blood flow is sometimes necessary to facilitate surgical maneuvers [1,2]. Since 1908, Pringle proposed full clamping of the hepatic pedicle (hepatic artery, portal vein, and the common bile duct) to restrain hepatic hemorrhages [3].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of potential changes in liver and lung tissue of rats in an ischemia-reperfusion injury model (modified pringle maneuver)

et al. 2017

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In surgical procedures involving the liver, such as transplantation, resection, and trauma, a temporary occlusion of hepatic vessels may be required. This study was designed to analyze the lesions promoted by ischemia and reperfusion injury of the hepatic pedicle, in the liver and lung, using histopathological and immunohistochemical techniques. In total, 39 Wistar rats were divided into four groups: control group (C n = 3) and ischemia groups subjected to 10, 20, and 30 minutes of hepatic pedicle clamping (I10, n = 12; I20, n = 12; I30, n = 12). Each ischemia group was subdivided into four subgroups of reperfusion (R15, n = 3; R30, n = 3; R60, n = 3; R120, n = 3), after 15, 30, 60, and 120 minutes of reperfusion, respectively. Significant differences were observed in the liver parenchyma (P < 0.05) between the values of microvesicles and hydropic degeneration at different times of ischemia and reperfusion. However, the values of vascular congestion, necrosis, and pyknotic nuclei showed no significant differences (P > 0.05). In the lung parenchyma, a significant difference was observed (P < 0.05) between the values of alveolar septal wall thickening and inflammatory infiltration at different times of ischemia and reperfusion. However, there was no significant difference (P < 0.05) between the values of vascular congestion, bronchial epithelial degeneration, interstitial edema, and hemorrhage. The positive immunoreactivity of caspase-3 protein in the liver parenchyma (indication of ongoing apoptosis), showed no significant differences (P > 0.05) at different times of ischemia and reperfusion. In the pulmonary parenchyma, the immunoreactivity was not specific, and was not quantified. This study demonstrated that the longer the duration of ischemia and reperfusion, the greater are the morphological lesions found in the hepatic and pulmonary parenchyma.

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Section: Introductionmentioning

confidence: 99%

Evaluation of potential changes in liver and lung tissue of rats in an ischemia-reperfusion injury model (modified pringle maneuver)

et al. 2017

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“…Cesalpinoídea (CASCON, 2004;BRITO et al 2005;VEIGA JUNIOR et al 2005;OLIVEIRA et al 2006; VEIGA JUNIOR e PINTO, 2002;ARAÚJO JÚNIOR et al 2005;OLIVEIRA et al 2006;RAMOS, 2006;TOGASHI et al 2008) (PACHECO et al 2006;PACKER e LUZ, 2007;SANTOS et al 2008;MENDONÇA e ONOFRE, 2009;.…”

Section: Resultsmentioning

confidence: 99%

AVALIAÇÃO IN VITRO DE ÓLEOS ESSENCIAIS DE COPAÍBA, BURITI E TUCUMÃ PARA CONTROLAR Sthapylococcus aureus

Bertipaglia¹,

Rezende²,

Melo³

et al. 2020

Produção E Controle De Produtos Naturais 2

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Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição 4.0 Internacional (CC BY 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.

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“…This finding supports the hypothesis that the model used here induced initial liver injuries, although we were not able to demonstrate cell lysis or cholestasis, conditions directly associated with high serum levels of transaminases [ 49 ]. The tissue lesions that occur in advanced stages of NAFLD, such as steatohepatitis, liver fibrosis, and cirrhosis, are aggressive hepatic lesions which involve massive hepatocyte necrosis and increased circulating levels of aminotransferases [ 50 ]. Even in the initial phase of liver disease, the hepatoprotective effect of baru oil was a remarkable finding, particularly considering that nontreated conditions (i.e., dyslipidaemia) can develop into NAFLD, liver failure, and death [ 51 , 52 ].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds (Dipteryx alata Vog.) in a Preclinical Model of Lipotoxicity and Dyslipidemia

Reis

Novaes

Baggio

et al. 2018

Evidence-Based Complementary and Alternative Medicine

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The oil obtained from baru (Dipteryx alata Vog.) almonds exhibits high energy value and is reported in popular medicine for the treatment of rheumatic diseases and reproductive disturbances. Although baru oil is used in domestic cuisine, the chemical characterization of this oil and its effects on lipid metabolism are still poorly understood. Therefore, this study evaluated the fatty acid (FA) profile and the effects of baru oil on liver and aorta in a murine model of dyslipidemia. The chromatographic profile of baru oil showed high levels of unsaturated FAs, especially oleic acid. Saturated FAs, such as palmitic and lignoceric acids, were found in lower amounts. Hypercholesterolemia was induced in male Wistar rats by daily administration of a lipid emulsion by gavage for 15 weeks. Biochemical and histopathological analysis were performed on serum, aorta, and liver. The results demonstrated that animals developed marked hypercholesterolemia, liver steatosis, and increased lipid peroxidation in the aorta. Treatment with baru oil attenuated lipid peroxidation and drastically reduced liver damage, especially ballooning degeneration and steatosis. By restricting vascular and hepatic injury, this oil showed potential applicability as a functional food, reinforcing its use in popular medicine and domestic cuisine.

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Efeito do óleo de copaíba nas aminotransferases de ratos submetidos à isquemia e reperfusão hepática com e sem pré-condicionamento isquêmico

Cited by 21 publications

References 16 publications

Evaluation of potential changes in liver and lung tissue of rats in an ischemia-reperfusion injury model (modified pringle maneuver)

Evaluation of potential changes in liver and lung tissue of rats in an ischemia-reperfusion injury model (modified pringle maneuver)

AVALIAÇÃO IN VITRO DE ÓLEOS ESSENCIAIS DE COPAÍBA, BURITI E TUCUMÃ PARA CONTROLAR Sthapylococcus aureus

Hepatoprotective and Antioxidant Activities of Oil from Baru Almonds (Dipteryx alata Vog.) in a Preclinical Model of Lipotoxicity and Dyslipidemia

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