Estudo comparativo entre cinco diferentes tratamentos sobre as alterações clínicas e laboratoriais do rato diabético induzido pela aloxana

Spadella, César Tadeu; Macedo, Célia Sperandeo; Machado, José Lúcio Martins; Schellini, Silvana Artioli; Padovanni, Carlos Roberto

doi:10.1590/s0102-86502005000100008

Cited by 4 publications

(3 citation statements)

References 27 publications

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“…The persistance of hyperglycemia, during the insulin treatment, observed in the present study, was also described in recent researches (Delfino et al 2002, Spadella et al 2005.…”

Section: Discussionsupporting

confidence: 91%

Role of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice

et al. 2016

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RESUMO.-[Papel das células-tronco mesenquimais autólogas em comparação com plasma rico em plaquetas na cicatrização de feridas cutâneas em camundongos diabéticos.] Lesões cutâneas crônicas afetam 15% dos pacientes diabéticos e humanos representam um risco 15 a 46 vezes maior de amputações de membros em comparação com as pessoas com a glicemia normal. Supõe-se que a metade destas amputações poderia ser evitada por meio do tratamento precoce das feridas cutâneas com, por exemplo, uma adequada terapia celular. Objetivos: Neste estudo, a ação do transplante autólogo de células estaminais mesenquimais (MSC) foi avaliada em comparação com o tratamento com plasma rico em plaquetas autólogo (PRP) na cicatrização de lesões cutâneas induzidas em camundongos diabéticos. Estes animais foram previamente tratados com estreptozotocina para induzir diabetes mellitus e feridas redondas de 1,5 cm de diâmetro foram criadas na região posterior. Os diâmetros dos ferimentos e tempo de cicatrização foram avaliados durante 30 dias e os resultados fo- (7):617-624. Departamento de Clínica e Cirurgia Veterinária, Universidade Federal do Piauí, Campus Socopo, Teresina, PI 64049-550, Brazil. E-mail: argolo_napoleao@ufpi.edu.br Chronic cutaneous lesions affect 15% of diabetic human patients and represent a risk 15 to 46 times larger of limb amputations compared to people with normal glycemia. It is assumed that half of these amputations could be prevented by early treatment of wounds, for example, with proper cell therapy. Objectives: In this study, the action of the autologous transplant of mesenchymal stem-cells (MSC) was evaluated compared to the treatment with autologous platelet rich plasma (PRP) in the cicatrization of cutaneous lesions induced in diabetic mice. These animals were previously treated with streptozootocin to induce diabetes mellitus and round wounds of 1.5cm in diameter were created in the posterior region. Diameters of the wounds and healing time were evaluated during 30 days and the results were submitted to variance analysis and Tukey's test average. It was noticed that the animals treated with MSC presented a more accelerated cicatrization of the cutaneous lesion than the animals treated with PRP. However, the treatment with PRP presented better results than just the daily asepsis of the lesions with saline or covering them with semi-permeable bandage. Besides, the use of semi-permeable bandage kept the cutaneous lesions of diabetic mice did not interfere negatively with cicatrization, proved to be harmless to use, but kept the cutaneous lesions more hydrated than the ones exposed to the environment.

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“…The persistance of hyperglycemia, during the insulin treatment, observed in the present study, was also described in recent researches (Delfino et al 2002, Spadella et al 2005.…”

Section: Discussionsupporting

confidence: 91%

Role of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice

et al. 2016

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“…Diabetes Mellitus is currently considered a public health issue worldwide, both in terms of the number of people affected and in relation to the costs involved in controlling and treating its complications (Spadella et al 2005). The patients with diabetes mellitus are characterized by presenting a relative, or absolute deficiency of insulin, hyperglycemia, glycosuria, tendency to develop atherosclerosis, microangiopathy, nephropathy and neuropathy.…”

Section: Introductionmentioning

confidence: 99%

Healing effect of the ointment made of Equisetum pyramidale in the treatment of cutaneous lesions in diabetic rats

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Dourado

et al. 2013

Braz. arch. biol. technol.

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“…A indução do diabetes poder ser realizada por diversos mecanismos, tais como, indução por estresse, infecções, hormônios anti-insulinicos e manipulação como a pancreactomia (MORDES e ROSSINI, 1985). Esta indução também pode ser realizada experimentalmente também por meio de drogas diabetogênicas como aloxana e estreptozotocina (SPADELLA et al, 2005;LERCO et al, 2003).…”

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Efeito terapêutico do chá verde na morfologia das glândulas submandibulares de ratos com diabetes induzido pela estreptozotocina

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Estudo comparativo entre cinco diferentes tratamentos sobre as alterações clínicas e laboratoriais do rato diabético induzido pela aloxana

Abstract: Conventional treatments with insulin, acarbose, and insulin plus acarbose improved the severe diabetic state of the alloxan-diabetic rats, but pancreas and islet transplantation have a better performance for treatment of diabetes.

Cited by 4 publications

References 27 publications

Role of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice

Role of the autologous mesenchymal stem cells compared with platelet rich plasma on cicatrization of cutaneous wounds in diabetic mice

Healing effect of the ointment made of Equisetum pyramidale in the treatment of cutaneous lesions in diabetic rats

Efeito terapêutico do chá verde na morfologia das glândulas submandibulares de ratos com diabetes induzido pela estreptozotocina

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