Investigating the relationship between hemodynamic and metabolic parameters in portal triade occlusion following hemorrhagic shock

Fontelles, Mauro José; Mantovani, Mário; Hirano, Élcio Shiyoiti; Morandin, Rosana Celestina

doi:10.1590/s0102-86502005000100005

Cited by 2 publications

(1 citation statement)

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“…6 In humans, 30 minutes of PTO has been accepted as a safe procedure, and is usually employed in liver surgery. 7 More recently, Fontelles et al 8 demonstrated a clear correlation among hemodynamic and metabolic variables in rats subjected to hemorrhagic shock followed by 15 minutes of PTO; although not focused on mortality, the study points out the continued relevance of PTO in the surgery of trauma. On the other hand, selective portal vein occlusion (SPVO) may be achieved by means or ligation of the vein 1 .…”

Section: Introductionmentioning

confidence: 94%

Evaluation of the mortality rate caused by different periods of selective portal vein occlusion in rats

Kato¹,

Poggetti²,

Fontes³

et al. 2007

Acta Cir. Bras.

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Evaluation of the mortality rate caused by different periods of selective portal vein occlusion in rats ABSTRACTMortality from acute selective portal vein occlusion (SPVO) is a matter of concern for surgeons during the management of traumatic portal vein injury. However, mortality rates related to different periods of SPVO remains undetermined. Purpose: To determine the mortality rates resulting from different periods of acute SPVO in rats. Methods: Wistar male rats were randomized into 8 experimental, and 8 control groups. Experimental animals underwent SPVO during 15 to 75 minutes, and control groups underwent sham procedures. All surviving animals were followed up to 14 days for assessment of mortality rate. Results: Death rates varied from 0% in the 15 min SPVO group, to 100% with 65 and 75 minutes of SPVO. A strongly positive correlation was observed between mortality rates and SPVO periods (p<0.001) with either linear or quadratic regression analysis tests. All deaths in the 20min and 25min SPVO groups occurred after 75 min from the moment of clamping (or after 60 min from unclamping); death from 30 or more min SPVO occurred predominantly within 75 min from clamping moment (or within 60 min from unclamping). (Exact Fisher test, p=0.009). Conclusions:The mortality from SPVO in rats increases with longer duration of SPVO; with deaths occurring later for short periods (≤ 25 min) of SPVO and earlier for longer periods (≥ 30 min) of SPVO. Key words: Portal Vein. Constriction. Mortality. Rats. RESUMOA mortalidade da oclusão seletiva da veia porta (OSVP) preocupa os cirurgiões durante o tratamento de lesão traumática da veia porta. Entretanto, as taxas de mortalidade decorrentes de diferentes períodos de OSVP não estão determinadas. Objetivo: Determinar a mortalidade Decorrente de diferentes períodos de oclusão seletiva da veia porta (OSVP) em ratos. Métodos: Ratos Wistar machos foram randomizados em 8 grupos experimentais e 8 controles. Os experimentais foram submetidos a OSVP por períodos de 15 a 75 minutos, seguidos de observação até o óbito, e os sobreviventes até 14 dias. Os grupos controles receberam idênticos procedimentos, exceto a OSVP. Resultados: A mortalidade, a partir do momento da oclusão, aumentou progressivamente, de 0% no grupo de 15min, atingindo 100% nos grupos de 65min e 75min de OSVP. Houve alta correlação positiva entre mortalidade e duração da OSVP (p<0.001; tanto em teste de Regressão linear quanto quadrática). Os óbitos decorrentes de 20 e 25 min de OSVP ocorreram após 75min do clampeamento (ou após 60 min do desclampeamento); os decorrentes de 30min ou mais ocorreram predominantemente antes de decorridos 75 min do clampeamento (ou 60 min do desclampeamento). (Teste exato de Fisher, p<0.05). Conclusões: A mortalidade da OSVP em ratos aumenta com a maior duração da oclusão; os óbitos ocorrem mais tardiamente após oclusões breves (≤ 25 min), e mais precocemente nas oclusões mais prolongadas (≥ 30 minutos). Descritores: Veia Porta. Constrição. Mortalidade. Ratos. -ORIGINAL ARTICLE

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Section: Introductionmentioning

confidence: 94%