Prevalence and bacterial susceptibility of hospital acquired urinary tract infection

Neto, José Anastácio Dias; Silva, Leonardo Dias Magalhães da; Martins, Antônio Carlos Pereira; Tiraboschi, Ricardo Brianezi; Domingos, André Luis Alonso; Suaid, Haylton Jorge; Tucci, Sílvio; Cologna, Adauto José

doi:10.1590/s0102-86502003001200013

Cited by 22 publications

(8 citation statements)

References 10 publications

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“…29 In this study, E. coli was the most common organism isolated in the culture of the urine sample (68.5%) followed by klebsiella (18.4%), which is in congruence with other studies. 13,[30][31][32][33] This study also showed a lower prevalence of Gram-positive pathogens (0.4%). Contrary to our findings, few other studies have demonstrated a higher proportion of these pathogens ranging up to 26%.…”

Section: Discussionsupporting

confidence: 54%

Antibiotic sensitivity pattern in urinary tract infection among adults in central part of Nepal

Sedhain

Sapkota²,

Shrestha³

2019

J Chitwan Med Coll

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Background: Urinary tract infection (UTI) is characterized by pathological invasion of the urinary tract by microorganisms. Majorities of organisms causing UTI are gram negative bacteria, most common of which is E. coli. Urine culture and sensitivity test is used to isolate the organism and to identify the susceptible drug of choice for appropriate treatment. This hospital-based study was carried out to analyze the spectrum and antibiotic susceptibility of microorganisms causing UTI. Methods: A retrospective study was done to analyze the results of urine culture and sensitivity test done at Chitwan Medical College Teaching Hospital over a period of two and half years. Standard guideline and protocol were used to collect the urine sample and to perform the test. Data analysis was done using SPSS version 21.0. Result: Out of 12, 925 urine samples submitted for culture and sensitivity test during the study period, bacterial pathogens were isolated from 3, 173 (24.54%) samples, which was significantly higher among females (28%) than the males (17%). The most common organism isolated on the culture was E. coli (68.5%) followed by Klebsiella (18.4%). Sensitivity of the uropathogens was seen highest with colistin (79.2%) followed by teicoplanin (64.58%), Aztreonam (63.25%) and Nitrofurantoin (61.16%). Most common antibiotics that showed resistance to the microorganisms in this study were Ampicillin (60.93%), Cotrimoxazole (53.72%), Cefixime (40.57%) and Levofloxacin (32.93%). Conclusions: This study has found a usual pattern of UTI with higher prevalence among females and E. coli being the most common organism. Nitrofurantoin has been found to have a good susceptibility for the treatment of UTI.

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Section: Discussionsupporting

confidence: 54%

Antibiotic sensitivity pattern in urinary tract infection among adults in central part of Nepal

Sedhain

Sapkota²,

Shrestha³

2019

J Chitwan Med Coll

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“…Since treatment of UTI is frequently started empirically, prior information on the prevalence of causative agents as well as the antimicrobial susceptibility profiles in a particular setting is essential [ 20 ]. However, the distribution of UTI causative agents and their antibiotic susceptibility profiles differs regionally [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Multidrug Resistance and Extended-Spectrum β-Lactamase Carriage of Clinical Uropathogenic Escherichia coli Isolates in Riyadh, Saudi Arabia

Alqasim

Jaffal

Alyousef

2018

International Journal of Microbiology

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The prevalence of extended-spectrum β-lactamase-producing Escherichia coli (ESBL-producing E. coli) has recently increased worldwide. This study aims at determining the antimicrobial susceptibility patterns of a collection of clinical E. coli urine isolates and evaluating the ESBL carriage of these isolates at phenotypic and genotypic levels. A total of 100 E. coli urine isolates were collected at a tertiary healthcare centre in Riyadh from January 2018 to March 2018. Antimicrobial susceptibility testing was carried out for all isolates. ESBL production was characterized at phenotypic and genotypic levels using double-disc synergy test and polymerase chain reaction, respectively. Detection of different ESBL variants was performed using DNA sequencing. Of 100 E. coli isolates, 67 were associated with multidrug resistance (MDR) phenotype. All isolates showed variable resistance levels to all antibiotics used here expect to imipenem, where they were all imipenem-sensitive. 33 out of 100 E. coli isolates were positive for ESBLs by phenotypic and genotypic methods. Among all ESBL-positive E. coli isolates, the CTX-M was the most prevalent ESBL type (31/33 isolates; 93.94%). CTX-M-15 variant was detected in all isolates associated with CTX-M carriage. Multiple ESBL gene carriage was detected in 15/33 isolates (45.45%), where 11 (33.33%) isolates produced two different ESBL types while 4 isolates (12.12%) associated with carrying three different ESBL types. Our study documented the high antimicrobial resistance of ESBL-producing E. coli to many front-line antibiotics currently used to treat UTI patients, and this implies the need to continuously revise the local guidelines used for optimal empirical therapy for UTI patients. It also showed the high prevalence of ESBL carriage in E. coli urine isolates, with CTX-M-15 being the most predominant CTX-M variant.

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“…The antibiotic sensitivity patterns of bacteria isolated from urinary tracts differ for different bacteria and antibiotics [ 6 , 7 , 13 ] with sensitivity to the Quinolones being usual while resistance is often seen to nitrofurantoin; Ampicillin and Cotrimoxazole. So far, E.coli has been reported as the most resistant microorganism almost for all antibiotics including Quinolones [ 6 , 14 ] leading to recurrent infections [ 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Prevalence and antibiotic resistance pattern of urinary tract bacterial infections in Dessie area, North-East Ethiopia

Abejew¹,

Denboba

Mekonnen³

2014

BMC Res Notes

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BackgroundDifferent studies have indicated that urinary tract infections frequently occur in both community and hospital environments and are of the most common bacterial infections in humans. the outcomes of urinary tract infections are increased hospitalization, increased direct patient costs and mortality. In Dessie, the prevalence of the commmon pathogens and antibiotic susceptibility pattern is not well studied sofar. Thus, the aim of this study is to address these gaps in the study area.MethodsRetrospective study was conducted in Dessie regional health reseacrh laboratory from January 1-March 31, 2012. All culture and antibiotic susceptibility test results of patients’ diagnosed with UTI from September 2002 to September 2011 G.C were included in the study. Data were abstracted using structured questionnaires and finally, entered into SPSS Windows version 16.0, and descriptive statistics was generated to meet the study objective.ResultsDuring the last ten years 680 (27.35%) bacteria were isolated in the regional laboratory. The most commonly isolated were E. coli 410 (60.29%), Pseudomonas species 59 (8.68%), Proteus species 53 (7.79%), S. aurous 50 (7.35%) and Klebsiella species 40 (5.88%). The E.coli were susceptible to Nitrofurantoin 43 (89.6%), furantoin 124 (87.3%), Nalidixic acid 91 (86.7%), kanamycin 116 (80%) & ciprofloxacin 66 (71.7%) but were almost resistant to Ampicillin, tetracycline, & trimethoprim-sulfamethoxazole. Similarly Pseudomonas and proteus species were resistant to almost all antibiotics except Gentamycin.ConclusionThe E.coli, pseudomonas and proteus species were the commonly isolated bacteria in the regional health research laboratory. A majority of isolated bacterial microbes were resistant to antibiotics commonly used in clinical practices and generally available in the local economy without prescription. Culture results are necessary before initiating antibiotics.

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Prevalence and bacterial susceptibility of hospital acquired urinary tract infection

Cited by 22 publications

References 10 publications

Antibiotic sensitivity pattern in urinary tract infection among adults in central part of Nepal

Antibiotic sensitivity pattern in urinary tract infection among adults in central part of Nepal

Prevalence of Multidrug Resistance and Extended-Spectrum β-Lactamase Carriage of Clinical Uropathogenic Escherichia coli Isolates in Riyadh, Saudi Arabia

Prevalence and antibiotic resistance pattern of urinary tract bacterial infections in Dessie area, North-East Ethiopia

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