Utilização de implante ósseo cortical alógeno conservado em glicerina para preservação de membro torácico: estudo experimental em cães

Ziliotto, Liane; Daleck, Carlos Roberto; Filho, J.G. Padilha; Souza, Almir Pereira de; Fantinatti, Alexandra Pinheiro; Diniz, Pedro Paulo Vissotto de Paiva

doi:10.1590/s0102-86502003000200007

Cited by 8 publications

(7 citation statements)

References 10 publications

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“…Glycerin was a good conservation medium for those fragments intended for grafting because, besides being of low cost, it kept bone fragments free of contamination, reducing antigenicity and preserving the functions of osteoinduction and osteoconduction, as described by other authors (Cavassani et al 2001, Ziliotto et al 2003. Furthermore, none of the animals had signs of contamination, infection of the surgical wound or rejection related with the presence of the graft, demonstrated by the complete graft-bone incorporation observed early at 45 days in some animals.…”

Section: Discussionmentioning

confidence: 81%

Using allogeneic cortical graft preserved in glycerin as spacer in the advancement of tibial tuberosity in 34 dogs

et al. 2018

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Cranial cruciate ligament is the main responsible for knee stability by preventing cranial tibial displacement regarding the femur. Deficiency in this ligament (CCLD) may cause subluxation of the tibia and dysfunction of the pelvic member due to overloading. Tibial osteotomies are among the more current surgical techniques for treating CCLD in dogs and they proportionate the dynamic stability by means of modifying bone geometry and the distribution of forces acting on the articulation. The objective of this work is to describe the use of the allogeneic cortical bone graft conserved in glycerin as a spacer on the tibial tuberosity advancement (TTA) for treating the CCLD. In order to do that, 34 dogs submitted to TTA surgery correction were evaluated, being 23 males (67.35%) and 11 females (32.35%). Surgical procedures happened from May 2011 to October 2015. Regarding the surgical procedure after osteotomy of the tibial tuberosity, a disk of allogeneic cortical disk, sawn wedge-hapsed, conserved in glycerin, proportions of 2x1mm was applied as spacer, enabling TTA. Advancements from 3 to 12 mm were executed, depending on the need of the patient. For animals with patella dislocation, trochleoplasty and TTA were executed in order to correct the deviation. The mean ± SD age of animals was 6.67±3.58 and weight was 15.16±12.97 kg. Mongrel dogs, Poodles and Yorkshire terriers were the most affected ones. From the 36 evaluated knees, 11 (30.56%) were associated with some traumatic process and in 25 (69.44%) there was no relation with previous trauma. From those wounds, 20 (55.56%) happened in the right limb and 16 (44.44%) in the left limb and two animals had CCLD bilaterally. Animals had continuous support, discreet drawer movement and negative tibial compression 15 days after surgery. At 30 days, 26 cases (72.22%) had firm support (FS); at 45 days, 24 cases (66 test at 7 and 67%) had FS and eight cases (22.22%) without claudication (WC). During subsequent radiographic evaluations the progressive incorporation of the graft and osteotomy union were observed. In this study, most of the diagnosed CCLD occurred in males diverging from results obtained by other authors that found greater frequency in females. Support without claudication it was observed in most of the cases of implants at 60 days. We concluded that the conserved allogeneic cortical bone graft was able to promote bone union in TTA of dogs with CCLD. None of the animals had signs of contamination, infection of the surgical wound or rejection related with the presence of the graft, demonstrated by the complete graft-bone incorporation observed early at 45 days in some animals. The glycerin was a good conservation medium for those fragments intended for grafting because, besides being of low cost, it kept bone fragments free of contamination, reducing antigenicity and preserving the functions of osteoinduction and osteoconduction. The possibility of molding the graft to the animal need is a characteristic favorable to executing the modified technique that could be molded according to the size of the animal, allowing perfect adaptation to the osteotomized local in different breeds. Intercurrences commonly observed in TTA with patellar dislocation, meniscal lesions, tibial crest fracture and displacement were not found in the animals of this study, probably due to the better distribution of forces between the pass screw in TT and the TTA plate confirming that it has good adaptation to the technique conferring to the modified TTA advantages regarding the conventional TTA.

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Section: Discussionmentioning

confidence: 81%

Using allogeneic cortical graft preserved in glycerin as spacer in the advancement of tibial tuberosity in 34 dogs

et al. 2018

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“…A enzima FA tem grande valor no diagnóstico e prognóstico do osteossarcoma, podendo evidenciar metástases quando se apresenta elevada [29]. Entretanto, cães jovens também apresentam esta enzima elevada devido à formação e crescimento ósseo.…”

Section: Discussionunclassified

“…No Brasil, existe um grande número de proprietários que não autoriza a amputação do membro afetado. Isso impossibilita que o clínico veterinário realize a terapia mais adequada, reduzindo a qualidade de vida e consequente sobrevida do paciente [29].…”

Section: Discussionunclassified

Estudo clínico de osteossarcoma canino

Teixeira

Martins

Fighera

et al. 2018

Acta Scientiae. Vet.

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Background:The canine osteosarcoma is characterized by being an aggressive bone tumor that affects mainly large dogs, middle-aged and male, accounting for 80-85% of bone tumors and 5-6% of all tumors. The risk of developing this tumor is, on average, 125 times greater in dogs weighing over 36 kg than in dogs weighing less than 9 kg. This cancer develops more frequently in the appendicular skeleton (75%), preferably the bones of the forelimbs, where approximately 60% of body weight are sustained. The canine osteosarcoma is very similar to human, in which the metaphyseal region of long bones is the most affected, causing lameness and swelling of the affected limb. The diagnosis is made from epidemiological data, history of the animal, X-rays and laboratory tests such as cytology fine-needle aspiration (FNAC) and measurement of the enzyme alkaline phosphatase (ALP). The staging of the disease becomes a major method for the treatment, whereas primary bone tumors are highly complex and end up interfering with the animal organism in whole. The objective of this study is to report a clinical study of 12 dogs with osteosarcoma, showing the procedures performed from diagnosis to treatment. Material, Methods and Results: Dogs were assisted at the Clinic of Small Animals VUH -UFSM and after the clinical examination were referred to the Department of Radiology. After the radiographic study, blood samples for biochemical and material for cytological analysis of the tumor were collected. After the confirmation of the neoplasm, the physician who prescribed the treatment, depending on the case, the accession to it was left to the owner. In this study, we observed the development of osteosarcoma in dogs from two to 14 years old. Furthermore, in 10 animals (83.3%) the tumor was located in one of the members and nine of these (75%) affected forelimbs. Still, eight dogs (66.7%) were males. The animals weighed on average, 30 kg and five were crossbreeds. Eight dogs (66.7%) had an elevation in enzyme ALP. In this study, five dogs (41%) received no treatment, four (33.3%) were killed and three (25.7%) had the treatment as prescribed by the clinician. Three of the dogs treated survived for a few weeks and two of those who received appropriate treatment survived more than a year. Discussion: The clinical and epidemiological findings of this study corroborate the literature, making them increasingly used in the auxiliary tests cited. For a proper diagnosis it is necessary for the veterinary practitioner to know which tests to determine use. Approximately 98% of the patients have micrometastases at diagnosis, however, only 5% of dogs with osteosarcoma have radiographic evidence of pulmonary metastasis. These will only cause clinical signs in advanced stages, leading the majority of dogs to euthanasia. Moreover, the appearance of bone thinning and explosion in the limb are strong indications of osteosarcoma. The FNAC is one of the main tests for diagnosing neoplastic, because the laboratory technician can visualize the tumor cells in prolif...

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Section: O Introduçãounclassified

Aspectos Clínicos E Fisiopatológicos De Osteossarcoma Em Cães

Gardinalli

Martelli²

2015

SCI. ANIM. HEALTH

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O Osteossarcoma (OSA) é um tumor ósseo maligno caracterizado pela formação de tecido ósseo neoplásico com crescimento rápido e invasivo. Dentre os tumores ósseos primários o OSA é o mais comum devido à proliferação de células mesenquimatosas primitivas e malignas com a produção de matriz osteóide. Sua etiologia permanece desconhecida, porém existem evidências de OSA desenvolverem-se em ossos que sustentam maiores pesos e em sítios adjacentes de fechamento tardio, através da sensibilização celular por fatores mitogênicos, sítios prévios relacionados a implantes ortopédicos metálicos, radiações ionizantes, mutações genéticas e infecções virais. Seu diagnóstico está baseado no histórico clínico do animal, exames físicos, de imagens e histopatológicos. Tratamentos recentes baseiam-se em quimioterapias e cirurgias poupadoras de membros, resultando em um prognóstico mais favorável. O presente trabalho apresenta como objetivo uma revisão da literatura especializada sobre os aspectos clínicos e fisiopatológicos de OSA em cães. Para a composição da revisão foi realizado um levantamento bibliográfico nas bases de dados Scielo, portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), e a busca de dados no Google Acadêmico de artigos científicos nacionais e internacionais e livros acadêmicos. O OSA causa considerável número de mortes, assim um diagnóstico correto e um tratamento apropriado pode melhorar a sobrevida desses animais, levando ao declínio dos índices de mortalidade que vêm sendo observados.

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Utilização de implante ósseo cortical alógeno conservado em glicerina para preservação de membro torácico: estudo experimental em cães

Cited by 8 publications

References 10 publications

Using allogeneic cortical graft preserved in glycerin as spacer in the advancement of tibial tuberosity in 34 dogs

Using allogeneic cortical graft preserved in glycerin as spacer in the advancement of tibial tuberosity in 34 dogs

Estudo clínico de osteossarcoma canino

Aspectos Clínicos E Fisiopatológicos De Osteossarcoma Em Cães

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