2002
DOI: 10.1590/s0102-86502002000700008
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: A esquistossomose mansônica é uma doença tropical que constitui um importante problema de saúde pública, na Região Nordeste do Brasil, onde é encontrada em alta endemicidade. Essa parasitose tem o fígado como principal alvo de suas lesões histológicas, alterações fisiopatológicas e manifestações clínicas. Estudos anteriores reportam alterações no metabolismo lipídico associadas à forma hepatoesplênica da esquistosomose.Uma das principais alterações consiste na redução da atividade da enzima hepática LCAT, resp… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2

Citation Types

0
2
0

Year Published

2004
2004
2018
2018

Publication Types

Select...
3

Relationship

1
2

Authors

Journals

citations
Cited by 3 publications
(2 citation statements)
references
References 10 publications
0
2
0
Order By: Relevance
“…Thus, conjugated dienes are intermediates during MDA production and this could explain the positive and significant correlation between them, both in patients and control groups. However, we recently reported a significant reduction in activity of lecithin-cholesterol acyltransferase, the plasma enzyme which esterifies cholesterol and helps regulate cell membrane lipid composition, in patients with schistosomiasis who had undergone the same clinical and surgical treatments as the patients in the present study (18). This thiol-containing enzyme is highly sensitive to several oxidizing species, either directly or by crosslinking of its co-factor, apoAI (19), and so oxidative stress may contribute to the acquired lecithin-cholesterol acyltransferase deficiency and membrane disturbances (20) seen in human schistosomiasis.…”
Section: Htf Facundo Et Almentioning
confidence: 50%
See 1 more Smart Citation
“…Thus, conjugated dienes are intermediates during MDA production and this could explain the positive and significant correlation between them, both in patients and control groups. However, we recently reported a significant reduction in activity of lecithin-cholesterol acyltransferase, the plasma enzyme which esterifies cholesterol and helps regulate cell membrane lipid composition, in patients with schistosomiasis who had undergone the same clinical and surgical treatments as the patients in the present study (18). This thiol-containing enzyme is highly sensitive to several oxidizing species, either directly or by crosslinking of its co-factor, apoAI (19), and so oxidative stress may contribute to the acquired lecithin-cholesterol acyltransferase deficiency and membrane disturbances (20) seen in human schistosomiasis.…”
Section: Htf Facundo Et Almentioning
confidence: 50%
“…Young patients (11)(12)(13)(14)(15)(16)(17)(18)(19)(20) years; N = 18) of both genders with hepatosplenic schistosomiasis mansoni, who had had upper digestive bleeding but no renal, cardiac, hepatitis, or other parasite/microbial associated disease were included in this study. They were outpatients at the Clinical Hospital, Federal University of Pernambuco (UFPE), Recife, and had been treated with the antischistosomal drug, oxamniquine (a single dose of 20 mg/ kg) followed by splenectomy, ligature of the left gastric vein and auto-implantation of spleen tissue into an omental pouch of the major omentum.…”
Section: Htf Facundo Et Almentioning
confidence: 99%