Role of metabolic control on diabetic nephropathy

Macedo, Célia Sperandeo; Capelletti, Sônia Maria; Mercadante, Maria Cecília Salgado; Padovani, Carlos Roberto; Spadella, César Tadeu

doi:10.1590/s0102-86502002000600003

Cited by 20 publications

(11 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The blood glucose level after alloxan injection reached to a higher level in our experiments (≥450 mg/dl) while others made partial diabetes with glucose level of about 350 mg/dl [15] or 200-250 mg/dl [40,41]. Our results indicate that transplanted cells could decrease the blood glucose level, although not to the normal level.…”

Section: Discussioncontrasting

confidence: 50%

Differentiation of mesenchymal stem cells to insulin-producing cells and their impact on type 1 diabetic rats

et al. 2010

View full text Add to dashboard Cite

Cell therapy is thought to be a possible approach for treatment of diabetes. Cells with the ability to differentiate into insulin-producing cells (IPCs) would provide an unlimited source of islet cells for transplantation. In this study, the differentiation capacity of rat bone-marrow-derived mesenchymal stem cells (MSCs) to IPCs and the feasibility of using them for reversal of hyperglycemia were investigated. In vitro studies indicated that treatment of cells with high glucose concentration, nicotinamide and beta-mercaptoethanol resulted to differentiated cells, which had characteristics of IPCs including spherical, grape-like morphology, secretion of insulin, and being positive for dithizone. To test the in vivo function of differentiated MSCs, they were injected into the spleen of diabetic rats. It was shown that diabetic rats who received IPCs, significantly reduced the glucose level, in response to intraperitoneal glucose tolerance (IPGT) test. These results indicate that MSCs are capable of in vitro differentiation into functional IPCs, which can reverse hyperglycemia in rat model of diabetes.

show abstract

Section: Discussioncontrasting

confidence: 50%

Differentiation of mesenchymal stem cells to insulin-producing cells and their impact on type 1 diabetic rats

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Other proteins, such as fibronectin, are present in the normal mesangium but increase in the expanding mesangium (Zeisbert et al, 2002). In addition to in diabetes, many mechanisms, such as cellular hemodynamic, and increase of formation of advanced glycation end products (Nishikawa et al, 2000) caused by hyperglycemia account for mesangial increase (Macedo et al, 2002). GSPE attenuates this accumulation mesangial matrix.…”

Section: Discussionmentioning

confidence: 99%

Grape seed proanthocyanidin extract ameliorates diabetic nephropathy in rats

Mansouri¹,

Panahi²,

Ghaffari³

et al. 2012

Sci. Res. Essays

View full text Add to dashboard Cite

This study examined the effects of grape seed proanthocyanidin extract (GSPE) on kidney of diabetic nephropathy rats. Male Sprague-Dawley rats were divided into three Groups: control, diabetic nephropathy, diabetic nephropathy and received GSPE 500 mg/kg for 6 weeks. At first, 24-h urinary albumin excretion (UAE) was studied two weeks after induction of diabetes then each week until the end of the experimental period in all of groups. At the end, the experimental animals were sacrificed and the right kidneys were collected and were prepared for light microscopy and electron microscopy evaluation. The results showed that the UAE and kidney weight in diabetic nephropathy rats were significantly higher than in control. Also an increase of the mesangial matrix, apoptotic cells, Bax expression, glomerular basement membrane thickness and broadening of foot process in diabetic nephropathy group rats were observed when compared to control group. These features were found to be reversed when the GSPE was administered to the experimental animals. Our results suggest that GSPE can prevent the progression of nephropathy in diabetic rats.

show abstract

“…One of the hallmarks of diabetes is high blood sugar [28]. Diabetes is a worldwide prevalent metabolic disease that affects the physical and psychological state of patients [29]. Diabetes mellitus is characterized by the insufficient secretion of insulin hormone [30] and the associated symptoms of weight loss, polyuria, polydipsia and polyphagia [31].…”

Section: Introductionmentioning

confidence: 99%

Genetic, dietary, and non-dietary risk factors of obesity among preparatory-year female students at Taibah University, Saudi Arabia

Nashar

Alananbeh

Hassan

2017

Journal of Taibah University for Science

View full text Add to dashboard Cite

Genetic factors have a strong influence on obesity and are associated with body mass index (BMI). No study has investigated the relationships between glucose, the fat mass and obesity-associated (FTO) gene, obesity (BMI), and other metabolic-related traits in Saudi Arabia. This study was conducted to identify the association between glucose, BMI and the FTO rs9939609 variant with different metabolic traits among 186 female preparatory students at Taibah University in 2015. The subjects were divided into two categories based on glucose level and BMI. The results showed that 1/10th of the students were non-obese, while approximately 1/3rd had a high glucose level (HGL). The HGL group had higher mean levels of glucose, cholesterol, triglycerides, HDL, LDL, VLDL, and malondialdehyde compared to those of the normal glucose level (NGL) group. A highly positive correlation between glucose and some biochemical parameters was found in the HGL group (P < 0.05), while no correlation was found between glucose and biochemical parameters, except for the cholesterol and triglyceride levels, in the NGL group. According to the t-test, none of the biochemical parameters were significant, and no correlation existed between these parameters and glucose, except for BMI. More than 90% of the students were not aware that they had an HGL or high cholesterol level according to their response to the questionnaire distributed at the beginning of this study. These problems mainly arose from the students' diet, lack of exercise, and lifestyle. Of the 75% of students that had the T-allele, approximately 50% had the heterozygous FTO rs9939609 genotype AT. Genotypes were in Hardy-Weinberg equilibrium (P > 0.05) in the whole population (n = 186) in both obese and non-obese groups and both HGL and NGL groups. In conclusion, a positive correlation between glucose and some biochemical parameters was found in the HGL group; 24.5% of the population had the (A allele) risk factor, and 32% and 98% of the population were homozygous (AA) and heterozygous (AT) for the rs9939609 FTO obesity-risk allele that is responsible for greater energy intake. Future studies are required to study the FTO gene variant and its association with different biochemical parameters, mainly glucose, weight, and BMI, between males and females at different ages and locations in Saudi Arabia.

show abstract

Role of metabolic control on diabetic nephropathy

Cited by 20 publications

References 17 publications

Differentiation of mesenchymal stem cells to insulin-producing cells and their impact on type 1 diabetic rats

Differentiation of mesenchymal stem cells to insulin-producing cells and their impact on type 1 diabetic rats

Grape seed proanthocyanidin extract ameliorates diabetic nephropathy in rats

Genetic, dietary, and non-dietary risk factors of obesity among preparatory-year female students at Taibah University, Saudi Arabia

Contact Info

Product

Resources

About