Estudo da ação do extrato de Ginkgo biloba e amido hidroxietílico hipertônico na atenuação de alterações decorrentes de isquemia e reperfusão de órgãos esplâncnicos em ratos

Macarenco, Ricardo; Takahagi, Rodrigo Ueno; Bardella, Luiz Carlos; Sequeira, Júlio Lopes; Yoshida, Winston Bonetti

doi:10.1590/s0102-86502001000300005

Cited by 8 publications

(9 citation statements)

References 10 publications

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“…Macarengo et al 4 observed that MABP significantly increased after occlusion of the celiac trunk, SMA and inferior mesenteric artery, returning to baseline values after 30 minutes. Simonian et al 13 reported that the occlusion a decrease in heart rate, gradually reversed during reperfusion and eventually returned to more elevated values than baseline.…”

Section: Discussionmentioning

confidence: 97%

“…Thus, the occlusion of these vessels results in severe ischemia in these organs 3 . Occlusion and reperfusion of the splanchnic arteries cause circulatory shock, especially due to an increase in vascular permeability, activation and adherence of polymorphonuclear neutrophils, release of proinflammatory substances, formation of reactive oxygen species (ROS) and reactive nitrogen species 4,5 . Mucosal injury, bacterial translocation and activation of inflammatory responses occur in the small intestine 6 , besides hydroelectrolytic disorders and acid-base imbalance in remote organs 7 .…”

Section: Introductionmentioning

confidence: 99%

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Systemic evaluation on ischemia and reperfusion injury of splanchnic organs in rats

Cerqueira¹,

Hussni

Yoshida

et al. 2009

Acta Cir. Bras.

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Purpose:To evaluate hemodynamic and systemic changes during and after splanchnic ischemia and reperfusion (I/R). Methods: Rats were divided into two groups: a) control: animals submitted to surgery, but not to I/R, treated with saline (5 ml/kg/h) for 150 min; b) group I/R: animals continuously infused with saline, and submitted to occlusion of the celiac trunk, superior mesenteric artery (SMA), and inferior mesenteric artery for 30 min, followed by a 120-min reperfusion. Mean arterial blood pressure (MABP), venous pressure, aortic and SMA blood flow, heart rate, esophageal temperature and hematocrit were evaluated. Results: During reperfusion in I/R groups, there was a progressive decrease in MABP, aortic blood flow, SMA blood flow, heart rate and esophageal temperature; vein pressure and hematocrit remained unchanged during the experiment. Conclusion: The model of ischemia used causes systemic changes, which are evidenced by hypotension, decrease in mesenteric blood flow, heart rate and esophageal temperature. Key words: Ischemia. Reperfusion. Intestine, Small. Shock. Rats. RESUMOObjetivo: Avaliar as alterações hemodinâmicas e sistêmicas decorrentes de isquemia e reperfusão (I/R) esplâncnica em ratos. Métodos: Vinte ratos foram divididos em dois grupos: grupo controle: os animais foram submetidos à cirurgia, mas não a I/R e foram tratados com solução fisiológica (5 ml/kg/h) por 150 minutos; grupo I/R: os animais foram submetidos à administração contínua de solução fisiológica e à oclusão do tronco celíaco, artéria mesentérica superior e artéria mesentérica inferior por 30 minutos, seguidos por 120 minutos de reperfusão. Avaliou-se a pressão arterial média, pressão venosa, fluxo sangüíneo na aorta e na artéria mesentérica superior, freqüência cardíaca, temperatura esofágica e hematócrito. Resultados: Durante a reperfusão, no grupo I/R, houve uma diminuição progressiva da pressão arterial média, fluxo sangüíneo na aorta e artéria mesentérica superior, freqüência cardíaca e temperatura esofágica; pressão venosa e hematócrito não sofreram alteração. Conclusão: O modelo de isquemia provocado por oclusão da artéria mesentérica superior, artéria mesentérica inferior e tronco celíaco por 30 minutos seguidos por 120 minutos de reperfusão provoca alterações sistêmicas evidenciadas por hipotensão, diminuição do fluxo sangüíneo mesentérico, da freqüência cardíaca e da temperatura esofágica. Descritores: Isquemia. Reperfusão. Intestino Delgado. Choque. Ratos.

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Systemic evaluation on ischemia and reperfusion injury of splanchnic organs in rats

Cerqueira¹,

Hussni

Yoshida

et al. 2009

Acta Cir. Bras.

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“…It is constituted by 24% of ginkgo flavone glycosides and 6% of terpenoids (FORLENZA, 2003). Ginkgo biloba has antioxidant mechanism of action (MACARENCO et al, 2001) and antiapoptotic activity (FORLENZA, 2003). It reduces clastogenic activity, has an anti-ischemic effect and causes vascular relaxation via nitrous oxide.…”

Section: Ginkgo Bilobamentioning

confidence: 99%

Phytotherapy: an introduction to its history, use and application

Ferreira

Moreira

Cária

et al. 2014

Rev. bras. plantas med.

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There has been a great advance in the pharmacognosy field, which has increased the use of medicinal plants by health professionals and practitioners of folk medicine. This systematic review explored the history and the present day application of phytotherapeutic medicines. We searched the databases Cochrane Library, Embase, Lilacs, PubMed, Scielo and a specialized bibliography. We concluded that there are many therapeutic potentialities in the use of phytotherapeutic medicines and medicinal plants. We also concluded that despite the increasing number of publications in the field each year, there is still a lack of reviews and meta-analyses that could promote a better integration of the knowledge produced. In addition, research about pharmacological interactions and multidisciplinary studies may promote a quicker and safer process from the workbench up to the clinical trials.Keywords: medicine history, herbal medicine, primitive medicine, phytotherapy. RESUMO: Fitoterapia: introdução a sua história, uso e aplicação. Diante do avanço que vem ocorrendo na área da farmacognosia, decorrente do aumento do uso de plantas medicinais na medicina popular e por profissionais da saúde, este trabalho apresenta uma revisão sistemática sobre a história dos fitoterápicos e sobre sua aplicação na atualidade. Foram realizadas buscas nas bases de dados Cochrane Library, Embase, Lilacs, PubMed, Scielo e em bibliografia especializada. Concluiu-se que, apesar da quantidade de estudos publicados crescer a cada ano, há ainda escassez de revisões e meta-análises que promovam melhor integração do conhecimento produzido. Pesquisas contemplando interações farmacológicas e trabalhos multidisciplinares podem acelerar os estudos em bases mais seguras, desde a bancada até os ensaios clínicos.Palavras-chave: história da medicina, ervas medicinais, medicina primitiva, fitoterapia.

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“…This reperfusion injury exacerbates the ischaemic damage of the intestinal microcirculation together with a negative outcome [10], [11]. Reperfusion of splanchnic arteries following occlusion may precipitate circulatory shock with the consequent activation and adhesion of polymorphonuclear neutrophils, release of proinflammatory substances and formation of both oxidative and nitrosative stress [12], [13], [14]. Intestinal ischaemia-reperfusion is a common pathway for many diseases and may lead to multiple organ dysfunction and death [15].…”

Section: Introductionmentioning

confidence: 99%

Preconditioning with Azadirachta indica ameliorates cardiorenal dysfunction through reduction in oxidative stress and extracellular signal regulated protein kinase signalling

Omóbòwálé

Oyagbemi

Adejumobi

et al. 2016

Journal of Ayurveda and Integrative Medicine

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BackgroundAzadirachta indica is widely distributed in Africa, Asia and other tropical parts of the world. A. indica (AI) is traditionally used for the treatment of several conditions including cancer, hypertension, heart diseases and skin disorders. Intestinal ischaemia-reperfusion is a common pathway for many diseases and may lead to multiple organ dysfunction syndrome and death.ObjectiveIn this study, we investigated the ameliorative effects of AI on intestinal ischaemia-reperfusion injury-induced cardiorenal dysfunction.Materials and methodsSixty rats were divided into 6 groups; each containing 10. Corn oil was orally administered to group A (control) rats for 7 days without intestinal ischaemia-reperfusion injury. Group B underwent intestinal ischaemia-reperfusion injury (IIRI) without any pre-treatment. Groups C, D, E and F were pre-treated orally for 7 days with 100 mg/kg AI (100 and (200 mg/kg) vitamin C (100 and 200 mg/kg) respectively and thereafter underwent IIRI on the 8th day.ResultsThe cardiac and renal hydrogen peroxide increased significantly whereas serum xanthine oxidase and myeloperoxidase levels were significantly elevated (p < 0.05) in IIRI only when compared to the control. The cardiac and renal reduced glutathione, glutathione peroxidase, protein thiol, non-protein thiol and serum nitric oxide (NO) decreased (p < 0.05) significantly following IIRI. Immunohistochemical evaluation of cardiac and renal tissues showed reduced expressions of the extracellular signal regulated kinase (ERK1/2) in rats with IIRI only. However, pre-treatment with A. indica and vitamin C significantly reduced markers of oxidative stress and inflammation together with improvement in antioxidant status. Also, reduced serum NO level was normalised in rats pre-treated with A. indica and vitamin C with concomitant higher expressions of cardiac and renal ERK1/2.ConclusionsTogether, A. indica and vitamin C prevented IRI-induced cardiorenal dysfunction via reduction in oxidative stress, improvement in antioxidant defence system and increase in the ERK1/2 expressions. Therefore, A. indica can be a useful chemopreventive agent in the prevention and treatment of conditions associated with intestinal ischaemia-reperfusion injury.

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Estudo da ação do extrato de Ginkgo biloba e amido hidroxietílico hipertônico na atenuação de alterações decorrentes de isquemia e reperfusão de órgãos esplâncnicos em ratos

Cited by 8 publications

References 10 publications

Systemic evaluation on ischemia and reperfusion injury of splanchnic organs in rats

Systemic evaluation on ischemia and reperfusion injury of splanchnic organs in rats

Phytotherapy: an introduction to its history, use and application

Preconditioning with Azadirachta indica ameliorates cardiorenal dysfunction through reduction in oxidative stress and extracellular signal regulated protein kinase signalling

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