Efeito da vagotomia troncular em ratos injetados na fase neonatal com glutamato monossódico: estudo biométrico

Souza, Fernando O.; Marchesini, João Batista; Campos, Antônio Carlos; Malafaia, Osvaldo; Monteiro, Orlando; Ribeiro, Fernando Brenha; Alves, Helvércio Fernando Polsaque; Siroti, Fernando Jorge; Meister, Hugo; Mathias, Paulo Cézar de Freitas

doi:10.1590/s0102-86502001000100006

Cited by 7 publications

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References 18 publications

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“…These data are in accordance to what one would expect to find in the literature 7,25,27 . Hermanussen et al 7 , administering MSG on the 3rd week of gestation, has shown similar results with lower weight at birth and with 30 days of life in the intervention group, using a dose of 5g of MSG orally.…”

Section: Discussionsupporting

confidence: 93%

“…IL is equivalent, for rats as the BMI used in humans, which takes into consideration the mass distribution through the body surface. IL in rats is calculated through the cubic root of the weight (in g) divided by the height (in cm) (nasal-anal distance -NAL) and multiplied by 1.000 [25][26][27] . IL at birth in the GC is significantly larger than the one in the G20 (p < 0.05).…”

Section: Discussionmentioning

confidence: 99%

“…They also evidenced lower weight and stature and higher IL in relation to the controls. Souza et al 27 , using MSG subcutaneously in newly born, found, already in the 30th day of life, lower NAL and higher IL in the intervention group in relation to the control. FIGURE 4 -Percentage of NAL increase from birth until the 21 st day of life of the offspring of rats which had a consumption of ration with MSG being added in the concentrations of 20% (G20), 10% (G10) and pure ration (GC), decreasing among the groups GC, G10 and G20, respectively (p < 0,01) TABLE 2 -Weight and NAL increase percentage from birth until the 21 st day of life of the offspring of rats which had a consumption of ration with MSG being added in the concentrations of 20%(Group 20%), 10% (Group 10%) and pure ration (Control Group).…”

mentioning

confidence: 97%

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Effect of the oral administration of monosodium glutamate during pregnancy and breast-feeding in the offspring of pregnant Wistar rats

Diemen

Trindade

2010

Acta Cir. Bras.

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Effect of the oral administration of monosodium glutamate during pregnancy and breast-feeding in the offspring of pregnant Wistar ratsABSTRACT Purpose: Determine the effects of the MSG (monosodium glutamate) in the offspring of pregnant rats through the comparison of the weight, NAL (nasal-anal length) and IL (Index of Lee) at birth and with 21 days of life. Methods: Pregnant Wistar rats and their offspring were divided into 3 groups: GC, G10 and G20. Each of the groups received 0%, 10% and 20% of MSG, respectively from coupling until the end of the weaning period. Results: Neither weight nor NAL were different among the groups at birth. The group G20 at birth had an IL lower than the group GC (p<0,05) and with 21 days of life presented weight and NAL lower than the groups G10 and this lower than the GC (p<0,01). Otherwise the G20 at 21 days of life had the IL similar to the other two groups. The weight profit percentage from birth to the 21 st day of life was lower in the G20 regarding the other two groups (p<0,01). The G20 had a NAL increase percentage from birth to the 21 st day of life lower than the G10 and this lower than the GC (p<0,01). Conclusions: MSG presented a dose-dependent relation in the variables weight and NAL. It caused a decrease in the growth pattern as well as in the weight gain pattern until the 21 st day of life. The IL of the group 20% had an increased in relation to the control group after 3 weeks of follow up. Key words: Obesity. Sodium Glutamate. Pregnancy. Rats. RESUMO Objetivo:Avaliar o efeito do glutamato monossódico (GMS) nos fetos de ratas prenhes por meio da comparação do peso, comprimento nasal-anal (CNA) e índice de Lee (IL) ao nascimento e com 21 dias de vida. Métodos: Foram utilizadas ratas prenhes da linhagem Wistar distribuídas em três grupos: grupo controle (GC), G10 e G20. Estes, respectivamente, foram alimentados com ração contendo 0, 10 e 20% de GMS desde o período de acasalamento até o final da amamentação. Resultados: O peso e o CNA não foram diferentes entre os grupos ao nascimento. O grupo G20, ao nascimento, teve IL menor que o grupo GC (p < 0,05) e, aos 21 dias de vida, apresentou peso e CNA menores que o grupo G10, o qual foi menor que o GC (p < 0,01). O grupo G20, aos 21 dias de vida, teve IL semelhante aos outros dois grupos. O percentual de ganho de peso do nascimento ao 21º dia de vida foi menor no G20 em relação aos outros dois grupos (p < 0,01). O grupo G20 teve percentual de aumento de CNA do nascimento ao 21º dia de vida menor que o grupo G10, e este menor que o grupo GC (p < 0,01). Conclusões: O GMS nas concentrações de 10 e 20% na ração de ratas prenhes Wistar apresentou uma relação dosedependente nas variáveis peso e CNA. Houve diminuição no padrão de ganho de peso e de aumento de CNA do nascimento ao 21º dia de vida com uso de GMS. O IL na prole do grupo G20 aumentou em relação ao do grupo GC após 3 semanas de acompanhamento. Descritores: Obesidade. Glutamato de Sódio. Gravidez. Ratos.1 Research performed at the Experimental Research Center, Clinics ...

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 97%

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Effect of the oral administration of monosodium glutamate during pregnancy and breast-feeding in the offspring of pregnant Wistar rats

Diemen

Trindade

2010

Acta Cir. Bras.

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“…Souza et al . 24 showed that vagotomy promotes weight loss and reduced food intake more importantly in the first postoperative days, one of the explanations for this fact is that the procedure blocks the feeding inhibitory effect, consequently, these animals ingest smaller amounts and more frequent portions of liquid diet, and larger amounts and less frequent portions of solid diet, possibly explained by the reduction in tone of the pyloric sphincter. in addition, vagal activities are associated with gastric emptying 25 , 26 .…”

Section: Discussionmentioning

confidence: 99%

Vagotomy associated with splenectomy reduces lipid accumulation and causes kidneys histological changes in rats with hypothalamic obesity

et al. 2021

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Purpose To evaluate the influence of autonomic vagal and splenic activities on renal histomorphometric aspects in obese rats. Methods Thirty male Wistar rats were used, of which, 24 received subcutaneous injections of monosodium glutamate (MSG) during the first 5 days of life (4 g/kg body weight) and six control animals received injections of saline solution (CON). Five experimental groups were organized (n = 6/group): falsely-operated control (CON-FO); falsely-operated obese (MSG-FO); vagotomized obese (MSG-VAG); splenectomized obese (MSG-SPL); vagotomized and splenectomized obese (MSG-VAG-SPL). Results The MSG-FO group animals showed a significant reduction in body weight and nasal-anal length when compared to CON-FO group animals (p < 0.05). The MSG-VAG-SPL group showed significant reduced in most biometric parameters associated with obesity. Falsely-operated obese animals showed a significant reduction in renal weight, glomerular diameters, glomerular tuff and capsule areas and Bowman’s space compared to CON-FO group animals (p < 0.05). There was a significant reduction in diameter, glomerular tuft and capsule areas, and Bowman’s space in MSG-VAG, MSG-SPL, MSG-VAG-SPL groups when compared to the MSG-FO group. Conclusions Vagotomy associated with splenectomy induces a reduction in the adiposity and causes histological changes in the kidney of obese rats.

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“…Although the animals receiving the hypercaloric diet did not have an increase in body weight, they also had an increase in visceral fat. 11 This is mainly due to the fact that animals receiving a hypercaloric diet reduce their daily food intake, but, because of the high amount of carbohydrates and fat contained in the cafeteria diet, visceral fat builds up. 12 The increase in cardiovascular risk is more associated with the distribution of visceral fat than with the mere increase in body weight.…”

Section: Discussionmentioning

confidence: 99%

Efeito da associação entre obesidade neuroendócrina e exócrina experimental sobre a pressão arterial de cauda e o metabolismo de glicose de ratos Wistar

Pastore¹,

Cesaretti²,

Ginoza³

et al. 2010

J. Bras. Nefrol.

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Objective: To study two different models of obesity, exocrine and endocrine, and its association on tail arterial pressure (TAP), body weight (BW), glucose metabolism and visceral fat content. Methods: Male Wistar rats were studied. The MSG group was composed by rats that received of MSG in neonatal period. At the 3rd month of life, part of these animals received cafeteria diet. Animals received saline control in the neonatal period. In the 12 weeks of study, body weight and blood pressure were measured twice a week. In the end of this period on, Oral Glucose Tolerance Test (OGTT) was performed and the Insulin Sensitivity Index (ISI) was calculated, also the left Relative Ventricular Weight (RLW) and Relative Epididimal Fat Weight (REFW) were obtained. Results: No changes on BW and TAP were verified. The obesity induced by MSG and CAF, individually, let to increases on insulin resistance (WST = 23,25 ± 9,31; CAF = 15,92 ± 9,10*; MSG = 13,41 ± 3,84* mg-1mU-1, p < 0,05 vs WST) and relative epididimal fat content (WST = 6,20 ± 0,57; CAF = 8,27 ± 1,53*; MSG = 8,23 ± 1,98* g/100 g, *p < 0,05) when these rats were compared to control rats. An enhanced effect upon these parameters was observed with the association of both obesity models (MSG+CAF = 9,34 ± 5,77 mg1mU-1, p < 0,05 vs MSG and CAF) and visceral fat content (MSG+CAF = 11,12 ± 3,85 g/100g, p < 0,05 vs MSG and CAF). Conclusion: The association of these two experimental models of obesity aggravates insulin resistance that probably is due at least in part to the increase of visceral fat content.

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Efeito da vagotomia troncular em ratos injetados na fase neonatal com glutamato monossódico: estudo biométrico

Cited by 7 publications

References 18 publications

Effect of the oral administration of monosodium glutamate during pregnancy and breast-feeding in the offspring of pregnant Wistar rats

Effect of the oral administration of monosodium glutamate during pregnancy and breast-feeding in the offspring of pregnant Wistar rats

Vagotomy associated with splenectomy reduces lipid accumulation and causes kidneys histological changes in rats with hypothalamic obesity

Efeito da associação entre obesidade neuroendócrina e exócrina experimental sobre a pressão arterial de cauda e o metabolismo de glicose de ratos Wistar

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