2000
DOI: 10.1590/s0102-86502000000100001
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Abstract: Foi realizado clampeamento do pedículo hepático de rato por diferentes tempos e estudadas as repercussões nos intestinos. Para tanto foram utilizados 40 ratos, machos, divididos em quatro grupos de 10 animais cada. O grupo S (Sham) não foi submetido a isquemia, já os grupos E1, E2 e E3 sofreram isquemia de 10, 20 e 30 minutos respectivamente. Nossos resultados mostraram alterações macroscópicas quanto a cor dos intestinos nos grupos E2 (20') e E3 (30') e histopatológicas que ocorreram em cada um desses grupos.… Show more

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Cited by 5 publications
(5 citation statements)
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“…They described the damage of anastomotic healing of the left colon with higher mortality rate. Sébe et al 12 also studied the effects of clamping the hepatic pedicle in small and large bowels and observed the same mucosal damage as we did. Thirty minutes after release of the hepatic pedicle clamping it was observed the detachment of the epithelium at the top of the intestinal villi and the presence of hemorrhage with intense leukocyte infiltration.…”
Section: ■ Discussionsupporting
confidence: 82%
See 1 more Smart Citation
“…They described the damage of anastomotic healing of the left colon with higher mortality rate. Sébe et al 12 also studied the effects of clamping the hepatic pedicle in small and large bowels and observed the same mucosal damage as we did. Thirty minutes after release of the hepatic pedicle clamping it was observed the detachment of the epithelium at the top of the intestinal villi and the presence of hemorrhage with intense leukocyte infiltration.…”
Section: ■ Discussionsupporting
confidence: 82%
“…They found a higher mortality of the animals because of an increased risk of anastomotic leakage after colonic resection. It is well known that venous portal or mesenteric obstruction followed by reperfusion trigger a huge burst of oxygen-derived free radicals producing deleterious effects on the healing processes of anastomotic wound in the intestinal wall [10][11][12] . Besides, oxidative stress may worsen the former lesions with local and systemic effects 10,11 .…”
Section: ■ Discussionmentioning
confidence: 99%
“…As Sebe et al 12 hemorrhage of lamina propria and epithelial layer of large areas of the intestinal villi of mice occurred at 30 minutes of pedicle clamping, whose time was earlier than in the present study, probably due to complete portal occlusion.…”
Section: Discussionsupporting
confidence: 46%
“…Sebe et al 12 studied the histopathological changes of the small intestine into three groups of rats subjected to total occlusion of the hepatic pedicle for 10, 20 and 30 minutes, and also observed that the intensity of splanchnic congestion was proportional to the time of stasis, whereas the control group, not subjected to occlusion of the pedicle vessels, presented with typical lamina propria lymphocytes and few plasma cells, and without dilation of blood vessels and lymphatics. With 10 minutes of total occlusion, the histological features were almost normal, with only lymphoplasmacytic infiltration and mild vascular dilation, which became intense with 20 minutes of total occlusion.…”
Section: Discussionmentioning
confidence: 99%
“…Sebe et al conducted the study on assessing the histological changes of the small intestine during clamping of the PT in rats (10, 20 and 30 minutes). It was determined that significant morphological changes in the structure of the small intestine (especially in the mucous membrane, in addition to the submucosa, muscle and serous layers) appear only after 30 minutes after clamping (20). However, it should be noted that histological materials were taken immediately after performing PT clamping.…”
Section: Introductionmentioning
confidence: 99%