Ondas ultra-sônicas de alta freqüência causam disfunção endotelial em artérias coronárias caninas epicárdicas

Discigil, Berent; King, Robert D.; Pearson, Paul J.; Capellini, Verena Kise; Rodrigues, Alfredo José; Schaff, Hartzell V.; Évora, Paulo Roberto Barbosa

doi:10.1590/s0102-76382008000200007

Cited by 2 publications

(1 citation statement)

References 24 publications

(34 reference statements)

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“…Vascular spasm is likely augmented by the loss of vascular relaxation in response to endothelial damage and cessation of endothelial cell synthetic function. In a series of ex vivo experiments in canine coronary arteries, vascular relaxation was lost as a result of endothelial damage and disruption of the nitric oxide signalling pathways, but mechanisms of relaxation remain intact in the vascular smooth muscle and can be activated by the administration of exogenous nitric oxide donors, isolating the cause as endothelial damage [31].…”

Section: Effect Of High-intensity Focused Ultrasound On Blood Flowmentioning

confidence: 99%

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

Shaw

Haar

Rivens

et al. 2014

J. R. Soc. Interface.

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ReviewCite this article: Shaw CJ, ter Haar GR, Rivens IH, Giussani DA, Lees CC. 2014 Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery. J. R. Soc. High-intensity focused ultrasound (HIFU) is a non-invasive technology, which can be used occlude blood vessels in the body. Both the theory underlying and practical process of blood vessel occlusion are still under development and relatively sparse in vivo experimental and therapeutic data exist. HIFU would however provide an alternative to surgery, particularly in circumstances where serious complications inherent to surgery outweigh the potential benefits. Accordingly, the HIFU technique would be of particular utility for fetal and placental interventions, where open or endoscopic surgery is fraught with difficulty and likelihood of complications including premature delivery. This assumes that HIFU could be shown to safely and effectively occlude blood vessels in utero. To understand these mechanisms more fully, we present a review of relevant cross-specialty literature on the topic of vascular HIFU and suggest an integrative mechanism taking into account clinical, physical and engineering considerations through which HIFU may produce vascular occlusion. This model may aid in the design of HIFU protocols to further develop this area, and might be adapted to provide a non-invasive therapy for conditions in fetal medicine where vascular occlusion is beneficial.

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Section: Effect Of High-intensity Focused Ultrasound On Blood Flowmentioning

confidence: 99%

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

Shaw

Haar

Rivens

et al. 2014

J. R. Soc. Interface.

View full text Add to dashboard Cite

show abstract

Experimental Substantiation of the Use of HIFU Technology in the Treatment of the Lower Limb Varicose Disease

Tsibin

Беркович²,

Bursian³

et al. 2022

Biomed Eng

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Ondas ultra-sônicas de alta freqüência causam disfunção endotelial em artérias coronárias caninas epicárdicas

Cited by 2 publications

References 24 publications

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

Pathophysiological mechanisms of high-intensity focused ultrasound-mediated vascular occlusion and relevance to non-invasive fetal surgery

Experimental Substantiation of the Use of HIFU Technology in the Treatment of the Lower Limb Varicose Disease

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