Corniculatin A, a new flavonoidal glucoside from Oxalis corniculata

Ibrahim, Muhammad; Hussain, İqbal; Imran, Muhammad; Hussain, Nusrat; Hussain, Amjad; Mahboob, Tabassum

doi:10.1590/s0102-695x2013005000059

Cited by 20 publications

(5 citation statements)

References 8 publications

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“…The dried leaves were ground to a powder and passed through a 1-mm sieve. The powder was defatted using pure hexane ( 18 ). The defatted powder (4.5 kg) was placed in a Soxhlet extractor with pure ethanol.…”

Section: Methodsmentioning

confidence: 99%

The study of structure and effects of two new proanthocyanidins from Anogeissus pendula leaves on rumen enzyme activities

et al. 2023

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Two novel proanthocyanidins, (2R, 3R)-(+)-Gallocatechin-(4β → 8)4-(2R, 3R)-(+)-gallocatechin (compound 1) and 3-O-galloyl-(2S, 3S)-(–)-epicatechin-(4α → 8)-[3-O-galloyl-(2S, 3S)-(–)-epicatechin (4α → 8)]2-(2S, 3S)-(–)-epicatechin (compound 2), were structurally characterized from leaves of Anogeissus pendula. The structures were determined by ultraviolet spectroscopy (UV), proton nuclear magnetic resonance (1H NMR), 13C NMR, and heteronuclear multiple bond correlation. Molinspiration and Osiris property explorer applications were used to predict bioactivity and drug score. Drug scores of 0.08 and 0.05 were predicted for compounds 1 and 2, respectively. Predicted bioactivity scores were high. Due to their molecular weight, chemical structure, and conformation, the newly discovered proanthocyanidins possess an inclination to interact with proteins. Based on this premise, both compounds were subjected to in vitro testing against ruminal enzymes. They exhibited significant inhibition activities (p < 0.01) with a range of half maximal effective concentration (EC50) of 14.80–17.88 mg/mL of glutamic oxaloacetic transaminase in both protozoa and bacteria fractions. The ruminal glutamic pyruvic transaminase activity was significantly inhibited (p < 0.01) from EC50 12.59–16.29 mg/mL, and R-cellulase inhibition was recorded with EC50 18.20–21.98 mg/mL by compounds 1 and 2, respectively. Protease activity decreased with increasing incubation time and concentration of both compounds. The novel proanthocyanidins have potential roles in improving feed conversion ratios and in drug development.

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Section: Methodsmentioning

confidence: 99%

The study of structure and effects of two new proanthocyanidins from Anogeissus pendula leaves on rumen enzyme activities

et al. 2023

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“…Corniculatin A was isolated from the ethyl acetate-soluble region of the complete plant. [23] The existence of Kaempferol-3-sophorotrioside, quercetin-3-(caffeoyldiglucoside)-7-glucoside, isorhamnetin-3-caffeoyl-7-glucoside, and p-coumaric acid was reported by Zeb A and Imran M. [23] Khan et al also reported the OCME was found to include flavonoids, alkaloids, terpenoids, saponins, cardiac glycosides, phlobatannins, and steroids, but no tannins. The estimated total phenolic content was 7.76 ± 0.36 mg gallic acid equivalents per gram of extract, whereas the total flavonoid content was 6.92 ± 0.52 mg rutin equivalents per gram of extract.…”

Section: Phytochemical Profilementioning

confidence: 98%

Untitled

2023

IJGP

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One of the most recent focal plant species in India is Oxalis corniculata Linn, often known as creeping woodsorrel and a member of the family Oxalidaceae. It is a native to tropical and subtropical areas of the globe and is significant in medicine. Several conventional medical practices have used the herb O. corniculata Linn. to cure human illnesses and afflictions. The review is designed to assess the publication based on the research review on O. corniculata. The literature for a decade from 2011 to 2021 was collected from scientific databases such as PubMed, PubMed Central, Scopus, Science Direct, and Google Scholar. A methodical search was performed using various keywords in order to get a deeper insight into the database. The review indicates that several phytochemical compounds, including flavonoids, tannins, phytosterols, phenol, glycosides, fatty acids, galacto-glycerolipids, and volatile oil, have been isolated from the plant. The leaves are rich in flavonoids, isovitexine, and vitexine-2"-Obeta-D-glucopyranoside. It is an abundant supply of important fatty acids such as palmitic acid, oleic acid, linoleic acid, linolenic acid, and stearic acid. The chemical structure of the identified compound given in the literature was sketched using the chem sketch freeware version, which would help the researchers to study the chemical nature of the compound in reference to identifying the lead molecule for further designing the semisynthetic derivatives with optimized activity. Also from the literature, it has been revealed that different parts of O. corniculata were assessed for pharmacological activities and found to possess antidiabetic activity, wound healing activity, antioxidants, anxiolytic properties, protective effect on induced nephrotoxicity, and antibacterial activity. The major focus of the review was to identify the folkloric uses of the plant that were reported in the published study. For a long time, traditional medicinal practitioners have used the plant to treat bad breath and is a rich source of Vitamin C for the treatment of Vitamin C deficiency for the treatment of stomach disorders in the area of the Cold Desert of Western Himalaya, Traditional healers from many locations reportedly used it to treat cataracts, sinusitis, conjunctivitis, and typhoid. The plant is utilized for athlete's foot, wounds, hypertension, diabetes, and hormonal imbalance; stomachache and migraine; excessive menstruation; cough; and poison antidote; as a blood tonic to be taken orally; intestinal gas; stomach discomfort; renal pain; kidney stone; and strengthening urinary tract wall; as a therapy for fractures and snakebites; as utilized to cure renal conditions; leaf paste to promote speedy healing; topically to cure worms and scorpion stings; and skin ailments; utilized to cure renal conditions; topically to cure worms; and scorpion stings; and skin ailments; therapeutic characteristics, such as astringent; and hemorrhoea.

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“…Corniculatin A was isolated from an EtOAc extract of the whole plant, together with luteolin, luteolin-7-O-β-D-glucoside, and β-sitosterol-3-O-β-D-glucoside [56].…”

Section: Chulco Trebol Trebol De Huertamentioning

confidence: 99%

Poorly Investigated Ecuadorian Medicinal Plants

Armijos

Ramírez

Vidari

2022

Plants

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Ecuador has, in proportion of its size, one of the richest floras of Latin America and the world; the country also has an immense cultural heritage due to the presence of different ethnic groups that have implemented the use of many wild and cultivated plants, mainly as medicinal remedies. In a recent publication, we have summarized the results of research activities recently carried out on about 120 plants native to Ecuador, which includes the structures of non-volatile isolated compounds, as well as the chemical composition of essential oils (EOs) and the in vitro tested biological activity data. For the sake of completeness, we have collected in this paper the main information obtained from recent ethnobotanical investigations on other important Ecuadorian medicinal plants for which phytochemical, pharmacological, and toxicological studies are, however, still largely lacking. Thus, one of the objectives of this paper is to preserve the traditional knowledge of Ecuadorian Indigenous communities which, being transmitted orally, is in danger of becoming lost. Moreover, it is our intention to stimulate more extensive studies on the rich medicinal flora of the country, which can provide economic and social benefits, especially to the people who traditionally cultivate or collect the plants.

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Corniculatin A, a new flavonoidal glucoside from Oxalis corniculata

Cited by 20 publications

References 8 publications

The study of structure and effects of two new proanthocyanidins from Anogeissus pendula leaves on rumen enzyme activities

The study of structure and effects of two new proanthocyanidins from Anogeissus pendula leaves on rumen enzyme activities

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Poorly Investigated Ecuadorian Medicinal Plants

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