The genus Crataegus: chemical and pharmacological perspectives

Kumar, Dinesh; Arya, Vikrant; Bhat, Zulfiqar Ali; Khan, Nisar Ahmad; Prasad, Devendra

doi:10.1590/s0102-695x2012005000094

Cited by 86 publications

(61 citation statements)

References 73 publications

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“…Growing evidence has shown that the plant interesting pharmacological activities are due to the presence of proanthocyanidins and flavonoids (Jalali & Hasanzadeh, ). Additional constituents of the plant include triterpenes, polysaccharides and catecholamines (Kumar et al, ). However, there is yet no information about the possible effect of the phenolic compounds that are unique to C. monogyna on the testis.…”

Section: Crataegus Monogynamentioning

confidence: 99%

Plants in the management of male infertility

Onuah

Singh

2020

Andrologia

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This review attempts to collate existing data and provide the perspectives for future studies on the effects of plants on the male gonads. For many of these medicinal plants such as Lepidium meyenii, Rupus coreanus, Tribulus terrestres, Panax ginseng, Petasites japonicas, Apium graveolens, Eurycoma longifólia, Pedalium murex, Corchorus depressus, Mucuna pruriens, Astragalus membranaceus, Nigella sativa, Crataegus monogyna, Fagara tessmannii, Phaleria macrocarpa, Anacyclus pyrethrum, Cynomorium songaricum and Morinda officinalis, the mechanism of actions of their active principles and crude extracts has been shown in both laboratory animals, in vitro, and human studies, and includes their antioxidant, anti‐inflammatory, spermatogenesis‐inducing, aphrodisiac, smooth muscle relaxing and androgenic properties. Several active chemical leads including glucosinolates, anthocyanins, protodioscin, ginsenosides, sesquiterpenes, phyto‐oestrogens, quassinoids, diosgenin, thymoquinone, proanthocyanidins and bajijiasu isolated from these plants are known to have target effects on the testis, but efforts have been limited in their application at the clinical level. There still appear to be many more extracts of medicinal plants that have not been characterised to determine the phytochemicals unique to them that have target effects on the gonads. Further, collaborative efforts at isolating pro‐drug candidates from medicinal plants for studies at the molecular, cellular and clinical level towards elucidating their mechanisms of action on the testes are therefore warranted in the light of the current male fertility crisis.

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Section: Crataegus Monogynamentioning

confidence: 99%

Plants in the management of male infertility

Onuah

Singh

2020

Andrologia

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“…This was evidenced by several studies have been done on these plants, including the results of dekokta leaves and unripe fruit of the plant Crataegus mice induced Streptozotocin diabetes to produce the effect of normalizing the value of plasma lipid peroxides and lowering blood glucose levels in diabetes. 17 …”

Section: Plants Containing Vitexin Are Camellia Sinensis (Tea) Clinamentioning

confidence: 99%

Indonesian Herbal SGLT2 Inhibitor Discovery through Pharmacophore-Based Virtual Screening

Rezwendy

Syahdi²,

Yanuar³

2018

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Objective: Sodium-glucose cotransporter 2 (SGLT2) inhibitor had been evaluated in clinical trials as the basic strategy of hyperglycemia handling in diabetes. However, because of SGLT2 inhibitors is the new class of oral antidiabetic, it is rare to be found in Indonesia, and it is costly.This study was intended to find compounds from Indonesian herbal database that show capability to be used as SGLT2 inhibitors through a pharmacophore-based virtual screening approach. Methods: The SGLT2 inhibitor pharmacophore models were made from 10 training sets of SGLT2 ligand inhibitors using the Ligand Scout 4.1.5. Ten pharmacophore models which had been made were validated using test set and decoy set methods to know how the performance of pharmacophore model worked. Virtual screening were then applied to the best pharmacophore model. Results: The model-1 pharmacophore was the best model, with values of 0.9080, EF1% = 56.5, EF5% = 56.5 and AUC100% = 0.87 which served as model for virtual screening. Model-1 consisted of one hydrophobic interaction, one aromatic ring, four hydrogen bond donors and five hydrogen bond acceptors. Virtual screening showed three compounds (Hits) with best pharmacophore fit scores according to model-1 among 1377 compounds, they were vitexin = 113.62; cucumerin A = 112.62; and cucumerin B = 113.51. Conclusion: These results showed that vitexin, cucumerin A, and cucumerin B potentially have activity as an SGLT2 inhibitor..

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“…comprises of a complex group of trees and shrubs, native to northern temperate zones, mostly between latitudes 30 and 50 N. [1] Hawthorn belongs to the Maloideae subfamily in the Rosaceae family, a natural group of complex genera with the ability to interbreed freely (hybridize). [1] The genus Crataegus, which has been described as the largest genus of the Maloideae subfamily, includes more than 265 hawthorn species. [2] According to Christensen, [3] the Crataegus species' number could vary between 150 and 1200.…”

Section: Introductionmentioning

confidence: 99%

Genetic variation of some hawthorn species based on phenotypic characteristics and RAPD marker

Erfani‐Moghadam

Mozafari

Fazeli

2015

Biotechnology & Biotechnological Equipment

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Hawthorn (Crataegus spp.) is an important forest fruit species in Iran. Genetic variability among some genotypes of hawthorn was investigated using morphological traits and random amplified polymorphic DNA (RAPD) marker. The collected genotypes belonged to four species of Crataegus genus. High variability among genotypes was found for most of the traits. Results from the principal component analysis (PCA) indicated that 85.05% of the observed variability was accounted by the first five components. The first two components explained about 55.24% of the total achieved variability. In PCA, fruit weight, fruit length, fruit diameter, fruit moisture, fruit dry matter, leaf length, leaf area, leaf width, number of leaves per node, seed weight and seed length were predominant in the first two components, indicating that they were useful for the assessment of hawthorn germplasm characterization. A total of 58 polymorphic bands were produced with 10 RAPD primers. The bands' sizes ranged from 180 to 2700 bp. The number of the observed polymorphic bands for each primer ranged from 4 to 8, with an average of 5.8 alleles per locus. The polymorphism information content was observed to be the highest (0.79) in the Oligo_32 locus, whereas the Oligo_339 locus had the lowest value of 0.64, with an average of 0.72, among the RAPD primers. The Jaccard's genetic similarity coefficient ranged from 0.12 to 0.95 among the genotypes. At a similarity coefficient of 0.46, the unweighted pair group method with arithmetic mean (UPGMA) cluster analysis divided the genotypes into three major groups.

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The genus Crataegus: chemical and pharmacological perspectives

Cited by 86 publications

References 73 publications

Plants in the management of male infertility

Plants in the management of male infertility

Indonesian Herbal SGLT2 Inhibitor Discovery through Pharmacophore-Based Virtual Screening

Genetic variation of some hawthorn species based on phenotypic characteristics and RAPD marker

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