Morphoanatomy and pharmacognostic study of the wood of Croton echioides, the Northeastern Marapuama

Novello, Cláudio Roberto; Marques, Luís Carlos; Miyazaki, Cristine R.; Milaneze-Gutierre, Maria Auxiliadora; Carneiro‐Torres, Daniela Santos; Sarragiotto, María Helena; Mello, João Carlos Palazzo de

doi:10.1590/s0102-695x2012005000062

Cited by 6 publications

(6 citation statements)

References 25 publications

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“…Fatty acids such as uncosanoic, tricosanoic, and pentacosanoic acids account for up to 20% of the total lipophilic components of the plant [ 261 ]. Other compounds detected in muirapuama are fatty acid esters of sterols, coumarin, free fatty acids, and free sterol; a small quantity of β-sitosterol was also detected [ 262 ]. Based on ethnopharmacological data, it can be hypothesized that muirapuama interacts with the dopaminergic system, increasing libido; the noradrenergic system, inducing antidepressant effects; and the serotonergic system, modulating appetite.…”

Section: Discussionmentioning

confidence: 99%

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects

et al. 2020

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Sexual enhancers increase sexual potency, sexual pleasure, or libido. Substances increasing libido alter the concentrations of specific neurotransmitters or sex hormones in the central nervous system. Interestingly, the same pathways are involved in the mechanisms underlying many psychiatric and neurological disorders, and adverse reactions associated with the use of aphrodisiacs are strongly expected. However, sexual enhancers of plant origin have gained popularity over recent years, as natural substances are often regarded as a safer alternative to modern medications and are easily acquired without prescription. We reviewed the psychiatric and neurological adverse effects associated with the consumption of herbal aphrodisiacs Areca catechu L., Argemone Mexicana L., Citrus aurantium L., Eurycoma longifolia Jack., Lepidium meyenii Walp., Mitragyna speciosa Korth., Panax ginseng C. A. Mey, Panax quinquefolius L., Pausinystalia johimbe (K. Schum.) Pierre ex Beille, Piper methysticum G. Forst., Ptychopetalum olacoides Benth., Sceletium tortuosum (L.) N. E. Brown, Turnera diffusa Willd. ex. Schult., Voacanga africana Stapf ex Scott-Elliot, and Withania somnifera (L.) Dunal. A literature search was conducted on the PubMed, Scopus, and Web of Science databases with the aim of identifying all the relevant articles published on the issue up to June 2020. Most of the selected sexual enhancers appeared to be safe at therapeutic doses, although mild to severe adverse effects may occur in cases of overdosing or self-medication with unstandardized products. Drug interactions are more concerning, considering that herbal aphrodisiacs are likely used together with other plant extracts and/or pharmaceuticals. However, few data are available on the side effects of several plants included in this review, and more clinical studies with controlled administrations should be conducted to address this issue.

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Section: Discussionmentioning

confidence: 99%

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects

et al. 2020

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“…Siegloch et al (2012) also reported septate fibers with bordered pits in Croton dracunculoides and Croton pycnocephalus, but these features were not found in C. piptocalyx. In Croton echioides, Novello et al (2012) observed mostly solitary vessels, as well as multiple pairs and clusters, gelatinous fibers, and uniseriate rays, which are all distinct features of C. piptocalyx.…”

Section: Macro and Microscopic Anatomical Description Of Croton Piptomentioning

confidence: 92%

“…The wood of some species of this genus have already been studied (Luchi, 2004;Wiedenhoeft, 2008;Wiedenhoeft et al, 2009;Longui et al, 2012;Novello et al, 2012;Siegloch et al, 2012). However, no studies in the literature have reported on C. piptocalyx wood.…”

Section: Introductionmentioning

confidence: 99%

WOOD AXIAL CHARACTERIZATION OF 32-YEAR-OLD Croton piptocalyx Müll. Arg. EUPHORBIACEAE

Assad¹,

Longui²,

Flörsheim³

et al. 2016

Rev. Inst. Florest.

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This paper aims to characterize the wood anatomy of Croton piptocalyx. To carry out an investigation of axial variation, discussing it in a functional context, helping to increase knowledge about the species. Five randomly selected 32-year-old trees were felled at the Luiz Antonio Experimental Station, located in Luiz Antonio City, São Paulo state, Brazil. From stems, discs were cut from six different stem heights (stem base, 1 m, 2 m, 3 m, 4 m, and 5 m). For each disc, samples close to the bark were removed for wood anatomy studies and specific gravity calculation. Wood anatomy of C. piptocalyx generally agrees with that of other species of the genus as described in the literature. However, variation in both quantitative and qualitative data could be related to tree age and species differences. Axial variations found in vessel element length, vessel diameter and ray height can be respectively related to the hypothesized Typical Radial Pattern based on the occurrence of shorter and narrower cells in younger parts of the wood, involving vessel element length and diameter, and mechanical requirement in the case of higher rays at the trunk base.

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“…In addition, plants of this genus have been studied for their anti-cancer action. The extract of C. campestris had its antitumor activity confirmed, inhibiting the growth of lung tumor cells (Monteiro, 2012), and some indole alkaloids of C. echioides showed in vitro action to combat human colon carcinoma (Mello et al, 2010 andNovello et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity of extracts and compounds isolated from Croton echioides in animal tumor cell (HTC)

et al. 2022

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The search for compounds with anticancer effects is of paramount importance today due to the high incidence of the disease. The Euphorbiaceae family is known for having compounds with therapeutic properties, one of its genera being Croton. It has several species, which contain compounds already known for their biological activities, presenting anti-inflammatory, antimicrobial and anticancer properties. Thus, the cytotoxicity/antiproliferative activity of semi-purified fractions and compounds isolated from Croton echioides in liver tumor cells of Rattus norvegicus (HTC) was evaluated by the MTT test. The semi-purified fractions showed cytotoxicity at concentrations above 200 µg/mL, at 24, 48 and 72 hours, reaching cell viability of 24.78% [400 µg/mL] at 24 hours, 12.79% [500 µg/mL] at 48 hours and 10.57% [300 µg/mL] at 72 hours. For the isolated compounds, lupeol had a cytotoxic effect in all concentrations (1, 5, 10, 15, 20, 40, 60, 80 and 100 µg/mL) and tested times (24, 48 and 72 hours), reaching minimum viability of 4.37% [100 µg/mL], within 72 hours. The clerodan diterpenes CEH-1 and CEH-4 also showed antiproliferative activity, with minimum viability of 36.19% [100 µg/mL] over 72 hours and 21.33% [100 µg/mL] over 48 hours, respectively. However, the clerodan diterpenes CEH-2 and CEH-3 did not shows a cytotoxic effect for HTC cells. Thus, there is a cytotoxic/antiproliferative potential of C. echioides against tumor cells, with targeted to mitochondrial enzymes, associated with cell proliferation, indicating that this species deserves prominence in the search for new molecules for the treatment of cancer.

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Morphoanatomy and pharmacognostic study of the wood of Croton echioides, the Northeastern Marapuama

Abstract: Croton echioides Baill., Euphorbiaceae, is a small tree found in Bahia, Northeastern Brazil.

Cited by 6 publications

References 25 publications

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects

Pharmacology of Herbal Sexual Enhancers: A Review of Psychiatric and Neurological Adverse Effects

WOOD AXIAL CHARACTERIZATION OF 32-YEAR-OLD Croton piptocalyx Müll. Arg. EUPHORBIACEAE

Cytotoxicity of extracts and compounds isolated from Croton echioides in animal tumor cell (HTC)

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