2011
DOI: 10.1590/s0102-695x2011005000137
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Abstract: Abstract:The antispasmodic effects of acqueous extracts (AE) and tinctures (T) of Aloysia polystachya (Griseb.) Moldenke and Aloysia gratissima (Gillies & Hook.) Tronc., Verbenaceae, were studied on rat isolated ileum and duodenum. These plants are used for gastrointestinal disorders and as eupeptic in South America. Both AE non-competitively inhibited the dose-response curves (DRC) of ACh and the DRC of Ca 2+ in high-[K + ] o , as well as the T. The T of A. polystachya and A. gratissima respectively inhibited… Show more

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Cited by 20 publications
(12 citation statements)
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“…Pre-incubation of aortic segments with eugenol, linalool or carvone could effectively reduce PE-induced contraction. Similar relaxant actions by these active compounds have been shown by others investigators in various smooth muscle tissues (11, 12, 15). Eugenol has been reported to inhibit PE-induced contraction by the same magnitude in both the absence and presence of apocynin, suggesting that it acts by inhibiting ROS (13).…”
Section: Discussionsupporting
confidence: 87%
See 1 more Smart Citation
“…Pre-incubation of aortic segments with eugenol, linalool or carvone could effectively reduce PE-induced contraction. Similar relaxant actions by these active compounds have been shown by others investigators in various smooth muscle tissues (11, 12, 15). Eugenol has been reported to inhibit PE-induced contraction by the same magnitude in both the absence and presence of apocynin, suggesting that it acts by inhibiting ROS (13).…”
Section: Discussionsupporting
confidence: 87%
“…These active principles are reported to show relaxation effect on the cardiovascular system (10-12). The relaxant effects of eugenol and linalool on both the aorta and trachea has been shown in our previous work (13, 14).…”
Section: Introductionmentioning
confidence: 99%
“…Since tincture and essential oil were a mix of compounds, the affinity (pK B´) could not be calculated (Kenakin, 2014). The 50% inhibitory concentration (IC 50 ) was calculated by interpolation at 50% effect of the individual inhibitory curves, that is, those obtained for each biological preparation by plotting the maximal agonist effects in the absence and the presence of the subsequent concentrations of the antagonist (T-Bs, EO-Bs or 1,8-cineole), as previously described (Consolini et al 2011;Matera et al 2012). IC 50 values of EO-Bs or 1,8-cineole were expressed as µg/mL after considering the respective density of the natural product.…”
Section: Pharmacological Parameters Of Crcmentioning
confidence: 99%
“…Within this context, we cite several monoterpenes with different applications, especially in the pharmaceutical industry, food and cosmetics. Many of them have different biological properties, such as antifungal, antioxidant, anticancer, anti-spasmodic and larvicidal activities [5][6][7][8][9]. It was also denoted antinociceptive and antiinflammatory activities, especially on glutamatergic neurotransmission [10].…”
Section: Introductionmentioning
confidence: 99%