Acute and sub-acute toxicity studies of Passiflora nepalensis in rats

Patel, Sita Sharan; Verma, Shashi Kant; Nayak, Govind; Singhai, Akhlesh Kumar; Ganesh, N.

doi:10.1590/s0102-695x2011005000103

Cited by 6 publications

(3 citation statements)

References 22 publications

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“…Histopathological investigation of the vital organs was done. The organs include stomach, heart, kidneys, liver, and spleen of the animals were preserved they were subjected to histopathological examination [14].…”

Section: Histopathologymentioning

confidence: 99%

Acute and Subacute Toxicity Studies of Ethanolic Extract of Mirabilis Jalapa Linn in Wistar Albino Rats

Kesavelu

2021

Asian J Pharm Clin Res

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Objective: The objective of the study was to evaluate the toxicological potential of the ethanolic extract of leaves of Mirabilis jalapa linn through acute and subacute toxicity studies in albino Wistar rats. Methods: For acute toxicity studies, the ethanolic extract of M. jalapa was given up to 2000 mg/kg and then the animals were observed for 14 days to find out any adverse effect or death. For sub-acute toxicity studies, the exact was given for 28 days and the following parameters were observed such as changes in body weight, food intake, water intake, hematological parameters, biochemical parameters, lipid profile, urine analysis, and histopathological studies were undertaken. Results: Single oral administration of 2000 mg/kg of the ethanolic extract of M. jalapa produced no mortality or signs of toxicity. During subacute toxicity there were no changes in body weight, food intake and water intake were observed. There were no changes in lipid profile, hematological parameters, and biochemical parameters. In histopathological changes, there were no structural changes in treated groups when compared to control. Conclusion: The leaves of ethanolic extract of M. jalapa is safe when administered for 28 days. There were no deaths or signs of toxicity in treated rats during acute toxicity studies and subacute toxicity studies.

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Section: Histopathologymentioning

confidence: 99%

Acute and Subacute Toxicity Studies of Ethanolic Extract of Mirabilis Jalapa Linn in Wistar Albino Rats

Kesavelu

2021

Asian J Pharm Clin Res

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“…Biochemical parameters are also important because they allow for the evaluation of all organs and the general condition of the animal body, especially regarding renal and hepatic functions [19]. In acute toxicity, parameters of biochemical analysis showed no significant differences in relation to the control group.…”

Section: Controlmentioning

confidence: 99%

Acute and Subacute Toxicological Studies of Annona Vepretorum in Experimental Animals

Silva

Diniz

Lavor

et al. 2019

PMIO

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Annona vepretorum is endemic from the Brazilian Caatinga biome and is used in human nutrition. The present study aimed to investigate the toxic effects of the ethanolic extract from the leaves of this species. The leaves of A. vepretorum were collected, dried, pulverized, and macerated with ethanol to yield the crude ethanol extract of A. vepretorum. HPLC-diode array detection was used to determine the fingerprint chromatogram of the extract. In toxicity studies, the acute toxicity experimental group was administered a single dose of the ethanol extract of A. vepretorum (1 g/kg), while in the subacute toxicity experimental group, the ethanol extract of A. vepretorum was administered orally, daily for 30 days, at doses of 100 and 400 mg/kg. Death and signs of toxicity were observed and at the end, the animals were anesthetized, and blood and organs were then collected. The presence of the flavonoid rutin in the extract was confirmed using HPLC-diode array detection. In the evaluation of acute and subacute toxicity, there were no behavioral and physiological changes or signs of toxicity, and no occurrences of mice deaths were registered. The organs had normal color and preserved architecture, and no statistical variations in weight were observed. The results of the hematological and biochemical parameters after the administration of the ethanol extract of A. vepretorum showed no significant change, except in the count of the number of leukocytes and triglycerides. The histopathologic analysis of the liver, kidneys, and stomach indicated architecture with normal aspects. Thus, the toxicity study indicates low toxicity of the ethanol extract of A. vepretorum. Such information will be helpful in future clinical studies.

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“…The antioxidative effect of phytotherapeutic principles inherent in medicinal plants have been exhaustively researched and reported (Patel et al, 2011;Afagnigni et al, 2017;Akindele et al, 2018;Kale et al, 2019;Shehu and Yabagi, 2019). The pro-oxidant action of phenoxyl radicals generated from the electron-donating action of phenolic compounds has been strongly implicated in inducing oxidative stress (Sakihama et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Effects of Aqueous Leaf Extract of Simarouba glauca DC (Simaroubaceae) on Lipoprotein Homeostasis and Oxidative Stress Biomarkers

Osagie-Eweka

Orhue

Omogbai³

2021

Pharmacol Toxicol Nat Med

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Background and Purpose: Simarouba glauca is widely reported to contain a number of biologically active compounds with potentials in the treatment of numerous diseases. The study was conducted to evaluate the sub-acute effects of the aqueous leaf extract of Simarouba glauca (AESG) on lipoproteins and oxidative stress biomarkers in male Wistar rats. Methods: Oral administration of AESG was carried out in line with the guidelines of the Organization for Economic Co-operation and Development (OECD), No. 425 using a total of 24 male Wistar rats allotted to four groups (n=6); given distilled water, 500, 1000, and 2000 mg/kg/day of AESG respectively for 30 days. Results: In plasma, there was a significant reduction (P?0.05) in HDL-cholesterol; elevated (P?0.05) triglycerides (TG) at 1000 and 2000 mg/kg/day; elevated (P?0.05), and LDL-cholesterol at 500 and 1000 mg/kg/day, relative to the control. While the level of liver total cholesterol (TC) reduced significantly, it increased in the heart. Catalase (CAT) activity in the liver increased significantly (P?0.05) at all doses. The dose of 1000 mg/kg/day significantly (P?0.05) elevated kidney CAT activity. The activities of superoxide dismutase (SOD) in liver and heart reduced (P?0.05) at 500 mg/kg/day. At all doses, the levels of reduced glutathione (GSH) in plasma, liver and heart were comparable with the control. Although, there were no significant changes in plasma and liver glutathione peroxidase (GSH-PX) activity at all doses, animals given 500 mg/kg had reduction (P?0.05) in the heart GSH-PX activity compared to the control. Conclusion: Oral sub-acute AESG at high doses altered lipid homeostasis in plasma and heart without lipid peroxidation or oxidative stress. The extract has the potential to cause hyperlipidemia.

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Acute and sub-acute toxicity studies of Passiflora nepalensis in rats

Cited by 6 publications

References 22 publications

Acute and Subacute Toxicity Studies of Ethanolic Extract of Mirabilis Jalapa Linn in Wistar Albino Rats

Acute and Subacute Toxicity Studies of Ethanolic Extract of Mirabilis Jalapa Linn in Wistar Albino Rats

Acute and Subacute Toxicological Studies of Annona Vepretorum in Experimental Animals

Effects of Aqueous Leaf Extract of Simarouba glauca DC (Simaroubaceae) on Lipoprotein Homeostasis and Oxidative Stress Biomarkers

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