Antioxidant activity of natural compounds of Stachytarpheta cayennensis (Rich.) Vahl, Verbenaceae, by scavenger of mitochondrial reactive oxygen species

Abstract

Abstract:The etiology of a range of diseases is associated with an excessive generation of reactive oxygen species (ROS). Exacerbated ROS production leads to mitochondrial dysfunction, cellular damage and apoptosis. Nowadays, many strategies are being developed for the targeted delivery of antioxidants compounds to mitochondria, trying to minimize the damages. Production of ROS was investigated by the molecular probes CM-H 2 DCFDA and Amplex Red. The purpose of this work is to evaluate the antioxidant capacity of verbascoside, martinoside, betulinic acid from the Stachytarpheta cayennensis and quercetin by an in vitro assay with isolated mitochondria from mice's brain The results showed that all compounds tested exhibited a scavenger effect on the ROS generated by the isolated mitochondria, which displayed a dependent dose increase.

Chemical and Pharmacological Investigation of the Stem Bark of Synadenium grantii

“…Antonisamy et al presented a study with a pentacyclic triterpene isolated from Azimate tracantha (Salvadoraceae) that demonstrated an anti-inflammatory, analgesic, and antipyretic effect in mouse and rat models [3]. Montanha et al demonstrated this effect from the Loranthus regularis (Loranthaceae) extract and identified the phenolic constituents in this material [15], while Magalhães et al and Souza et al described antioxidant properties from Maytenus salicifolia (Celastraceae) and Stachytarpheta cayennensis (Verbenaceae) extracts [13,14].…”

“…Likewise, compounds such as proteases [11] and lectin were found to have hemagglutination inhibition [12]. The literature states that terpenes and phenolic compounds are commonly found in the genus Synadenium [8,9] and that these compounds present free radical inhibition and anti-inflammatory activities [3,13,14]. The aim of this work was to evaluate the antioxidant and anti-inflammatory activities as well as to perform a phytochemical investigation of the stem bark of S. grantii in order to identify the compounds responsible for its ethnopharmacological indications.…”

Hepatoprotective potential of Tecomella undulata stem bark is partially due to the presence of betulinic acid

“…However, pre-treatment of TBS-7 or MS-2 significantly minimised CCl 4 induced depletion of antioxidant and prevented lipid peroxidation. These results are attributable to the significant antioxidant and free radical scavenging potential of TBS-7 and MS-2 (de Souza et al, 2011;Zheng et al, 2011).…”

Natural compounds against doxorubicin‐induced cardiotoxicity: A review on the involvement of Nrf2/ARE signaling pathway

“…NCs have various beneficial effects on human health (Lobo, Patil, Phatak, & Chandra, 2010). They play important roles as ROS scavenger (Rezaee et al, 2013(Rezaee et al, , 2014Souza et al, 2011), and exert antioxidative (Kim, Kim, Kim, & Heo, 1997), and anti-inflammatory (Dvořák, Vrzal, Maurel, & Ulrichová, 2006) activities in various tissues.…”