Preliminary study of the molluscicidal and larvicidal properties of some essential oils and phytochemicals from medicinal plants

Leite, Aristides Medeiros; Lima, Edeltrudes de O.; Souza, Evandro Leite de; Diniz, Margareth de Fátima Formiga Melo; Leite, Sônia Pereira; Xavier, Aline Lira; Medeiros, Isac A.

doi:10.1590/s0102-695x2009000600008

Cited by 24 publications

(20 citation statements)

References 28 publications

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“…Rabêlo (2010) also evaluated the toxicity of eugenol and found a value of LC 50 of 18.53 µg.mL -1 , and associated the higher toxicity of oil to the possibly synergic effect among the other compounds of the essential oil. Leite et al (2009) found higher values of LC 50 for eugenol (47.6 µg.mL -1 ).…”

Section: Determination Of Toxicity Against Artemia Salinamentioning

confidence: 76%

“…It has been shown that there is a very good correlation between the median lethal concentrations (LC 50 ) of plant extracts to brine shrimp larvae and the median lethal doses (LD 50 ) of the same extracts, administered orally in mice (Parra et al, 2001). Besides, the essential oils with high toxic potential have been target of investigation to the production of insecticides, related to control of larvae of vectors of diseases related to public health (Leite et al, 2009). Despite described properties of eugenol and eugenyl acetate, there is a lack in the literature regarding the eugenyl acetate toxicity in A. salina.…”

Section: Introductionmentioning

confidence: 99%

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Toxicity of clove essential oil and its ester eugenyl acetate against Artemia salina

et al. 2017

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The production of compounds via enzymatic esterification has great scientific and technological interest due to the several inconveniences related to acid catalysis, mainly by these systems do not fit to the concept of "green chemistry". Besides, natural products as clove oil present compounds with excellent biological potential. Bioactives compounds are often toxic at high doses. The evaluation of lethality in a less complex animal organism can be used to a monitoring simple and rapid, helping the identification of compounds with potential insecticide activity against larvae of insect vector of diseases. In this sense, the toxicity against Artemia salina of clove essential oil and its derivative eugenyl acetate obtained by enzymatic esterification using Novozym 435 as biocatalyst was evaluated. The conversion of eugenyl acetate synthesis was 95.6%. The results about the evaluation of toxicity against the microcrustacean Artemia salina demonstrated that both oil (LC 50 = 0.5993 µg.mL -1 ) and ester (LC 50 = 0.1178 µg.mL -1 ) presented high toxic potential, being the eugenyl acetate almost 5 times more toxic than clove essential oil. The results reported here shows the potential of employing clove oil and eugenyl acetate in insecticide formulations.Keywords: Novozym 435, Caryophyllus aromaticus, enzymatic esterification.Toxicidade do óleo essencial de cravo e seu éster acetato de eugenila contra Artemia salina ResumoA produção de compostos via esterificação enzimática possui grande interesse científico e tecnológico devido às inúmeras inconveniências relacionadas com a catálise ácida, principalmente por estes sitemas não se adequarem ao atual termo "tecnologias limpas". Além disso, produtos naturais como o óleo de cravo, apresentam compostos com excelentes potenciais biológicos. Compostos bioativos são quase sempre tóxicos em altas doses. A avaliação da letalidade em um organismo animal menos complexo pode ser usada para um monitoramento simples e rápido, servindo também para a identificação de compostos com potencial atividade inseticida contra larvas de insetos vetores de doenças. Neste sentido, foi determinada a toxicidade frente a Artemia salina do óleo essencial de cravo e do seu derivado acetato de eugenila obtido por esterificação enzimática com lipase Novozym 435. A conversão da reação de síntese de acetato de eugenila foi de 95,6%. Os resultados referentes à avaliação da toxicidade frente ao microcrustáceo Artemia salina demonstraram que tanto o óleo (LC 50 = 0,5993 µg.mL -1 ) quanto o éster (LC 50 = 0,1178 µg.mL -1 ) apresentam elevado potencial toxicológico, sendo que o éster apresenta aproximadamente 5 vezes mais toxicidade em relação ao óleo. Estes resultados demonstram o potencial emprego do óleo de cravo e de acetato de eugenila em formulações de inseticidas.Palavras-chave: Novozym 435, Caryophyllus aromaticus, esterificação enzimática.

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Section: Determination Of Toxicity Against Artemia Salinamentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Toxicity of clove essential oil and its ester eugenyl acetate against Artemia salina

et al. 2017

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“…Essential oils have been largely used against several diseases, occasionally based on folk medicine observations (Daniel et al, 2009;Leite et al, 2009). Thus, approximately 300 characterized essential oils are economically important because of their extensive use in the pharmaceutical, cosmetic, and perfume industries (Bakkali et al, 2008).…”

Section: Resultsmentioning

confidence: 99%

Chemical composition and antimicrobial activity of Hedyosmum brasiliense Miq., Chloranthaceae, essential oil

Kirchner

Wisniewski

Cruz

et al. 2010

Rev. bras. farmacogn.

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RESUMO:Óleo essencial de Hedyosmum brasiliense Miq., Chloranthaceae: composição e atividade antimicrobiana. Hedyosmum brasiliense Miq., Chloranthaceae, é uma espécie endêmica no Brasil, conhecida como "cidrão". Embora H. brasiliense seja utilizada como calmante na medicina popular, não foi ainda caracterizada quanto aos constituintes químicos. Este trabalho apresenta a composição do óleo essencial, obtido pela destilação de folhas frescas e de amostra de óleo essencial armazenada por três meses, analisadas por GC-FID e CG-MS. Os efeitos inibitórios do óleo essencial foram testados pelo método da diluição em agar, contra seis espécies de bactérias (Bacillus subtilis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus e S. saprophyticus). Adicionalmente, seis espécies de fungos (Candida albicans, C. parapsilosis, Microsporum canis, M. gypseum, Trichophyton rubrum e T. mentagrophytes) foram incluídas. Dentre os principais constituintes, α-terpineol (10,2%), curzereno (8,9%), pinocarvona (8,4%) e β-tujeno (7,1%) foram os encontrados em maior quantidade. O óleo essencial apresentou baixa atividade contra microorganismos Gram-negativos. Entretanto, a atividade é extraordinária contra bactérias Gram-positivas e fungos, com valores de MIC entre 0,125 a 2,5% (v/v). Unitermos:Hedyosmum brasiliense, Chloranthaceae, óleo essencial, atividade antimicrobiana. ABSTRACT:Hedyosmum brasiliense Miq., Chloranthaceae, is an endemic species of Brazil, locally known as "cidrão". Although H. brasiliense is popularly used as sedative, chemical constituents of this species remains uncharacterized. This work presents the essential oil composition, obtained by the distillation of fresh leaves and a sample stored for three months, analysed by GC-FID and GC-MS. The inhibitory effects of the essential oil were tested by the agar dilution method against six bacterial species (Bacillus subtilis, Escherichia coli, Proteus mirabilis, Pseudomonas aeruginosa, Staphylococcus aureus and S. saprophyticus). In addition, six fungal species (Candida albicans, C. parapsilosis, Microsporum canis, M. gypseum, Trichophyton rubrum and T. mentagrophytes) were included. Among the determined constituents, α-terpineol (10.2%), curzerene (8.9%), pinocarvone (8.4%) and β-thujene (7.1%) were found as the main components. The essential oil has low activity only against Gram-negative microorganisms. However, it is a remarkable active against Grampositive bacteria and fungi with MIC values ranging from 0.125 to 2.5% (v/v).

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“…A tea made from the leaves has been used in folk medicine to lower fever and blood pressure and to combat infections (Consolini et al, 1999). There are also reports of strong antibacterial, cytotoxic, molluscicidal, larvicidal and antifungal activities of E. unifl ora L. against pathogenic agents (Lima et al, 1993;Holetz et al, 2002;Souza et al, 2004;Ogunwande et al, 2005;Leite et al, 2009;Costa et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

A new approach for quantifying furanodiene and curzerene: a case study on the essential oils of Eugenia uniflora L., Myrtaceae (pitangueira) leaves

Chang¹,

Morais²,

Napolitano³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The essential oil obtained from the leaves of Eugenia uniflora L., Myrtaceae, which grows in the Brazilian savannah, was studied by gas chromatography mass spectrometry (GC-MS). Furanodiene (1.2%) was thermally rearranged to curzerene (85.1%) to produce a combined content of 86.3%. GC analysis carried out under mild conditions (with a constant temperature of 100 o C) showed that the furanodiene concentration was threefold greater than the curzerene concentration, i.e., the essential oil contained 64.7% furanodiene and 21.6% curzerene. Germacrene B also rearranged to γ-elemene and the concentration of both was 2.3%. Special care should be taken when conventional gas chromatography analysis is used for quantifying compounds that can rearrange at high temperatures.

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Preliminary study of the molluscicidal and larvicidal properties of some essential oils and phytochemicals from medicinal plants

Cited by 24 publications

References 28 publications

Toxicity of clove essential oil and its ester eugenyl acetate against Artemia salina

Toxicity of clove essential oil and its ester eugenyl acetate against Artemia salina

Chemical composition and antimicrobial activity of Hedyosmum brasiliense Miq., Chloranthaceae, essential oil

A new approach for quantifying furanodiene and curzerene: a case study on the essential oils of Eugenia uniflora L., Myrtaceae (pitangueira) leaves

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