Assessment of anti-hyperlipidemic effect of Citrullus colocynthis

Zamani, Marzyieh; Rahimi, Alireza; Mahdavi, Reza; Nikbakhsh, Mohammed; Jabbari, Masoumeh; Rezazadeh, Hassan; Delazar, Abbas; Nahar, Lutfun; Sarker, Satyajit D.

doi:10.1590/s0102-695x2007000400003

Cited by 21 publications

(10 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The major biochemical effect of CCAE was to lower serum TG levels in both diabetic models. TG levels rose in the sera of diabetic rats in agreement some reports [26,27]; then signi cantly decreased towards normal in the treated groups (CCAE-NIA/STZ and CCAE-STZ groups vs. NIA/STZ and STZ groups: p = 0.0006 and p=0.0335, respectively) consistent with other reports [28][29][30][31][32]. Oral administration of 70% alcohol extract of the pulp (1.2 g/kg) in atherogenic rabbits was reported to signi cantly lower total cholesterol, triglycerides, and phospholipids in their liver, heart, and serum [33].…”

Section: Blood Biochemistrysupporting

confidence: 91%

Differential Expression of Gluconeogenic Enzymes in Early- and Late- Stage Diabetes: The Effect of Citrullus Colocynthis Seed Extract on Hyperglycemia and Hyperlipidemia

Afshari¹,

Salimi²,

Babaie³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The extent of metabolic disruption and the usefulness of drugs and supplements, such as medicinal plants, in patients with diabetes may be impacted by the severity of the disease. Method: Nicotinamide + STZ together and STZ alone were used to induce early- and late-stage diabetes type 2 (ET2D and LT2D, respectively) in rats. Glucose tolerance test (GTT) was performed because the stage of disease was considered compatible with the magnitude of deviation from normal glucose tolerance test (GTT), as well as the level of FBS. Three main groups of the study were nondiabetic, early-stage diabetic, and late-stage diabetic rats. Each group was divided into two sub-groups, one of which received Citrullus colocynthis seed aqueous extract (CCAE, 90mg/kg BW) for 28 days. Weekly FBS and body weights were recorded during the study. At the end of 28 days, the serum levels of ALT, AST, ALP, TG, urea, creatinine, uric acid, cholesterol, HDL, LDL, c-peptide, and HbA1c were measured; the hepatic mRNA expression of several enzymes of glucose and fat metabolic pathways were also determined by Real-Time PCR. The accumulation of fat in the hepatic tissue was visualized by measuring the TG content and by H&E and Oil-Red staining and the degree of oxidative stress was measured by protein carbonyl content (PCC).Results: The LT2D rats showed maximal deviations from normal GTT. GTT for control and ET2D rats were similar, yet the area under curve (AUC) for ET2D rats was significantly higher. Urea, ALT, and ALP levels were high in diabetic rats compared to control and significantly different from each other.Serum TG dropped and ALT, ALP, HDL and LDL significantly improved after treatment with CCAE. Different patterns of G6Pase and PEPCK expression in ET2D and LT2D suggested their similarity to short- and long-term fasting states, respectively. While the reduction of FBS levels in ET2D could be explained by an inhibition of G6Pase expression and therefore glycogenolysis, the level of PEPCK expression was not significantly lowered by CCAE in LT2D. H&E staining of liver tissue showed steatoses of varying morphology in both ET2D and LT2D rats. CCAE led to up-regulated PPARα and down-regulated CPT1 expressions.Conclusion: As PEPCK activity is necessary for the continuation of the TG/FA cycle during fasting, it is possible that in LT2D, CCAE directed the PEPCK activity more towards glyceroneogenesis than gluconeogenesis to ensure the persistence of the TG/FA cycle. The enhanced glyceroneogenesis together with an up-regulated PPARa expression and down-regulated CPT1 expression probably led to lower blood and hepatic TG. More research is needed to establish the effect of CCAE on PEPCK expression and its course of activity.

show abstract

Section: Blood Biochemistrysupporting

confidence: 91%

Differential Expression of Gluconeogenic Enzymes in Early- and Late- Stage Diabetes: The Effect of Citrullus Colocynthis Seed Extract on Hyperglycemia and Hyperlipidemia

Afshari¹,

Salimi²,

Babaie³

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…The reduction of LDL-C in the groups receiving the pulp extracts and 100 mg/kg seed extract were significant (p<0.05). The impact of C. colocynthis on the blood lipid profile in rabbits might be because of high measures of saponins in C. colocynthis which diminished cholesterol levels by lessening the ingestion of cholesterol, expanding the repulse of feces estriol and looseness of the bowels because of expanded peristalsis [19].…”

Section: Antihyperlipidemic Effectmentioning

confidence: 99%

A Review on Phytochemical Studies and Biological Potential of Citrullus colocynthis (L.) Schrad. (Cucurbitaceae)

Dhakad¹,

Sharma²,

Kumar³

2017

View full text Add to dashboard Cite

Cucurbits are edible crops found in the Cucurbitaceae family. Interest in plant-based biological compounds has now awakened throughout the world and hence the literature data in this area is significant. The Cucurbitaceae family is distributed in the tropical and subtropical countries. The plants of this family are superb fruit crops rich in vitamins, nutrients, and minerals that very good for health. A number of plants belonging to this family have been reported so far and one among them is Citrullus colocynthis (L.) Schrad. All the parts of this plant (root, stem, leaf, fruits, and seeds) are utilized in the traditional system of medicine. A plethora of research is going on this plant species to discover new active moiety and to establish their medicinal importance. The present review gives updated information about the phytochemistry and pharmacological activities of Citrullus colocynthis (L.) Schrad. established so far. As per the research so far among different cucurbitacins, cucurbitacin E is known to be found profoundly in Citrullus colocynthis (L.) Schrad. Some of the biological activities reported for this plant include antioxidant activity, antimicrobial activity, anti-diabetic activity, anti-hyperlipidemic activity, analgesic activity, anti-ulcer activity, anticonvulsant activity and insecticidal activity.

show abstract

“…Previous phytochemical studies on E. agallocha revealed the presence of diterpenoids (ISI database, 2008;Ji-Dong et al, 2007;Li et al, 2007;Wang et al, 2006Kang et al, 2005), triterpenoids (Zou et al, 2006), fl avonoid (Konishi et al, 2003) and phorbole esters (Ericson et al, 1995). As part of our continuing phytochemical and bioactivity studies on Bangladeshi medicinal plants and also in other parts of the world (Alam et al, 2008a,b;Ali et al, 2008;Datta et al, 2007Datta et al, , 2004Saha et al, 2007;Uddin et al, 2007aUddin et al, -c, 2006aUddin et al, ,b, 2005Uddin et al, , 2004Rouf et al, 2006;Haque et al, 2004;Rahman et al, 2004;Delazar et al, 2006;Shoeb et al, 2007;Auzi et al, 2007;Zamani et al, 2007;Razavi et al, 2008), we now report on the neuropharmacological and antibacterial activities, and acute toxicty of the ethanol extract of the bark of E. agallocha in laboratory rodents as well as brine shrimp toxicity.…”

Section: Introductionmentioning

confidence: 99%