Trans-Aconitic acid, glucosylflavones and hydroxycinnamoyltartaric acids from the leaves of Echinodorus grandiflorus ssp. aureus, a Brazilian medicinal plant

Schnitzler, Miriam; Petereit, Frank; Nahrstedt, Adolf

doi:10.1590/s0102-695x2007000200002

Cited by 26 publications

(12 citation statements)

References 19 publications

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“…(2-O-caffeoyl-(2R,3R)-(+)-tartaric acid) was isolated from Echinodorus grandiflorus ssp. aureus (Alismataceae) (Schnitzler, Petereit, & Nahrstedt, 2007).…”

Section: Chemicalsmentioning

confidence: 99%

Fast determination of N-phenylpropenoyl-l-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis

et al. 2012

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“…(2-O-caffeoyl-(2R,3R)-(+)-tartaric acid) was isolated from Echinodorus grandiflorus ssp. aureus (Alismataceae) (Schnitzler, Petereit, & Nahrstedt, 2007).…”

Section: Chemicalsmentioning

confidence: 99%

Fast determination of N-phenylpropenoyl-l-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis

et al. 2012

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“…Phytochemical evaluation of extracts made from leaves has led to the identification of cembrane and clerodane-type diterpenoids, sesquiterpenes and flavonoids (Schnitzler et al 2007, Costa et al 1999, Tanaka et al 1997, Manns and Hartmann 1993). Maillard's products, those originated from the reaction between aminoacids and reducing sugars upon heating, are well known mutagenic compounds and their formation in food products is kept to a minimum to prevent loss of quality and nutritional properties (Powrie et al 1986).…”

Section: Introductionmentioning

confidence: 99%

Genotoxic Maillard byproducts in current phytopharmaceutical preparations of Echinodorus grandiflorus

Lima

Waldhelm

Alves

et al. 2014

An. Acad. Bras. Ciênc.

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Extracts of Echinodorus grandiflorus obtained from dried leaves by three different techniques were evaluated by bacterial lysogenic induction assay (Inductest) in relation to their genotoxic properties. Before being added to test cultures, extracts were sterilized either by steam sterilization or ultraviolet light. Only the extracts prepared by infusion and steam sterilized have shown genotoxic activity. The phytochemical analysis revealed the presence of the flavonoids isovitexin, isoorientin, swertisin and swertiajaponin, isolated from a genotoxic fraction. They were assayed separately and tested negative in the Inductest protocol. The development of browning color and sweet smell in extracts submitted to heat, prompted further chemical analysis in search for Maillard´s reaction precursors. Several aminoacids and reducing sugars were cast in the extract. The presence of characteristic Maillard´s melanoidins products was determined by spectrophotometry in the visible region and the inhibition of this reaction was observed when its characteristic inhibitor, sodium bisulfite, was added prior to heating. Remarkably, this is the first paper reporting on the appearance of such compounds in a phytomedicine preparation under a current phytopharmaceutical procedure. The genotoxic activity of such heat-prepared infusions imply in some risk of developing degenerative diseases for patients in long-term, uncontrolled use of such phytomedicines.

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“…A composição química de folhas das espécies de Echinodorus avaliada até o presente sugere um conteúdo químico constituído por ácido trans-aconítico, glicosilflavonas e ácido hidroxitartárico (Schnitzler et al, 2007), sesquiterpenos (Pimenta et al, 2006) e, principalmente, diterpenos dos tipos clerodano, cembrano e labdano (Manns & Hartmann, 1993;Tanaka et al, 1997;Costa et al, 1999;Kobayashi et al, 2000a;b), substâncias estas presentes nos extratos avaliados e que, provavelmente, estão envolvidas nas atividades biológicas relatadas até o momento, tais como atividade anti-hipertensiva (Lessa et al, 2008), imunossupressora (Pinto et al, 2007), vasodilatadora (Tibiriçá et al, 2007), hipocolesterolemiante (Cardoso et al, 2005), antimicrobiana (Coelho de Souza et al, 2004), diurética (Ribeiro et al, 1988;Cardoso et al, 2003) e analgésica e antiinflamátoria (Cardoso et al, 2003;Dutra et al, 2006). No entanto, Garcia et al (2010) demonstraram que a fração contendo derivados do ácido tartárico não possui atividade antiedematogênica.…”

Section: Introductionunclassified

Validação de metodologia analítica para a determinação de derivados do ácido o-hidroxicinâmico de Echinodorus grandiflorus

Lopes¹,

Santos²,

Diciaula³

et al. 2012

Rev. bras. plantas med.

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RESUMO:Este artigo descreve o desenvolvimento e a validação de método espectrofotométrico UV-Visível para quantificação de derivados do ácido o-hidroxicinâmico em folhas de Echinodorus grandiflorus. O método demonstrou ser linear (r 2 = 0,9974), preciso (DPR < 15%) na análise de matriz complexa e exata (recuperação = 107,56%). Palavras-chave:Echinodorus grandiflorus, espectrofotometria UV-Vis, derivados do ácido ohidroxicinâmico, controle de qualidade, validação de metodologia analítica ABSTRACT: Validation of analytical methodology for the determination of derivatives of o-hydroxycinnamic acid from Echinodorus grandiflorus. This paper describes the development and the validation of an UV-Vis spectrophotometric method for the quantification of derivatives of o-hydroxycinnamic acid in leaves of Echinodorus grandiflorus. The method showed to be linear (r 2 = 0.9974), precise (RSD < 15%) in the analysis of complex matrix and accurate (recovery = 107.56%).

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Trans-Aconitic acid, glucosylflavones and hydroxycinnamoyltartaric acids from the leaves of Echinodorus grandiflorus ssp. aureus, a Brazilian medicinal plant

Cited by 26 publications

References 19 publications

Fast determination of N-phenylpropenoyl-l-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis

Fast determination of N-phenylpropenoyl-l-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis

Genotoxic Maillard byproducts in current phytopharmaceutical preparations of Echinodorus grandiflorus

Validação de metodologia analítica para a determinação de derivados do ácido o-hidroxicinâmico de Echinodorus grandiflorus

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