Efeito antinociceptivo e antiinflamatório do extrato aquoso da entrecasca de Coutarea hexandra Schum. (Rubiaceae)

Lucena, Josefina Eugenia Xavier de; Bispo, Mágna Lúcia; Nunes, Rogéria de Souza; Cavalcanti, Sócrates Cabral de Holanda; Teixeira-Silva, Flávia; Marçal, R. M.; Antoniolli, Ângelo Roberto

doi:10.1590/s0102-695x2006000100012

Cited by 6 publications

(5 citation statements)

References 15 publications

(20 reference statements)

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“…Thus, Cnidoscolus phyllacanthus, Ricinus communis (Euphorbiaceae) and Coutarea hexandra (Rubiaceae) are chemical compounds whose biological activities have been described [5][6][7][8] .…”

mentioning

confidence: 99%

Bioactivity of plant extracts on the larval and pupal stages of Aedes aegypti (Diptera, Culicidea)

Candido

Cavalcanti

Beserra

2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Aedes aegypti is responsible for the transmission of the dengue and yellow fever viruses. This study evaluated the effects of extracts from Cnidosculos phyllacanthus, Ricinus communis, and Coutarea hexandra on the developmental periods of A.aegypti larvae and pupae. Crude extracts of C. phyllacanthus and C. hexandra and oil from R. communis and C. phyllacanthus were used. Methods: Bioassays of the larvicidal and pupicidal effects of these products at different concentrations and times of exposure were evaluated. The lethal and sublethal effects were determined using different concentrations in larvicidal tests. Mortality data were evaluated by Probit analysis to determine the LC 50 and LC 90 values. Results: The vegetable oils from C. phyllacanthus and R. communis demonstrated greater effi ciency for larval control with an LC 50 =0.28µl/mL and an LC 90 =1.48µl/ mL and LC 50 =0.029µl/mL and a LC 90 =0.26µl/mL, respectively. In pupal tests toxic effects for all insects were verifi ed after exposure to the products at signifi cant LC 50 and LC 90 values for 24 and 48h. The effects of sublethal concentrations of C. phyllacanthus (oil) were more effective on the insects. Conclusions: The vegetables oils from C. phyllacanthus and R. communis demonstrated greater potential from the control of different developmental periods in the life cycle of this insect.

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“…Thus, Cnidoscolus phyllacanthus, Ricinus communis (Euphorbiaceae) and Coutarea hexandra (Rubiaceae) are chemical compounds whose biological activities have been described [5][6][7][8] .…”

mentioning

confidence: 99%

Bioactivity of plant extracts on the larval and pupal stages of Aedes aegypti (Diptera, Culicidea)

Candido

Cavalcanti

Beserra

2013

Rev. Soc. Bras. Med. Trop.

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“…Neste estudo, observou-se sua menção por quilombolas, feirantes (LIMA et al, 2016), benzedeiros, conhecedores de medicinais (MACEDO et al, 2018), como espécie usada para abortos. O efeito mutagênico da espécie foi registrado por Nunes et al (2012) e, juntamente com os ensaios etnofarmacológicos realizados por Lucena et al (2006), confirmaram seus efeitos antiinflamatórios e anticonceptivos. Feirantes citaram essa variedade para o tratamento, também, de amenorreia, sinusite e fortalecimento do sangue (ALVES et al, 2007).…”

Section: Resultsunclassified

O Uso De Plantas Abortivas No Nordeste Brasileiro: Uma Revisão

Nunes

Silva

2021

ethnoscientia

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O uso de plantas para fins abortivos é frequente no Brasil, embora seja prática proibida por lei. O presente trabalho é uma revisão bibliográfica sobre as espécies registradas como abortivas no nordeste brasileiro. Para o desenvolvimento da pesquisa realizou-se um levantamento de artigos sobre o tema e utilizou-se como palavras-chave os seguintes termos: “plantas abortivas”, abortivas, aborto. Foram pesquisados trabalhos sobre etnobotânica, produções que tratavam sobre aborto, bem como o uso de plantas para este fim. Após a seleção dos artigos, dados de 35 trabalhos foram usados nesta revisão. O conhecimento sobre o uso dessas espécies é oriundo de benzedeiros, feirantes, donas de casa, estudantes e gestantes, com idade variando entre 13 e 96 anos. As motivações citadas para a prática do aborto foram: presença de outros filhos, ausência de companheiros, financeiro e questões religiosas, embora as religiões comentadas, evangélica e católica, condenem a prática. De um total de 79 plantas, as mais apontadas foram: Luffa operculata e Coutarea hexandra (citada oito vezes), Aspidosperma pyrifolium (citada seis vezes), Manihot cf. dichotoma e Peumus boldus (citada cinco vezes) e, Anadenanthera colubrina (citada quatro vezes). De modo geral, as mulheres utilizam as plantas sem o entendimento que, embora sejam naturais, apresentam propriedades que podem levar à morte, tanto que algumas usam tais espécies sem o objetivo de abortar, mas para diminuir ansiedade e combater desconfortos digestivos, desconsiderando suas contraindicações de uso. Algumas delas citaram, ainda, a utilização de artifícios na prática de “aborto” sem que estivessem de fato grávidas. Sendo assim, é importante que campanhas sejam realizadas para maior compreensão sobre o uso de plantas medicinais e seus efeitos colaterais, seja para grávidas, seja para a população em geral.

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“…C. hexandra, also popularly known as quina, exhibits diuretic and antipyretic activities, being commonly used to prevent intermittent fever caused by malaria and other infectious diseases [38,39]. Other activities such as anti-inflammatory [28,37], analgesic and antiviral [28] have been identified in C. hexandra. Here, as similarly demonstrated by antivenom therapy, Ch-E administered alone (G5) efficiently prevented the venom-induced increase of serum CK and ALT release (Figure 2), reduced inflammatory responses by decreasing leukocytosis and neutrophilia (Figure 3), including a slight reduction of fibrinogen (Figure 4) after 120 min envenomation (p < 0.05 compared to G3 'venom' for all these parameters, n = 6).…”

Section: Resultsmentioning

confidence: 99%

“…Coutarea hexandra, a Brazilian native plant found in the Atlantic rainforest [27], exhibits a range of therapeutic properties, e.g., suppressive activity on inflammatory responses, anti-nociceptive and anti-cancer actions [28,29], including potent antioxidant activity [30]. Based on these positive aspects associated with the therapeutic functions of C. hexandra, and considering its ability in scavenging efficiently the stable radical 2,2-diphenyl-1picrylhydrazyl [30], we aimed to investigate the counteracting action of C. hexandra aqueous stem bark extract (Ch-E) on the systemic effects induced by L. m. muta venom in rats.…”

Section: Introductionmentioning

confidence: 99%

Counteracting Action of Coutarea hexandra (Rubiaceae) Stem Bark Extract on the Systemic Toxicity Induced by Lachesis muta muta (Viperidae: Crotalinae) Venom in Rats

2021

AJBSR

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Purpose: In this work, we investigated the protective action of Coutarea hexandra aqueous stem bark extract (Ch-E), associated with a commercial antivenom or as a stand-alone therapy, on the acute systemic envenomation induced by Lachesis muta muta in rats.Methods: Male Wistar rats (300-350 g) were exposed to L. m. muta venom (1.5 mg/kg -i.m.) and then treated with a polyvalent antivenom (antivenom:venom ratio 1:3 'v/w' -i.p.), Ch-E (100 mg/kg -i.p.) or combining both of these agents. After 120 min envenomation, animals were anesthetized in order to collect blood samples through intracardiac puncture and, subsequently, euthanized for collecting tissue samples; the hematological-biochemical and histopathological analyses were performed through conventional methods.Results: Venom caused pronounced local oedema, necrosis formation and subcutaneous haemorrhage; Ch-E alone or combined with antivenom prevented the occurrence of subcutaneous haemorrhage. Ch-E administered alone or associated with antivenom effectively prevented the increase of serum creatine kinase (CK) and alanine aminotransferase (ALT) release; Ch-E reduced the release of the serum biomarker (CK-MB) for cardiotoxicity only in association with antivenom. Venom caused pronounced inflammatory responses associated with neutrophilia, eosinophilia and monocytosis; Ch-E alone also contributed significantly to reduce the venom-induced leukocytosis mainly due to its suppressive action on neutrophils. Ch-E prevented the venom-induced increase of reticulocytes either alone or in the presence of antivenom; however, no group had erythrocyte alterations.Ch-E produced effective protection against venom-induced hepatic and renal morphological alterations similarly to antivenom action. Conclusion:Ch-E shows to be an important source of biomolecules with therapeutic potential to prevent efficiently a number of systemic disorders caused by L. m. muta venom in rats, e.g., myotoxicity, hepatotoxicity, inflammatory responses.

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Efeito antinociceptivo e antiinflamatório do extrato aquoso da entrecasca de Coutarea hexandra Schum. (Rubiaceae)

Cited by 6 publications

References 15 publications

Bioactivity of plant extracts on the larval and pupal stages of Aedes aegypti (Diptera, Culicidea)

Bioactivity of plant extracts on the larval and pupal stages of Aedes aegypti (Diptera, Culicidea)

O Uso De Plantas Abortivas No Nordeste Brasileiro: Uma Revisão

Counteracting Action of Coutarea hexandra (Rubiaceae) Stem Bark Extract on the Systemic Toxicity Induced by Lachesis muta muta (Viperidae: Crotalinae) Venom in Rats

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