Extratos de Curcuma longa L. e Kalanchoe brasiliensis Camb. no tratamento local do envenenamento por Bothrops alternatus

Fonseca, Felícia; Melo, Marília Martins; Silva, Jéssica Moreira Batista da; Pereira, Gabriely Pinto; Dantas-Barros, A.M.

doi:10.1590/s0102-695x2004000300011

Cited by 15 publications

(11 citation statements)

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“…In the literature, few reports about the chemical constituents and pharmacology of K . brasiliensis were found [9, 10, 11], while several chemical and pharmacological studies for K . pinnata were described [12, 13, 14, 15].…”

Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Hydroethanolic Leaf Extracts of Kalanchoe brasiliensis and Kalanchoe pinnata (Crassulaceae) against Local Effects Induced by Bothrops jararaca Snake Venom

et al. 2016

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The species Kalanchoe brasiliensis and Kalanchoe pinnata, both known popularly as “Saião,” are used interchangeably in traditional medicine for their antiophidic properties. Studies evaluating the anti-venom activity of these species are scarce. This study aims to characterize the chemical constituents and evaluate the inhibitory effects of hydroethanolic leaf extracts of K. brasiliensis and K. pinnata against local effects induced by Bothrops jararaca snake venom. Thin Layer Chromatography (TLC) and High Performance Liquid Chromatography coupled with Diode Array Detection and Electrospray Mass Spectrometry (HPLC-DAD-MS/MS) were performed for characterization of chemical markers of the extracts from these species. For antiophidic activity evaluation, B. jararaca venom-induced paw edema and skin hemorrhage in mice were evaluated. In both models, hydroethanolic extracts (125–500 mg/kg) were administered intraperitoneally in different protocols. Inhibition of phospholipase enzymatic activity of B. jararaca was evaluated. The HPLC-DAD-MS/MS chromatographic profile of extracts showed some particularities in the chemical profile of the two species. K. brasileinsis exhibited major peaks that have UV spectra similar to flavonoid glycosides derived from patuletin and eupafolin, while K. pinnata showed UV spectra similar to flavonoids glycosides derived from quercetin and kaempferol. Both extracts significantly reduced the hemorrhagic activity of B. jararaca venom in pre-treatment protocol, reaching about 40% of inhibition, while only K. pinnata was active in post-treatment protocol (about 30% of inhibition). In the antiedematogenic activity, only K. pinnata was active, inhibiting about 66% and 30% in pre and post-treatment protocols, respectively. Both extracts inhibited phospholipase activity; however, K. pinnata was more active. In conclusion, the results indicate the potential antiophidic activity of Kalanchoe species against local effects induced by B. jararaca snake venom, suggesting their potential use as a new source of bioactive molecules against bothropic venom.

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Section: Introductionmentioning

confidence: 99%

Inhibitory Effects of Hydroethanolic Leaf Extracts of Kalanchoe brasiliensis and Kalanchoe pinnata (Crassulaceae) against Local Effects Induced by Bothrops jararaca Snake Venom

et al. 2016

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“…Of these, 17 (70.8 %) had not been previously reported as having anti-snakebite properties and only the following 7 (29.1 %) had already been the subject of scientific studies proving their anti-snakebite properties: Kalanchoe brasiliensis (Fonseca et al, 2004), Marsypianthes chamaedrys (Castro et al, 2003;Magalhães et al, 2011), Plathymenia reticulata (Farrapo et al, 2010;, Connarus favosus, Philodendron megalophyllum, Aniba fragrans and Bellucia dichotoma (Moura et al, 2014). that all the extracts contained more condensed than hydrolyzable tannins.…”

Section: Discussionmentioning

confidence: 99%

Plants used to treat snakebites in Santarém, western Pará, Brazil: An assessment of their effectiveness in inhibiting hemorrhagic activity induced by Bothrops jararaca venom

Moura

Freitas-de-Sousa

Dos-Santos

et al. 2015

Journal of Ethnopharmacology

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“…Algumas dessas já tiveram seus aspectos terapêuticos estudados (Jorge, 1980), como as espécies Croton urucurana (Mattos, 2001;Oliveira et al, 2008) e a Kalanchoe brasiliensis (Martins et al, 1982;Fonseca et al, 2004), e outras ainda não. Dentre estas, está a Pectis jangadensis (S.Moore) (Mendonça, 2005), conhecida localmente como "roxinha", "ervade-carregador" ou ainda, "coentro da chapada".…”

Section: Introductionunclassified

Atividade analgésica do extrato da Pectis jangadensis (S. Moore)

Soares¹,

Marques²,

Rigolin³

et al. 2009

Rev. bras. farmacogn.

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RESUMO:A planta Pectis jangadensis, popularmente conhecida como "roxinha", "erva do carregador" ou "coentro da chapada" é utilizada em chás pela população matogrossense, como calmante. Não há estudo na literatura sobre qualquer atividade farmacológica dessa planta. Nosso objetivo foi avaliar atividade analgésica de seu extrato hidro-alcoólico nas doses de 100, 500 e 1000 mg/kg pelos métodos de Contorções induzidas pelo ácido acético e teste da formalina. Os nossos resultados demonstram que não houve diferença significativa entre o grupo controle e os grupos tratados com diferentes doses do extrato tanto em relação ao número de contorções induzidas pelo ácido acético quanto ao tempo de lambedura da pata, na fase 1 e 2, induzida pela formalina. Portanto, pelo menos, por via oral, parece que o extrato hidro-alcoólico da Pectis jangadensis não apresenta atividade analgésica. Unitermos:Pectis jangadensis, Asteraceae, atividade analgésica, "roxinha". ABSTRACT: "Preliminary evaluation of Pectis jangadensis (S. Moore) analgesic activity's".The plant Pectis jangadensis, popularly known as "roxinha", "erva do carregador" or "coentro da chapada" is used in teas by the matogrossense's people, as a calmative. There isn't any study in the literature about its pharmacologic activity. Our object was to evaluate its extract hidroalcoolic analgesic activity in doses of 100, 500 and 1000 mg/kg by the methods of abdominal writhing induced by acetic acid and the Formalin test. The results show that there wasn't significant difference between the control groups and the groups treated with different doses of the extract in both testes. Therefore, at least by oral, seems that the Pectis jangadensis' hidroalcoolic extract doesn't have analgesic activity.

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Extratos de Curcuma longa L. e Kalanchoe brasiliensis Camb. no tratamento local do envenenamento por Bothrops alternatus

Cited by 15 publications

References 2 publications

Inhibitory Effects of Hydroethanolic Leaf Extracts of Kalanchoe brasiliensis and Kalanchoe pinnata (Crassulaceae) against Local Effects Induced by Bothrops jararaca Snake Venom

Inhibitory Effects of Hydroethanolic Leaf Extracts of Kalanchoe brasiliensis and Kalanchoe pinnata (Crassulaceae) against Local Effects Induced by Bothrops jararaca Snake Venom

Plants used to treat snakebites in Santarém, western Pará, Brazil: An assessment of their effectiveness in inhibiting hemorrhagic activity induced by Bothrops jararaca venom

Atividade analgésica do extrato da Pectis jangadensis (S. Moore)

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