Substâncias isoladas das folhas de Bauhinia microstachya (Raddi) Macbr. (Caesalpiniaceae)

Bianco, Éverson Miguel; Santos, Cid Aimbiré de Moraes

doi:10.1590/s0102-695x2003000200005

Cited by 8 publications

(6 citation statements)

References 11 publications

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“…The doublet centered at δ H 5.97 with J = 9:55 Hz, typical for trans-diaxial coupling, was attributed to H-1" from anomeric carbon. The signals observed between δ H 3.00 and 5.00 combined with data from the literature suggest the structure of a glucose moiety (Bianco & Santos 2003). The positioning of the sugar at C-8 was confirmed by heteronuclear multiple bond correlation (HMBC) through the correlations between H-1" and the signal at δ C 157.5 (C-9) and between H-6 and the carbons of ring A, especially the correlation with the signals at δ C 164.8 (C-7), δ C 165.1 (C-5), δ C 105.4 (C-10).…”

Section: Resultssupporting

confidence: 52%

Evaluation of the antigenotoxic and antioxidant activity induced by Croton antisyphiliticus

Silva

Figueiredo

Gomes

et al. 2020

An. Acad. Bras. Ciênc.

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This study aimed to investigate antigenotoxicity and antioxidant potential of extract, fractions and vitexin from C. antisyphiliticus. Methanolic extract was fractionated through solvents of increasing polarity. The composition of extracts and fractions were evaluated through phytochemical screening. Micronucleus test was performed in mice to evaluate the antigenotoxicity. Antioxidant activity was measured using the assay 1,1-diphenyl-2-picrylhydrazyl (DPPH), iron ion chelating, thiobarbituric acid assay and nitric oxide scavenging. Treatment with extract, fractions and vitexin did not produce an increase in Micronucleus mean values. However, Micronucleus (MN) mean values decreased in relation to control. methanolic extract presented antioxidant potential for DPPH (81%), iron ion chelating (77.8%), Thiobarbituric Acid (TBARS) (32.49%) and Nitric Oxide (NO) (80.97%). Ethyl acetate fraction showed the highest antioxidant activity (65.46%). The vitexin showed a Inhibitory Concentration (IC50) of DPPH value smaller in relation to control. Vitexin fl avonoid was detected by High Performance Liquid Chromatography (HPLC), infrared spectrometry and nuclear magnetic resonance. It can be inferred that methanolic extract, fraction ethyl acetate and vitexin isolated from C. antisyphiliticus is endowed with antigenotoxic and antioxidant potential.

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Section: Resultssupporting

confidence: 52%

Evaluation of the antigenotoxic and antioxidant activity induced by Croton antisyphiliticus

Silva

Figueiredo

Gomes

et al. 2020

An. Acad. Bras. Ciênc.

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“…The vitexin spectrum shows absorption bands corresponding to the functional groups –OH, C=C (aromatic), H–C (aromatic) and O–C (aromatic), respectively 3200-3650 cm −1 , 1450-1600 cm −1 , 3050 -3150 cm −1 and 1000-1300 cm −1 , as described by [ 40 ]. The absorption of conjugated carbonyl and intramolecular hydrogen bonding occurs approximately at 1665 cm −1 and medium-sized signals between 1600 and 1500 cm −1 also indicate the presence of aromatic groups in this molecule [ 41 ].…”

Section: Resultsmentioning

confidence: 99%

Inclusion of vitexin in β-cyclodextrin: preparation, characterization and expectorant/antitussive activities

Costa

Menezes

Almeida

et al. 2020

Heliyon

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The study aimed to include the isolated vitexin of Jatropha mutabilis in the β-cyclodextrin cavity to improve the solubility of this flavone. Its characterization was performed by techniques such as 1 H NMR/ROESY (Nuclear Magnetic Resonance Spectroscopy), FT-IR (Infrared Spectroscopy with Fourier Transform), SEM (Morphological analysis of IC by Scanning Electron Microscopy) and dissolution study in vitro . In addition, the following activities were evaluated in the animal models: expectorant, phenol red dosage in bronchoalveolar lavage and antitussive, cough induced by citric acid. In the characterization of the complex, interaction between hydrogens of ring B of vitexin and (H3) of β-CD was observed, in addition to changes in morphology. In the dissolution test, an increase in the rate of dissolution of vitexin was observed in the first 30 min for the CI vitexin/β-CD when compared with vitexin. Regarding the pharmacological activity, it was observed that the inclusion complex (IC) vitexin/β-CD in the equivalent doses of 0.2, 1 and 5 mg/kg of flavone presented higher expectorant activity when compared to vitexin (p < 0.05), suggesting increased bioavailability. As for the antitussive activity, both vitexin and the complex had similar effects and were dose independent. In the toxicity test using Artemia salina , vitexin and IC vitexin/β-CD were considered non-toxic. At last, the study efficacy of vitexin/β-CD IC as an expectorant and of vitexin as antitussive. All of these data are being described for the first time.

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“…Reddy et al (2003) More recently, Rao et al (2008), searching for new antiinflammatory natural agents, isolated six known flavonoids from the aerial parts of B. variegata, namely kaempferol, ombuin, kaempferol 7,4′-dimethyl ether 3-O-β-Dglucopyranoside, kaempferol 3-O-β-D-glucopyranoside, isorhamnetin 3-O-β-D-glucopyranoside and hesperidin, together with one triterpene caffeate, 3-β-trans-(3,4dihydroxycinnamoyloxy) olean-12-en-28 oic acid. Another species, B. microstachya, showed the presence of phenolic metabolites (da Silva and Cechinel Filho, 2002) as well as vitexin, methyl gallate and hexatriacontane (Bianco and Santos, 2003). Pettit et al (2006) Almeida et al, 2004).…”

Section: Phytochemical Knowledge Of the Genus Bauhiniamentioning

confidence: 99%

Chemical composition and biological potential of plants from the genusBauhinia

Filho

2009

Phytotherapy Research

138

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Plants of the genus Bauhinia (Fabaceae, Leguminosae), commonly known as cow's-paw or cow's hoof, are widely distributed in most tropical countries and have been used frequently in folk medicine to treat different kinds of pathologies, particularly diabetes, infections, as well as pain and inflammation. In recent years, interest in these plants has increased considerably throughout the world. The biological properties of different phytopreparations and pure metabolites have been investigated in numerous experimental in vivo and in vitro models. Although some contradicting evidence has been documented, in general, the results support the reported therapeutic properties, indicating that they are mainly due to the presence of flavonoids. This review summarizes the recent chemical and biological knowledge of plants of the genus Bauhinia.

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Substâncias isoladas das folhas de Bauhinia microstachya (Raddi) Macbr. (Caesalpiniaceae)

Cited by 8 publications

References 11 publications

Evaluation of the antigenotoxic and antioxidant activity induced by Croton antisyphiliticus

Evaluation of the antigenotoxic and antioxidant activity induced by Croton antisyphiliticus

Inclusion of vitexin in β-cyclodextrin: preparation, characterization and expectorant/antitussive activities

Chemical composition and biological potential of plants from the genusBauhinia

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