Achados principais de exames laboratoriais no diagnóstico de apendicite aguda: uma avaliação prospectiva

Goulart, Rafael Nunes; Silvério, Gilson de Souza; Moreira, Marcelo Borges; Franzon, Orli

doi:10.1590/s0102-67202012000200005

Cited by 15 publications

(8 citation statements)

References 18 publications

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“…We also are able to reveal the capability of NLR to differentiate between simple and complicated appendicitis in children with sensitivity and cutoff value of ~0.85 and 6.59, respectively. Increasing levels of NLR will happen at the early stage of appendix inflammation and continue to increase in 85–95% patients with severe infection process such as in complicated appendicitis [7,13]. These findings were similar to other previous studies, with varying cutoff values between 5 and 8 [6,7].…”

Section: Discussionsupporting

confidence: 89%

Accuracy of neutrophil lymphocyte ratio for diagnosis of acute appendicitis in children: A diagnostic study

Prasetya

Rochadi

Gunadi

2019

Annals of Medicine and Surgery

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BackgroundMany biomarkers for diagnosis of acute appendicitis in children have been reported, however, the results are still controversial. We assessed the accuracy of neutrophil-lymphocyte ratio (NLR) for diagnosis of acute appendicitis and discriminating simple and complicated appendicitis in children.MethodsWe included 121 patients with acute appendicitis and 49 children with intussusception as controls who were admitted at our hospital from 2013 to 2017. White blood count (WBC), neutrophil, and NLR were compared between groups.ResultsNeutrophil and NLR were significantly higher in the acute appendicitis group than control (76.17 ± 14.41 vs. 62.43 ± 15.9%, p=<0.0001; and 8.44 ± 6.63 vs. 3.38 ± 2.84, p=<0.0001, respectively), while WBC, neutrophil, and NLR were significantly greater in complicated than simple appendicitis (15.86 ± 6.48 vs. 12.64 ± 6.27 × 103/μL, p = 0,008; 82.64 ± 8.41 vs. 68.99 ± 16.23%, p=<0.0001; and 11.32 ± 6.87 vs. 5.25 ± 4.65, p=<0.0001, respectively). The sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), area under the receiver operating characteristic (ROC) curve, and cutoff point of NLR for diagnosis of acute appendicitis were 83.5%, 57.7%, 81.4%, 61.2%, 0.764, and 2.87, respectively; whereas the sensitivity, specificity, PPV, NPV, area under the ROC curve, and cutoff point of NLR for differentiating complicated and simple appendicitis were 84.6%, 56.5%, 35.5%, 92.9%, 0.790, and 6.59, respectively.ConclusionNLR shows a high accuracy for diagnosis of acute appendicitis and distinguishing a complicated appendicitis from the simple one.

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Section: Discussionsupporting

confidence: 89%

Accuracy of neutrophil lymphocyte ratio for diagnosis of acute appendicitis in children: A diagnostic study

Prasetya

Rochadi

Gunadi

2019

Annals of Medicine and Surgery

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“…Patients sample size obtained in the interval of time considered was similar to that calculated in national and international clinical trials studying the same clinical subject 2 , 9 , 11 , 17 . The fact that acute appendicitis occurs mainly in young males is well established in medical literature 8 , 10 , and the sample included in this study showed the same pattern, considering that the number of males was almost two times the number of females, and the majority of the patients were 30 years of age or less.…”

Section: Discussionmentioning

confidence: 55%

“…Acute appendicitis is a condition that can be diagnosed mainly by its clinical features 8 , 10 , 19 , 20 ; however, in this sample only 4% had a purely clinical diagnosis. In 19,1% of them only one complementary exam was necessary (white blood cells count or ultrasound).…”

Section: Discussionmentioning

confidence: 69%

Hospitalization time after open appendectomy by three different surgical techniques

Ximenes

Mello

Lima-Júnior

et al. 2014

ABCD, arq. bras. cir. dig.

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BackgroundThe choice of surgical technique to approach the appendicular stump depends mostly on skill and personal preference of the surgeon or on the protocol used in the service, and the influence of this choice in hospitalization time is not evaluated.AimTo evaluate the relation between surgical technique and postoperative hospitalization time in patients presenting with acute appendicitis.MethodsRetrospective analysis of 180 patients who underwent open appendectomy. These where divided into three groups according to surgical technique: conventional appendectomy (simple ligation of the stump), tobacco pouch suture and Parker-Kerr suture. Data where crossed with hospitalization time (until three days, from four to six days and over seven days).ResultsA hundred and eighty patients with age from 15 to 85 years where included. From these, 95 underwent conventional technique, had an average hospitalization time of 3,9 days and seven had complications (surgical site infection, seroma, suture dehiscence and evisceration). In 67 patients, tobacco pouch suture was chosen and had average hospitalization time of 3,7 days and two complications (infection and seroma). In 18 Parker-Kerr suture was made, with average hospitalization time of 2,6 days, with no complication. Contingency coefficient between the variables hospitalization time and technique was 0,255 and Cramér's V was 0,186.ConclusionThere was tendency to larger hospitalization time and larger number of complications in conventional appendectomy, whereas in patients where Parker-Kerr suture was performed, hospitalization time was significantly smaller.

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“…When criteria were analyzed in a isolated manner, as previously described by other authors, was noticed that CRP and segmented neutrophils show direct relation with the acute appendicitis stage. CRP was below 50 in patients in stage 1 and segmented neutrophils below 85% in 95% of the cases, and in stage 4, CRP was above 50 and segmented neutrophils above 85% in 60% of patients 10 .…”

Section: Discussionmentioning

confidence: 86%

Air Score Assessment for Acute Appendicitis

Von-Mühlen

Franzon

Beduschi

et al. 2015

ABCD, arq. bras. cir. dig.

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Background: Acute appendicitis is the most common cause of acute abdomen. Approximately 7% of the population will be affected by this condition during full life. The development of AIR score may contribute to diagnosis associating easy clinical criteria and two simple laboratory tests. Aim: To evaluate the score AIR (Appendicitis Inflammatory Response score) as a tool for the diagnosis and prediction of severity of acute appendicitis. Method: Were evaluated all patients undergoing surgical appendectomy. From 273 patients, 126 were excluded due to exclusion criteria. All patients were submitted o AIR score. Results: The value of the C-reactive protein and the percentage of leukocytes segmented blood count showed a direct relationship with the phase of acute appendicitis. Conclusion: As for the laboratory criteria, serum C-reactive protein and assessment of the percentage of the polymorphonuclear leukocytes count were important to diagnosis and disease stratification.

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Achados principais de exames laboratoriais no diagnóstico de apendicite aguda: uma avaliação prospectiva

Cited by 15 publications

References 18 publications

Accuracy of neutrophil lymphocyte ratio for diagnosis of acute appendicitis in children: A diagnostic study

Accuracy of neutrophil lymphocyte ratio for diagnosis of acute appendicitis in children: A diagnostic study

Hospitalization time after open appendectomy by three different surgical techniques

Air Score Assessment for Acute Appendicitis

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