Risk factors for acquired multidrug-resistant tuberculosis

Abstract

Multidrug-resistant tuberculosis (MDR-TB) is a severe and feared problem, that is difficult to control and has shown a tendency to increase worldwide.

Risk factors of Multidrug Resistant Tuberculosis in central Nepal: A pilot study

“…21 Also in another study, smoking appeared as one of the risk factors for MDR TB. 22 Smoking was found to be associated with isoniazid resistance but more evidence is needed to explain this association. 24 However, a studyconducted in Korea amongst the military worker found no significant differences in terms of smoking history (P=0.658).…”

“…39 In another study, alcoholism appeared as one of the risk factors for MDR TB. 22 Social stigma and lack of scientific awareness about the disease and social commitments are stated reasons for interrupting and defaulting TB treatment. In our study, association between social stigma and having MDR TB is significant with OR 2.655 (95%CI 1.071 to 5.159) (p=0.013)…”

“…27 Another study revealed that a lower number of rooms in the house can also be associated with MDR TB. 22 Although a full knowledge of tuberculosis transmission and spectrum of disease are not crucial in finishing a course of medicine, it is a reflection of how well patients are being educated about their illness. Knowledge regarding MDR TB and DOTS Plus was significantly high amongst MDR TB patients.…”

“…22 Larger case control studies will be required to determine whether or not the socio-economic factors and poor knowledge leading to poor adherence to treatment thereby leading to the development of MDR-TB are proven.…”

Drug resistance of Mycobacterium tuberculosis strains in southern Brazil

“…M. tuberculosis presents a significant frequency of naturally resistant mutants: 1:106 for isoniazide, 1:108 for rifampicin, but less than 1:1014 for both simultaneously. Misuse of the drugs certainly contributes to the selection of resistant strains 13,17 .…”