Pleurodesis induced by intrapleural injection of silver nitrate or talc in rabbits: can it be used in humans?

Vargas, Francisco S.; Antonângelo, Leila; Vaz, Marcelo A.C.; Marchi, Evaldo; Capelozzi, Vera Luíza; Genofre, Eduardo H.; Teixeira, Lisete R.

doi:10.1590/s0102-35862003000200003

Cited by 1 publication

(1 citation statement)

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“…Treatment consists of inducing symphysis between parietal and visceral pleural surfaces by injection of a sclerosing agent into the pleural space (Rodriguez-Panadero & Antony, 1997 ; Shaw & Agarwal, 2013 ; Mierzejewski et al., 2019 ). Talc is the most frequently used pleurodesis agent (Adler & Sayek, 1976 ; Walker-Renard et al., 1994 ; Vargas et al., 2003 ).…”

Section: Introductionmentioning

confidence: 99%

A mechanism for improved talc pleurodesis via foam delivery

et al. 2021

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Talcum powder is recognized as the leading drug for pleurodesis, a treatment of choice for malignant pleural effusions. Recently, it was shown that hydrogel foam delivery systems significantly enhanced the number of adhesions between the chest wall and the lung in a New Zealand rabbit model due to the sol-gel transition. However, many questions still remain regarding the cause of improved efficacy, such as: (1) Would only hydrogel foams improve the efficacy of talc pleurodesis? (2) Is it possible to achieve the same efficacy of hydrogels using non-hydrogel foams? 3) What are the physicochemical properties that can be correlated to the efficacy of talc pleurodesis? In this study, we use non-hydrogel foam formulations to determine the efficacy of pleurodesis. Foam stability and rheology of the formulations were correlated to adhesion formation. The results clearly suggest a correlation of pleurodesis efficacy to the viscosity and modulus of the foam delivery system.

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