Pleurodesis: what agent should be used?

Light, Richard W.

doi:10.1590/s0102-35862003000200001

Cited by 4 publications

(2 citation statements)

References 11 publications

(13 reference statements)

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“…As is already known, the irritants cause reaction between the parietal and visceral layers of the pleura, which closes off the space between them and prevents further fluid from accumulating. On the other hand, the technique can sometimes be challenging to achieve pleurodesis in HH because of the rapid fluid accumulation [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…To date, a large number of chemicals were considered to induce pleurodesis in malignant or non-malignant effusions. Although talc, tetracycline derivatives, OK-432, bleomycin, or povidone–iodine are the most commonly used agents for liver-related pleurodesis, availability, side effects, and variable results are still major concerns [ 16 , 18 – 25 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of nonsurgical tigecycline pleurodesis for the management of hepatic hydrothorax in patients with liver cirrhosis

Yılmaz

Zeybek

Tharian³

et al. 2015

surg case rep

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Chemical pleurodesis is one of the therapeutic tools to control hepatic hydrothorax. Tetracycline and derivatives have been widely accepted as an effective and safe treatment for the purpose, but availability is the big concern. Tigecycline is an antibiotic derivative of tetracycline, which has demonstrated to be an effective pleurodesing agent in animal models. The aim of the study was to document two successful tigecycline pleurodesis in patients with decompensated liver cirrhosis, who were not candidates for liver transplantation. Both patients were undergoing palliative treatment for cirrhosis and developed massive pleural effusion on the right side. They underwent chemical pleurodesis in the first instance. Diagnostic thoracocentesis was done to rule out differentials and to confirm the clinical suspicion, following which, complete drainage of pleural fluids was achieved. Tigecycline of 3 mg/kg was instilled intrapleurally via the thoracic catheter, as per the protocol. The medical records and images were thoroughly reviewed. There was no recurrence of the effusion for at least 3 months, with no detected complications in the short- or long-term follow-up. In conclusion, pleurodesis with tigecycline seems to be effective and safe for the management of symptomatic hepatic hydrothorax and should therefore be promoted in the setting of liver cirrhosis at least for a short-term relief, especially in patients who do not meet the criteria for liver transplantation.

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Section: Introductionmentioning

confidence: 99%