2013
DOI: 10.1590/s0102-311x2013000100017
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Prevalência e distribuição espacial de defeitos do tubo neural no Estado de São Paulo, Brasil, antes e após a fortificação de farinhas com ácido fólico

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Cited by 15 publications
(15 citation statements)
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“…Although folic acid supplementation is still recommended in the three months preceding pregnancy and in the first trimester of pregnancy, our findings suggest that it is still scarcely practiced among pregnant women in the country. Anyway, in Brazil, there has been a great improvement regarding the intake of folic acid since the Brazilian government established the mandatory fortification of wheat and maize flour with iron and folic acid, which brought about positive results in preventing neural tube defects (25) . Our results also show that the demand for medical assistance was the most cited preconception measure, which is an important issue, as women who undergo counseling by health professionals before pregnancy are more likely to adopt preconception health behaviors (5) .…”
Section: Discussionmentioning
confidence: 99%
“…Although folic acid supplementation is still recommended in the three months preceding pregnancy and in the first trimester of pregnancy, our findings suggest that it is still scarcely practiced among pregnant women in the country. Anyway, in Brazil, there has been a great improvement regarding the intake of folic acid since the Brazilian government established the mandatory fortification of wheat and maize flour with iron and folic acid, which brought about positive results in preventing neural tube defects (25) . Our results also show that the demand for medical assistance was the most cited preconception measure, which is an important issue, as women who undergo counseling by health professionals before pregnancy are more likely to adopt preconception health behaviors (5) .…”
Section: Discussionmentioning
confidence: 99%
“…Added to food, this has a bioavailability 85-100% , while folate, in its natural form, present in fresh food, has a bioavailability of 50%, and is more susceptible to destruction in the preparation. 11,12 A daily dosage of 0.4 mg of folic acid is recommended for all women who plan to become pregnant; for those who have had children with problems or who use medications that interfere with folate levels in the body, such as anticonvulsants, the recommend dose is 4mg. 12 For lactating and pregnant women, an additional daily dose of 0.1 mg and 0.2 mg of folic acid is recommended, respectively.…”
Section: Introductionmentioning
confidence: 99%
“…11,12 A daily dosage of 0.4 mg of folic acid is recommended for all women who plan to become pregnant; for those who have had children with problems or who use medications that interfere with folate levels in the body, such as anticonvulsants, the recommend dose is 4mg. 12 For lactating and pregnant women, an additional daily dose of 0.1 mg and 0.2 mg of folic acid is recommended, respectively. The use of folic acid is recommended three months prior to gestation through the 12th week of gestation.…”
Section: Introductionmentioning
confidence: 99%
“…Randomized clinical trials and several observational studies showed that 50% to 85% of the cases of NTD can be prevented if women receive folic acid supplementation at a daily dose of 0.4 mg daily in the periconceptional period 2,13 . Considering the low adherence to medicine supplementation by the population, and in order to reduce the prevalence of maternal anemia and neural tube defects, the Brazilian government established the mandatory fortification of wheat and maize flour with iron and folic acid, which was effectively implemented in the country from June 2004 14 .…”
mentioning
confidence: 99%