Persistência dos sintomas de dengue em uma população de Uberaba, Minas Gerais, Brasil

Teixeira, Luciana de Almeida Silva; Lopes, Juliana Salviano Mendonça; Costa-Martins, André G.; Campos, Fernando Augusto Batista; Miranzi, Sybelle de Souza Castro; Nascentes, Gabriel Antônio Nogueira

doi:10.1590/s0102-311x2010000300019

Cited by 29 publications

(12 citation statements)

References 5 publications

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“…In contrast to a retrospective study previously published by our group, the prospective follow-up of patients in the present study provided more reliable information. Nevertheless, the prevalence of persistent symptoms was similar to that found in the previous retrospective study, 50-60% 10 .…”

Section: Discussionsupporting

confidence: 89%

“…Another specific chart was used during the outpatient follow-up to record the spontaneous complaints of the patients and then applying the objective inquiry about the presence of fever, headache, retro-orbital pain, myalgia, exanthema, prostration, arthralgia, nausea, vomiting, diarrhea, sleepiness, weakness, coryza, cough, hair loss, cognitive state, memory loss, reasoning problems and skin changes. The objective signs were extracted from a survey of symptoms reported in a previous study 10 . All visits were conducted by at least one of the two participating physicians.…”

Section: Methodsmentioning

confidence: 99%

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Prospective study of patients with persistent symptoms of dengue in Brazil

Teixeira

Nogueira

Nascentes

2017

Rev. Inst. Med. trop. S. Paulo

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Dengue is an arboviral infection clinically recognized as an acute and self-limited disease. Persistence of dengue symptoms is known, but it has been little studied. The aim of this study was to characterize persistent symptoms in 113 patients with dengue followed up clinically and by laboratory testing at a tertiary hospital. Symptoms that persisted for more than 14 days were observed in 61 (54.0%) patients, and six (6.2%) of them had symptoms for 6 months or more. The persistent symptoms identified were myalgia, weakness, hair loss, memory loss, reduced resistance to physical effort, headache, reasoning problems, arthralgia, sleepiness- and emotional lability. The progression to persistent symptoms was significantly associated with hospitalization, older age, more severe disease, the presence of bleeding and comorbidities upon univariate analysis. Upon multivariate analysis, the presence of persistent symptoms continued to be significantly associated only with increased age and dengue with warning signs. The platelet count during the acute phase of the disease was significantly lower in the group with persistent symptoms. In conclusion, the frequency of progression to persistent symptoms in dengue is relevant in patients seen at a tertiary hospital and the persistence of symptoms is more common in patients with dengue with warning signs.

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Section: Discussionsupporting

confidence: 89%

Section: Methodsmentioning

confidence: 99%

Prospective study of patients with persistent symptoms of dengue in Brazil

Teixeira

Nogueira

Nascentes

2017

Rev. Inst. Med. trop. S. Paulo

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“…This was based on a study by Teixeira et al . [26] . However, other studies have not found the same degree of post-acute consequences, and this requires further investigation [27] .…”

Section: The Estimated Daly Burden Of Dengue In Vietnammentioning

confidence: 99%

“…The current economic burden estimates do not account for the potential burden and income loss associated with symptoms that persist after resolution of the acute dengue episode, such as depression, profound fatigue, and weight loss 26 , 27 , 49 , 50 . A study in Mexico indicated that accounting for these persistent symptoms could increase the estimated economic burden of dengue by approximately 13% [27] .…”

Section: Data Gaps and Future Research Needsmentioning

confidence: 99%

The Estimates of the Health and Economic Burden of Dengue in Vietnam

Hung

Clapham

Bettis

et al. 2018

Trends in Parasitology

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Dengue has been estimated to cause a substantial health and economic burden in Vietnam. The most recent studies have estimated that it is responsible for 39 884 disability-adjusted life years (DALYs) annually, representing an economic burden of US$94.87 million per year (in 2016 prices). However, there are alternative burden estimates that are notably lower. This variation is predominantly due to differences in how the number of symptomatic dengue cases is estimated. Understanding the methodology of these burden calculations is vital when interpreting health economic analyses of dengue. This review aims to provide an overview of the health and economic burden estimates of dengue in Vietnam. We also highlight important research gaps for future studies.

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“…Su etiología aún no se ha descrito con precisión, de la fase aguda, entre los cuales predominó el cansancio físico (65,6 %), la cefalea (37,5 %), el insomnio (31,3 %), el mareo, el cansancio mental (25 %) y el dolor muscular (18,8 %). Estos hallazgos coinciden con las observaciones registradas en otros estudios (16,(28)(29)(30). Al evaluar la presencia de fatiga física y mental después de la infección aguda por dengue, se evidenció que esta se mantuvo en 34,4 % de los pacientes durante su convalecencia, con síntomas como el Convalecencia de la infección del dengue Figura 2.…”

Section: Discussionunclassified

Caracterización del estado de salud de las personas en su periodo de convalecencia de un episodio de dengue

et al. 2015

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Introducción. El dengue y sus manifestaciones agudas se han descrito ampliamente en la literatura, sin embargo, los síntomas en la fase de convalecencia se han estudiado poco. Objetivo. Describir las manifestaciones clínicas de una población durante su periodo de convalecencia de un episodio de dengue. Materiales y métodos. Se hizo un estudio observacional en sujetos que estuvieron hospitalizados con dengue diagnosticado por serología. Después del alta se les visitó para evaluar la persistencia de la sintomatología clínica, la fatiga (evaluada mediante el Fatigue Questionnaire de Chalder) y la calidad de vida (evaluada mediante el cuestionario EuroQoL-5D). Se determinó como fatiga significativa aquella con un puntaje igual o superior a cuatro en la escala empleada. Se hizo seguimiento telefónico y domiciliario de los participantes con fatiga hasta tres meses después del alta hospitalaria. Resultados. La prevalencia de fatiga en los 32 sujetos seleccionados (edad media: 35 años, sexo femenino: 59 %) fue de 34,4 % (IC95% 17,0-51,8). No se observaron diferencias sociodemográficas en relación con la fatiga, pero sí con relación a una mayor frecuencia de cansancio físico (100,0 % Vs. 47,6 %; p=0,005) y mental (54,6 % Vs. 9,5 %; p=0,010). Aunque los pacientes con fatiga reportaron una peor calidad de vida, esta no fue estadísticamente diferente a la del grupo sin fatiga al ajustar por edad y sexo (OR=5,5; IC95% 0,83-36,5). Además, el puntaje de fatiga decayó en promedio medio punto por cada diez días de seguimiento (p=0,007). Conclusiones. Estos resultados demuestran que la carga de enfermedad de la infección por el virus del dengue no se ha descrito del todo, pues en la fase de convalecencia se siguen presentando síntomas clínicos que dificultan la recuperación normal del individuo.

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Persistência dos sintomas de dengue em uma população de Uberaba, Minas Gerais, Brasil

Cited by 29 publications

References 5 publications

Prospective study of patients with persistent symptoms of dengue in Brazil

Prospective study of patients with persistent symptoms of dengue in Brazil

The Estimates of the Health and Economic Burden of Dengue in Vietnam

Caracterización del estado de salud de las personas en su periodo de convalecencia de un episodio de dengue

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