Decreased intelligence in children and exposure to fluoride and arsenic in drinking water

Rocha-Amador, Diana Olivia; Navarro, María Elena; Carrizales, Leticia; Morales, R.; Calderón, Jaqueline

doi:10.1590/s0102-311x2007001600018

Cited by 158 publications

(88 citation statements)

References 13 publications

(17 reference statements)

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“…17 Saxena et al and Shivaprakash et al in their study have also demonstrated that intellectual capacity of children decreases with increase in the fluorosis grade. 6,19 Data from previous studies support to the hypothesis that interaction between fluoride, lead, and arsenic could worsen the children's intelligence grades, 20 and thus, indicate a need for further investigation. Guan et al demonstrated that the contents of phospholipids and ubiquinone are altered in the brain of rats affected by chronic fluorosis, and therefore changes in membrane lipids could be a cause of this disorder.…”

Section: Discussionmentioning

confidence: 77%

Effect of Fluoride Exposure Through Drinking Water on the Oral Health Status and Intelligence Profile of School Children of District Una, Himachal Pradesh: An Interim Analysis

Sharma¹,

Singh²,

Kumar³

et al. 2016

jemds

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BACKGROUND This interim analysis of an ongoing project aims to study the association of fluoride levels with dental fluorosis and intelligence among children of 10-14 years of age in study area. MATERIALS AND METHODSThe study was conducted in randomly selected 15 government high schools of District Una, Himachal Pradesh. The analysis of seven schools is being discussed with a sample size of 270. Dean's Fluorosis index was used to study fluorosis level and Intelligence test was conducted on students by using Raven's standard progressive matrices questionnaire.Study Duration-Nine months. RESULTSDental fluorosis was observed among 11.5% of students. It was higher among females (12.4%) as compared to males (10.6%). The intelligence level assessment of student showed that all of them were in the range of above average; about 83.3% of students were having grade III (Average) level of intelligence. CONCLUSIONAs the fluorosis level increased, the proportion of children with lower intelligence increased. Based on the findings, the chronic exposure to high levels of fluoride can be one of the factors that influence intellectual development.

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Section: Discussionmentioning

confidence: 77%

Effect of Fluoride Exposure Through Drinking Water on the Oral Health Status and Intelligence Profile of School Children of District Una, Himachal Pradesh: An Interim Analysis

Sharma¹,

Singh²,

Kumar³

et al. 2016

jemds

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“…Moreover, As is a potent endocrine disruptor; thus, it may interact with estrogen and thyroid hormones, both of which are essential for brain development (Davey et al 2008). Several studies reported an association between exposure to arsenic and deleterious effects in IQ scores as well as in memory and performance domains in children aged 5-15 years (e.g., Rocha-Amador et al 2007;Hamadani et al 2011;Wasserman et al 2011). On the other hand, no significant effects were found between arsenic and behavioral disorders (Roy et al 2011;Yousef et al 2011;Khan et al 2012).…”

Section: The Effects Of Metal Co-exposurementioning

confidence: 99%

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Gorini

Muratori

Morales

2014

Rev J Autism Dev Disord

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An increasing evidence supports the role of industrial chemicals as contributors to the development of neurobehavioral disorders, including autism spectrum disorders, whose prevalence has progressively increased in recent years. Heavy metals, in particular, are recognized as neurodevelopmental toxins since they can be responsible of fetal damages which lead to neurological defects, developmental delays, learning disabilities and behavioral abnormalities. Most of the reviewed studies reported a relationship between exposure to metals during perinatal and early childhood periods and increased risk for autism. Moreover, the effects resulting from co-exposure to multiple metals should not be underestimated, especially in the assessment of children who live in developing countries or near heavily contaminated sites.

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“…The adverse effects caused by longterm exposure to inorganic As through drinking water have been widely studied. The effects reported include skin lesions, diabetes mellitus, degenerative effects on the circulatory system, and neurotoxicity (Abernathy et al 1999, Rocha-Amador et al 2007, States et al 2009, Huang et al 2011 as well as certain types of skin, urinary tract, liver, and lung cancers (Tapio and Grosche 2006, Coronado-Gonzalez et al 2007, Celik et al 2008, IARC 2012.…”

Section: Introductionmentioning

confidence: 99%

Micronucleus in Exfoliated Buccal Cells of Children From Durango, Mexico, Exposed to Arsenic Through Drinking Water

Guzmán

Salazar²,

Martínez

et al. 2017

Rev. Int. Contam. Ambie.

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Exposure to inorganic arsenic (As) via drinking water in Latin America and Mexico is a growing public health concern that requires rapid methods to assess risk and adverse effects. The measurement of micronucleus frequency (MNf) in oral mucosa is a noninvasive and low-cost method for monitoring the genotoxic damage in exposed populations. Mexican children from Durango city, a zone with high water arsenic concentrations, were selected and assigned to three-risk categories (low, medium, high) based on the use of tap or bottled water. Levels of As in water, urine and MNf, were measured. Results indicate a significant correlation between the groups at risk and the frequency of MNf in children (0.9 ± 1.9 MN, 1.1 ± 1.9, and 2.6 ± 2.2 per 1000 buccal cells, respectively); (r = 0.416; p = 0.001). Which demonstrated that the MNf in oral mucosa is an efficient and low-cost technique for assessing and monitoring DNA damage by exposure to As. This study also provides evidence that the modification of risk factors could reduce health risk.Palabras clave: genotoxicidad, contaminación natural, población vulnerable, riesgos ambientales RESUMEN La exposición a arsénico (As) inorgánico a través del agua de bebida es un problema de salud pública en América Latina y en México que requiere métodos rápidos para evaluar riesgo y efectos adversos. La medición de la frecuencia de micronúcleos (MNf) en mucosa oral es un método no invasivo y de bajo costo para monitorear daño genotóxico en población expuesta a contaminantes ambientales. Para esta investigación, O.D. López Guzmán et al. 282fueron seleccionados niños mexicanos de la ciudad de Durango, una zona con altas concentraciones de As en agua, y asignados en tres categorías de riesgo (baja, media y alta) con base en el uso de agua de la llave o agua embotellada. Se midieron los niveles de As en agua, orina y la MNf. Los resultados indican una correlación significativa entre los grupos de riesgo y la frecuencia de MNf en los niños (0.9 ± 1.9 MN, 1.1 ± 1.9, y 2.6 ± 2.2 por 1000 células bucales, respectivamente); (r = 0.416; p = 0.001). Estos resultados demuestran que la MNf en mucosa oral es una técnica eficiente y de bajo costo para evaluar y monitorear daño al ADN por la exposición a As. Este estudio también provee evidencia de que la modificación de factores de riesgo puede reducir riesgos a la salud.

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Decreased intelligence in children and exposure to fluoride and arsenic in drinking water

Cited by 158 publications

References 13 publications

Effect of Fluoride Exposure Through Drinking Water on the Oral Health Status and Intelligence Profile of School Children of District Una, Himachal Pradesh: An Interim Analysis

Effect of Fluoride Exposure Through Drinking Water on the Oral Health Status and Intelligence Profile of School Children of District Una, Himachal Pradesh: An Interim Analysis

The Role of Heavy Metal Pollution in Neurobehavioral Disorders: a Focus on Autism

Micronucleus in Exfoliated Buccal Cells of Children From Durango, Mexico, Exposed to Arsenic Through Drinking Water

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