Prevalência e determinantes maternos do consumo de medicamentos na gestação por classe de risco em mães de nascidos vivos

Geib, Lorena Teresinha Consalter; Filho, Edson Fauth Vargas; Geib, Débora; Mesquita, Débora Iasmin; Nunes, Magda Lahorgue

doi:10.1590/s0102-311x2007001000010

Cited by 17 publications

(28 citation statements)

References 13 publications

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“…Fontoura (2009) reports a prevalence similar to the one obtained in our study, where 98% of the pregnant used some kind of medicine during pregnancy. Other authors report a lower prevalence, such as 76.4%, 80.1%, and 90% (Oliveira, Fonseca, 2007;Geib et al, 2007;Brum et al, 2011).…”

Section: Resultsmentioning

confidence: 94%

“…According to Geib et al (2007), the use of class A medicines is associated with prenatal attention, reinforcing the prevention of gestational and fetal damage, since this class contains antianemics and vitamins. Drugs that belong to B, C, and D classes have their consumption associated with intercurrences of health in pregnancy, having the B class a consumption adequacy; the C class with biological factors related to history of abortion and caesarean; and the D class lower consumption in the economic classes less favored.…”

Section: Resultsmentioning

confidence: 99%

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Consumption of medicines in high-risk pregnancy: evaluation of determinants related to the use of prescription drugs and self-medication

Araújo

Leal

Santos

et al. 2013

Braz. J. Pharm. Sci.

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The use of drugs during pregnancy still represents a challenge for medicine, since the majority of drugs cross the placental barrier with a potential to cause several congenital problems to the fetus, and most of them have not been clinically tested in pregnant patients. At the same time, the medicalization phenomenon, self-medication, and lack of patient information about the misuse of medicines are additional problems. Thus, the aim of this study was to evaluate the pattern of medicine consumption in high-risk pregnancies and the determinants related to this consumption pattern. In order to do so, a cross-sectional descriptive study was performed with puerperal women who had a history of high-risk pregnancy. Statistically significant associations were found between self-medication and fewer prenatal visits, and cigarette use during pregnancy and a higher number of children. According to these data, the vulnerability of this population to the risks of drug use is evident, demonstrating a gap that requires urgent interventions in health-care education.Uniterms: Medicines/adverse effects. Pregnancy/medicines use. Self-medication. Health education.O uso de medicamentos na gestação representa, ainda hoje, um desafio para a medicina, visto que grande parte dos fármacos atravessa a barreira placentária e, na maioria, não foi testada clinicamente em gestantes, podendo vir a ocasionar diversos problemas congênitos ao feto. Ao mesmo tempo, a automedicação, o fenômeno da medicalização e a falta de informação sobre os riscos do mau uso de medicamentos são problemas adicionais. Diante disto, o objetivo deste estudo consistiu em avaliar o padrão de consumo de medicamentos na gestação de alto risco e os determinantes relacionados ao seu padrão de consumo. Para tanto, realizou-se um estudo descritivo de corte transversal com puérperas, que apresentaram gestação de alto risco. Verificaram-se associações estatisticamente significativas entre automedicação e mulheres com menor número de consultas de pré-natal, uso de cigarro na gestação e maior número de filhos. De posse destes dados, fica evidente a vulnerabilidade dessa população aos riscos decorrentes do uso de medicamentos, sendo esta lacuna um campo de prática com necessidade de intervenções urgentes no âmbito da educação em saúde.Unitermos: Medicamentos/efeitos adversos. Gestação/uso de medicametos. Automedicação. Educação em saúde.

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Section: Resultsmentioning

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Consumption of medicines in high-risk pregnancy: evaluation of determinants related to the use of prescription drugs and self-medication

Araújo

Leal

Santos

et al. 2013

Braz. J. Pharm. Sci.

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“…Dentre os medicamentos geralmente prescritos dessa forma no presente estudo estão paracetamol e escopolamina associada com paracetamol 4 . Observou-se que as gestantes acompanhadas nesta pesquisa são jovens, de baixa escolaridade e de baixa renda, tal perfil se assemelha a outros estudos nacionais [24][25][26] e internacionais [27][28][29] . Poucos estudos investigaram a exposição aos medicamentos utilizados antes do diagnóstico gestacional.…”

Section: Discussionunclassified

“…Em algumas situações o uso se manteve por seleção inapropriada do medicamento por parte da paciente ou do médico e em outras pela avaliação do custo benefício, como o caso de uma gestante com epilepsia. Portanto, a situação de saúde da gestante pode requerer o uso de medicamentos classificados como inseguros para esse estado fisiológico 19,24,33 .…”

Section: Discussionunclassified

Uso de medicamentos no primeiro trimestre de gravidez: avaliação da segurança dos medicamentos e uso de ácido fólico e sulfato ferroso

Lunardi-Maia¹,

Schuelter-Trevisol²,

Galato³

2014

Rev. Bras. Ginecol. Obstet.

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Houve diferença entre as proporções de medicamentos utilizados segundo a ATC, e os principais grupos anatômicos identificados foram os dos medicamentos que atuam no sangue e órgãos hematopoiéticos e anti-infecciosos de uso sistêmico. Na época do diagnóstico da gravidez, observou-se expressivo uso de medicamentos que atuam no sistema geniturinário e hormônios sexuais (16,2%), como anticoncepcionais orais, o que provavelmente está relacionado ao percentual de gestações não planejadas (67,0%), nessa mesma ocasião 4 gestantes utilizaram ácido fólico e 3 utilizaram o sulfato ferroso. CONCLUSÃO: Os resultados demonstram uso expressivo de medicamentos durante a gravidez. Mesmo que haja menor exposição aos medicamentos no momento do diagnóstico da gravidez, observa-se maior consumo de medicamentos de risco e da prática de automedicação nesse período. Abstract PURPOSE:To identify the profile of use of medication during the first trimester of pregnancy with emphasis on safety assessment and on the adoption of folic acid and ferrous sulfate by pregnant women attended at a Basic Health Unit in Brazil. METHODS: This was a cross-sectional study nested in a cohort of pregnant women. Medications were classified according to the Anatomical Therapeutic Chemical (ATC), and their safety was evaluated according to the Food and Drug Administration (FDA) and the Brazilian Health Surveillance Agency (ANVISA). The adoption of ferrous sulfate and folic acid was investigated according to the protocol set forth by the Brazilian Ministry of Health. RESULTS: The survey included 212 pregnant women, 46.7% of whom were taking medications at the time of pregnancy diagnosis, and 97.6% used medication during the first trimester after diagnosis. The highest percentage of self-medication occurred before the beginning of prenatal care (64.9%). According to the FDA criteria, there was a high level of exposure to D and X risk drugs before the beginning of prenatal care (23.0%), which was also observed for drugs not recommended by ANVISA (36.5%). Of the surveyed sample, 32.5% did not follow the protocol of the Brazilian Ministry of Health. In all, 67.9% of pregnant women had inadequate drug exposure. There was a difference between the proportions of

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“…The prevalence of medication use among pregnant women in Brazil varied from 80 to 94.6% (Brum et al, 2011;Fonseca et al, 2002;Geib et al, 2007). In some specific conditions, as in the cases of women that have acute or chronic comorbidities, therapeutic intervention becomes a crucial option (Lupattelli et al, 2013;Orbach et al, 2013;Torres and Moayedi, 2012).…”

Section: Introductionmentioning

confidence: 99%

Prevalence of medication use among low risk pregnant women: A drug utilization study

Fontoura¹,

Ayres²,

Martins-Nagai³

et al. 2014

Afr. J. Pharm. Pharmacol.

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This study aimed to characterize the profile of medication consumption by low risk pregnant women and to correlate it with sociodemographic characteristics of this population. A cross-sectional descriptive study was conducted in the Reference Center of Women's Health in the Brazilian municipality of Ribeirão Preto. This study included women which were at least in the 32nd week of the gestation period. Data related to sociodemographic characteristics of the pregnant women and to their pregnancy and medication consumption were collected from June, 2008 to November, 2008. A total of 699 pregnant women were included. About 20% of the pregnant women began prenatal care in the 12th week of gestation and 75.3% had at least six antenatal visits. The use of at least one drug during pregnancy was reported by 98% of the participants. The mean number of medications used was 4.35. According to the Food and Drug Administration (FDA) risk classification, 14.07% of the medication belonged to C category, 1.85% to D and 0.03% to X, and 38.30% were not identified or not classified by the FDA. When correlating the number of prenatal visits with the amount of medication used, it was verified that pregnant women who underwent less than six visits during pregnancy used a higher number of medications. Pregnant women have been exposed to a variety of medications and there is a need to improve the quality of care in order to prevent potential risks to the fetus, especially in relation to the use of medications.

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Prevalência e determinantes maternos do consumo de medicamentos na gestação por classe de risco em mães de nascidos vivos

Cited by 17 publications

References 13 publications

Consumption of medicines in high-risk pregnancy: evaluation of determinants related to the use of prescription drugs and self-medication

Consumption of medicines in high-risk pregnancy: evaluation of determinants related to the use of prescription drugs and self-medication

Uso de medicamentos no primeiro trimestre de gravidez: avaliação da segurança dos medicamentos e uso de ácido fólico e sulfato ferroso

Prevalence of medication use among low risk pregnant women: A drug utilization study

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