Avaliação da cobertura do programa de triagem neonatal de hemoglobinopatias em populações do Recôncavo Baiano, Brasil

Hemoglobinopathies, in particular sickle cell disease, is the most prevalent group of genetically transmitted diseases in the Brazilian population and should thus be treated as a public health problem. Many of these patients frequently present with complications and require emergency care at the blood bank Coordinator in Rio de Janeiro. This study was developed with the aim of characterizing the emergency assistance required by sickle cell disease patients registered in the blood bank from January 2007 to December 2008. A retrospective study of medical records was made of 78, mostly children, patients from the date of their registration until December 2009. Most attendances (63.7%) were not considered emergency care. The use of specialized services for cases that do not require this level of complexity may saturate the capacity of these centers. However, delay of intervention for complications due to the transportation of patients to specialist centers may lead to deterioration in the clinical condition.

show abstract

“…Thus wideranging educational programs are needed for professionals in the Family Health Program. (20) …”

Section: Discussionmentioning

confidence: 99%

Emergency care necessity for sickle cell disease patients at Rio de Janeiro State Coordinating Blood Bank

Santoro¹,

Matos²,

Fidlarczyk³

2011

Rev. Bras. Hematol. Hemoter.

View full text Add to dashboard Cite

show abstract

“…Another (11) . However, it is necessary to consider the possibility that these figures might not reveal the real screening situation in Maringá, since the fact that these tests were performed by the private system makes it unfeasible to consider the official data.…”

Section: Discussionmentioning

confidence: 99%

Neonatal Screening Program coverage in Maringá (PR), 2001 to 2006

et al. 2008

View full text Add to dashboard Cite

Objective: To evaluate the National Newborn Screening Program (NNSP) coverage in the city of Maringá, from 2001 to 2006. Methods: This is a cross-sectional research design, which verified the number of live newborns as well as the number of screened children. The study considered the children born in Maringá as well as those born in other cities but living in Maringá. Results: The NNSP did not reach the expected coverage of 100% in Maringá during the first five years of evaluation. There is a need to consider certain particularities when performing data analysis, such as the period and the place of material collection. Conclusion: Changes should be made so as to improve NNSP coverage. Furthermore, the period when the blood sample was drawn should be reconsidered and decentralized with a view to improve health care delivery. Métodos: Se trata de un estudio observacional transversal retrospectivo. Fueron verificados el número de nacidos vivos y el número de niños rastreados, considerando los nacidos vivos en Maringá y los nacidos vivos residentes en Maringá. Resultados: La cobertura del PNTN en Maringá en los cinco primeros años evaluados, no alcanzó el objetivo deseado por el programa, o sea, el 100% de los nacidos vivos. Algunas consideraciones son necesarias en el análisis de los datos, una de ellas es la época y el local en que el material es recolectado. Conclusión: Se sugieren cambios que puedan ayudar a mejorar la cobertura del Programa de Triaje Neonatal, revisar la época de la recolección de la sangre y descentralizarla para ampliar el horizonte de atención.

show abstract

“…Estimates suggest that 250,000 children are born annually with sickle cell anemia worldwide and thus it is among the most important epidemiological genetic diseases in Brazil and the world. (1,2) …”

Section: Introductionmentioning

confidence: 99%

“…(1,2) With modified physicochemical characteristics, the molecules of hemoglobin S suffer polymerization and precipitation, leading to a change in form, a deformity of red blood cells which become sickle-shaped. In this case, the viscosity of the blood increases due to the formation of tactoids.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of sickle cell disease and sickle cell trait in national neonatal screening studies

Lervolino¹,

Baldin²,

Picado³

et al. 2011

Rev. Bras. Hematol. Hemoter.

View full text Add to dashboard Cite

Sickle cell anemia is the best known hereditary blood disorder; there are serious complications associated with the condition. Diagnosis and early intervention reduce morbidity and mortality. These benefits have resulted in the widespread use of newborn screening education programs. In Brazil, the National Neonatal Screening Program established by decree 822/01 included sickle cell disease in the list of diseases tested in the so called "heel prick test". Since then, national studies of the results of this program have been periodically published. To review the literature in order to assess the prevalence of sickle cell trait and sickle cell anemia from data of national neonatal screening studies on hemoglobin S (Hb S). A bibliographic review was carried out using the key words: sickle cell anemia & hemoglobinopathies & neonatal screening & Brazil in the Bireme and SciELO databases. Original Brazilian studies presenting data on prevalence of the sickle cell trait (Hb AS) and sickle cell anemia (Hb SS) based on neonatal screening for Hb S were analysed. Twelve original national studies were identified with prevalences varying from 1.1% to 9.8% for the sickle cell trait and from 0.8 to 60 per 100,000 live births for sickle cell disease in different Brazilian regions. Conclusion: Neonatal screening for Hb S is a very useful method to assess the prevalence of sickle cell trait (Hb AS) and sickle cell anemia (Hb SS) in Brazil. There is a heterogeneous distribution of this disease with the highest prevalence in the northeastern region and the lowest prevalence in the south.

show abstract

Avaliação da cobertura do programa de triagem neonatal de hemoglobinopatias em populações do Recôncavo Baiano, Brasil

Cited by 17 publications

References 3 publications

Emergency care necessity for sickle cell disease patients at Rio de Janeiro State Coordinating Blood Bank

Emergency care necessity for sickle cell disease patients at Rio de Janeiro State Coordinating Blood Bank

Neonatal Screening Program coverage in Maringá (PR), 2001 to 2006

Prevalence of sickle cell disease and sickle cell trait in national neonatal screening studies

Contact Info

Product

Resources

About