Tuberculose: desafio permanente

Co-infecção por Mycobacterium tuberculosis e vírus da imunodeficiência humana: uma análise epidemiológica em Taubaté (SP)

“…In HIV-positive patients, there is a reduction in the number of Th1 lymphocytes themselves, and such patients are therefore much more susceptible to TB than are HIV-negative patients. (6) In the initial phase of the infection, HIV-positive patients typically present CD4 cell counts greater than 200/mm 3 . In such patients, TB presents clinical characteristics similar to those presented by TB in HIV-negative patients.…”

“…In such patients, TB presents clinical characteristics similar to those presented by TB in HIV-negative patients. In the advanced phases of the infection (AIDS), these patients tend to present CD4 cell counts lower than 200/mm 3 , different clinical characteristics (such as negative tuberculin test results and negative sputum testing results), TB in extrapulmonary sites (ganglia, pleura, and pericardium), and (in the pulmonary presentations) there are atypical radiographic findings, such as the infiltrates found in other lung diseases. Therefore, the diagnosis becomes more difficult, increasing the risk of TB transmission.…”

Um estudo retrospectivo dos aspectos epidemiológicos da tuberculose na comunidade do Complexo de Manguinhos localizado em área urbana do Rio de Janeiro, Brasil, 2000-2002

“…Whereas TB incidence is low in certain regions, it is high in southeastern Brazil, and, in poor communities, the dynamic of TB epidemiology can change over the years in accordance with health and social problems. (8) In the first retrospective epidemiological study carried out in the Complexo de Manguinhos (1986-1994), (9) the communities Conjunto Habitacional Provisório 2 and Parque Carlos Chagas were found to present the highest prevalence. In the present study, the incidence in these communities, although still high, was lower then that found in the earlier study, and other communities emerged with similar or higher rates.…”

Cell proliferation and interferon-gamma response to recombinant MBP-3, NarL, MT-10.3, and 16kDa Mycobacterium tuberculosis antigens in Brazilian tuberculosis patients

“…Disease progression prevention through inducement of protective immunity may be achieved through vaccination; however the current available Bacillus Calmette-Guérin (BCG) efficacy is controversial (Colditz et al 1994, Fine 1995 recognition. However, little is known about the reactivity to these antigens in patients from Rio de Janeiro where are described the highest rates of tuberculosis (TB) incidence in Brazil (Hijjar 2005). The 16 kDa molecule is a polypeptide belonging to the α-cristallin family of low molecular weight, heat shock proteins, of which the coding gene (Rv2031c) has been found exclusively in the M. tuberculosis complex (Yuan et al 1998).…”

“…However, little is known about the reactivity to these antigens in patients from Rio de Janeiro where are described the highest rates of tuberculosis (TB) incidence in Brazil (Hijjar 2005). The 16 kDa molecule is a polypeptide belonging to the α-cristallin family of low molecular weight, heat shock proteins, of which the coding gene (Rv2031c) has been found exclusively in the M. tuberculosis complex (Yuan et al 1998).…”