Citologia oncológica, captura de híbridos II e inspeção visual no rastreamento de lesões cervicais

Gontijo, Rodrigo Modesto Gadelha; Derchain, Sophie; Montemor, Eliana Borin Lopes; Sarian, Luís Otávio; Serra, Marcia Milena Pivatto; Zeferino, Luíz Carlos; Syrjänen, Kari

doi:10.1590/s0102-311x2005000100016

Cited by 13 publications

(8 citation statements)

References 22 publications

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“…There was a concentration of studies in women in the Southeast region, followed by South, then Northeast and North, and no reports were found for the Centralwest region. We identifi ed two large groups of longitudinal studies comprising several substudies using the same sample: the Latin American Screening Study (LAMS) 17,23,24,29,30,38,42,50,51,59 and the Ludwig-McGill Study. 20,21,27,33,[45][46][47][48][53][54][55][56][57] Both were prospective cohort studies for expanding the knowledge about incidence, persistence, and regression of HPV infection.…”

Section: Discussionmentioning

confidence: 99%

Prevalência de infecção do colo do útero pelo HPV no Brasil: revisão sistemática

Ayres

Silva

2010

Rev. Saúde Pública

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The cytology techniques available use different classifications leading to different HPV prevalence estimates. However, considering the studies individually according to the detection technique used, the HPV prevalence has increased. HPV16 was the most prevalent type among women, regardless of the cytology result. The concentration of studies in the Southeast region, especially in metropolitan regions, evidences that further investigations are needed to improve information coverage of Brazilian women.

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Section: Discussionmentioning

confidence: 99%

Prevalência de infecção do colo do útero pelo HPV no Brasil: revisão sistemática

Ayres

Silva

2010

Rev. Saúde Pública

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“…Nem sempre resultado alterado corresponde à doença histológica 23 e verificamos que apenas um caso suspeito de carcinoma invasor foi rastreado pela citologia no grupo Adulta, o qual não se confirmou após a avaliação colposcópica. Esta etapa foi realizada em todas as pacientes independente da gravidade da alteração citológica, embora persistam orientações que postergam a análise colposcópica, indicando-a de acordo com a persistência de determinadas alterações citológicas 24 .…”

Section: Discussionunclassified

Características de um grupo de adolescentes com suspeita de neoplasia intra-epitelial cervical

Nascimento¹,

Pires

Gil³

et al. 2005

Rev. Bras. Ginecol. Obstet.

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Objetivo: avaliar a prevalência de alterações citológicas, colposcópicas e histopatológicas observadas no colo uterino de adolescentes com suspeita de neoplasia cervical e as correlações epidemiológicas, compararando com mulheres adultas jovens. Métodos: estudo transversal, retrospectivo de revisão de 366 prontuários de mulheres encaminhadas para esclarecimento diagnóstico com suspeita de neoplasia cervical. As pacientes foram classificadas em dois grupos definidos por idade. O grupo Adolescente foi composto por 129 mulheres de 13 a 19 anos e o grupo Adulta foi composto por 237 mulheres de 20 a 24 anos. Foram calculados razão de prevalência (RP), respectivos intervalos de confiança (IC) a 95% para cada variável, teste χ 2 ou teste exato de Fisher quando aplicável para comparação das proporções. Resultados: a sexarca ocorreu em média aos 15,0 anos no grupo Adolescente e 16,6 anos no grupo Adulta. A chance de diagnóstico de alterações citológicas no primeiro exame realizado (RP=2,61; IC 95%: 2,0-3,4), a condição neoplasia intra-epitelial cervical (NIC) a esclarecer (RP=1,78; IC 95%: 1,26-2,52) e a colposcopia de baixo grau (RP=1,42; IC 95%: 1,08-1,86) foram estatisticamente significantes no grupo Adolescente. A análise histopatológica não mostrou diferenças para qualquer grau de NIC. Entretanto, foram identificados dois casos de carcinoma microinvasor, sendo um em cada grupo, e três casos de carcinoma invasor no grupo Adulta. Conclusão: nosso estudo sugere que o câncer de colo uterino é raro na adolescência, mas verificamos que alterações a ele associadas aconteceram em mulheres muito jovens. A investigação da neoplasia intra-epitelial cervical com a aplicação criteriosa dos mesmos métodos utilizados para a mulher adulta foi apropriada também na adolescência. PALAVRAS-CHAVE:Adolescente; Neoplasia intra-epitelial cervical; Citologia; Colposcopia; Histopatologia ABSTRACT Purpose: to evaluate the prevalence of cytologic, colposcopic and histopathologic alterations observed in the uterine cervix of adolescents with suspected cervical neoplasia and to compare it with young adult women. Methods: a crosssectional, retrospective study that analyzed 366 medical records of females referred to clarify diagnosis of the suspected cervical neoplasia. The patients had been classified into two groups defined by age. The Adolescent group was composed of 129 females between 13 and 19 years and the Adult group was composed of 237 females between 20 and 24 years. Data were analyzed statistically by the prevalence ratio (PR), respective confidence intervals (CI) at 95% for each variable, χ 2 test, or Fisher exact test used to compare proportion. Results: the first sexual intercourse coitarche occurred on average at 15.0 years in the Adolescent group and 16.6 years in the Adult group. The possibility of diagnosis of cytological alterations in the first Papanicolaou smears (PR=2.61; CI 95%: 2.0-3,4), the condition of non-clarified cervical intraepithelial neoplasia (CIN) (PR=1.78; CI 95%: 1.26-2,52), and the colposcopic impressions of l...

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“…We also used other references to compare the results, including studies with general women population. Based on all these references, the HPV prevalence varied from 18% to 34.2%, which gave us a mean prevalence of 25% [14][15][16]. Therefore, for this population, it was estimated a sample size of 352 women.…”

Section: Patients and Clinical Samplesmentioning

confidence: 99%

Prevalence of human papillomavirus types associated with cervical lesions in Sergipe state, Northeastern Brazil: high frequency of a possibly carcinogenic type

et al. 2018

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Persistent infection with high-risk human papillomavirus (HPV) is the main cause of cervical cancer and the prevalence of HPV types varies depending on the geographic region. Therefore, this study assessed the prevalence of HPV types in women with cervical lesions from Sergipe state, Northeastern Brazil. A cross-sectional study was conducted in women with cervical lesions from March to December 2014. These lesions were investigated by PCR and HPV types were identified by DNA sequencing. 432 patients were included, of which 337 patients tested positive for HPV. Eighteen different HPV types were detected, and high-risk HPV types were detected in 69.2%. HPV 16 (63.4%) was the most prevalent HPV type found, followed by HPV 66 (4.6%), HPV 18 (1.6%) and HPV 45 (1.4%). These results highlight the importance of the high prevalence of HPV 66, which is a possibly carcinogenic virus type not covered by the available vaccines. The prevalence of HPV 16 was high in the studied population, reaffirming the importance of young vaccination. However, the high prevalence of HPV 66 found in this study shows the importance of monitoring the diversity of HPV types in different populations and geographic regions to better understand the impacts of current HPV vaccines.

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Citologia oncológica, captura de híbridos II e inspeção visual no rastreamento de lesões cervicais

Cited by 13 publications

References 22 publications

Prevalência de infecção do colo do útero pelo HPV no Brasil: revisão sistemática

Prevalência de infecção do colo do útero pelo HPV no Brasil: revisão sistemática

Características de um grupo de adolescentes com suspeita de neoplasia intra-epitelial cervical

Prevalence of human papillomavirus types associated with cervical lesions in Sergipe state, Northeastern Brazil: high frequency of a possibly carcinogenic type

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