Programa comunitário de hemoglobinopatias: abordagem populacional a partir de doadores de sangue de Bragança Paulista, São Paulo, Brasil

Abstract

Screening programs for hemoglobinopathies target different population groups such as neonates, students, pregnant women, military personnel, recruits, and blood donors. The feasibility and efficiency of these programs basically depend on the population's receptivity, which in turn is related to highly complex economic, psychological, and sociocultural factors. The purpose of this study was to evaluate the population of Bragança Paulista, São Paulo, based on results from the blood donors' group and to compare these results with those previously obtained in a group of students from the same city. The sample consisted of 1,846 donors who had given blood at the São Francisco University Hematology Center, Bragança Paulista, São Paulo, from October 1998 to April 1999. Analysis of the 1,846 donors identified 31 individuals who were hemoglobinopathy carriers (1.68%). The result was quite similar to that obtained in the group of students and demonstrated that the two methods are similar in relation to detection of hemoglobinopathies; however, the blood donor approach is more practical.

Hemoglobin S identification in blood donors: A cross section of prevalence

“…12 In Bragança Paulista (São Paulo, Brazil) a prevalence of 1.68% of hemoglobinopathies and 1.13% of the SCT was found among 1846 blood donors. 13 …”

Evaluation of the presence of anemia and ferritin deficiency in children

“…A maior proporção de crianças com níveis de hemoglobina abaixo de 11,5 g/dL que possuem níveis normais de ferritina também pode ser explicada pela presença de outras anemias comuns na infância como a anemia megaloblástica, onde ocorre a deficiência de ácido fólico e vitamina B12, que são essenciais para o amadurecimento celular, sendo um tipo de anemia carencial, ou as anemias hereditárias que estão entre as doenças mais comuns determinadas geneticamente e possuem frequência comum na população brasileira, com consequente dispersão de genes anormais, que resultam em doenças como hemoglobinopatias e talassemias. (21) Crianças com hemoglobinopatias ou talassemias foram excluídas do presente estudo por meio de questionário preenchido pelos pais. Contudo, é possível que algumas crianças apresentassem traço talassêmico ou falcêmico, o qual é assintomático e pode não ter sido diagnosticado.…”

A new insight into apheresis platelet donation by sickle cell trait carriers: evidences of safety and quality

“…In countries with a high prevalence of the sickle cell trait (SCT), which is often determined by neonatal screening programs, a significant proportion of blood donors may be SCT carriers [1]. In Brazil, for example, where SCT prevalence ranges from 1.1% to 9.8% in the overall population [2], the trait is found in up to 2.48% of blood donors [3][4][5][6][7]. Because individuals with SCT are usually asymptomatic, many of them are unaware of their condition at the time of donation [1].…”