2002
DOI: 10.1590/s0102-311x2002000200010
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: To characterize the action of 2,3,7,

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

1
26
0
2

Year Published

2005
2005
2019
2019

Publication Types

Select...
7
2

Relationship

0
9

Authors

Journals

citations
Cited by 41 publications
(29 citation statements)
references
References 32 publications
1
26
0
2
Order By: Relevance
“…In porcine follicular cells, recent studies indicate a TCDD-induced decrease in estrogen synthesis and that the exposure to the action of AhR or ER blockers (alpha naphthoflavone and 4-OH-tamoxifen respectively) is able to completely reverse the inhibitory effect (Gregoraszczuk 2002). A further report indicates a potentiation of TCDD activity through contemporary exposure to estradiol in mouse ovarian cells, and that this effect can be reversed through exposure to specific ER blockers (Son et al 2002).…”
Section: Ahr Cross-talk With Steroid Hormone Receptorsmentioning
confidence: 97%
“…In porcine follicular cells, recent studies indicate a TCDD-induced decrease in estrogen synthesis and that the exposure to the action of AhR or ER blockers (alpha naphthoflavone and 4-OH-tamoxifen respectively) is able to completely reverse the inhibitory effect (Gregoraszczuk 2002). A further report indicates a potentiation of TCDD activity through contemporary exposure to estradiol in mouse ovarian cells, and that this effect can be reversed through exposure to specific ER blockers (Son et al 2002).…”
Section: Ahr Cross-talk With Steroid Hormone Receptorsmentioning
confidence: 97%
“…The effects of TCDD on porcine steroidogenesis have been described by others and the subject has been reviewed previously (Gregoraszczuk 2002). Therefore, this section will focus on providing an updated and brief overview of the subject including data obtained using other species.…”
Section: Polyhalogenated Arylhydrocarbonsmentioning
confidence: 99%
“…The adverse effects of TCDD include a number of phenomena such as lethality (Blankenship et al, 2003), tumor promotion (Bertazzi et al, 1999;Cole et al, 2003), immunotoxicity (Kerkvliet, 1995;Ahmed et al, 2005), teratogenicity (Couture et al, 1990), and endocrine changes (Gregoraszczuk, 1995;Osteen and Sierra-Rivera, 1997). It is widely accepted that the majority of toxic effects of TCDD in higher organisms are mediated through activation of the cytosolic aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor of the basic helix-loophelix family (Mimura and Fujii-Kuriyama, 2003;Mandal, 2005).…”
mentioning
confidence: 99%