Estresse oxidativo e aumento da apoptose em neutrófilos de cães com azotemia pré-renal

Silva, A.C.R.A.; Almeida, Breno Fernando Martins de; Soeiro, Carolina Soares; Ferreira, Wagner Luis; Lima, Valéria Marçal Felix de; Ciarlini, Paulo César

doi:10.1590/s0102-09352013000100025

Cited by 3 publications

(4 citation statements)

References 21 publications

(13 reference statements)

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“…The TAC between healthy dogs and dogs with prerenal azotemia was compared, showing that the diseased dogs had a lower antioxidant capacity. Moreover, in these animals, there was an acceleration of neutrophil apoptosis, confirming the existence of oxidative stress in azotemic dogs (SILVA et al, 2013). On the other hand, oxidative metabolism should occur in a physiological manner and is part of the immune response against antigens.…”

Section: Biomarkers Of Oxidative Stresssupporting

confidence: 59%

“…The association between oxidative stress and ischemia-reperfusion injury has been extensively discussed in human medicine (SILVA JÚNIOR et al, 2002;KUNZ et al, 2010;SILVA et al, 2013), primarily with the aim to determine the effectiveness of substances with antioxidant potential that can be included in therapeutic procedures. Natural substances containing phenolic derivatives, such as flavonoids, minimize oxidative damage by inhibiting the action of free radicals, preventing lipid peroxidation, and therefore improving endothelial and neuroprotective functions (MENDES, 2012).…”

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

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Oxidative stress in dogs

Russo

Bracarense

2016

SCA

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Reactive oxygen species (ROS), also known as free radicals, are generated during cellular respiration. Under normal conditions, the body has the ability to neutralize the effects of free radicals by using its antioxidant defenses. In the case of an imbalance between oxidants and antioxidants, free radical production exceeds the capacity of organic combustion, resulting in oxidative stress. Of all the cellular components compromised by the harmful effects of ROS, the cell membrane is the most severely affected owing to lipid peroxidation, which invariably leads to changes in the membrane structure and permeability. With lipid peroxidation of the cell membrane, some by-products can be detected and measured in tissues, blood, and other bodily fluids. The measurement of biomarkers of oxidative stress is commonly used to quantify lipid peroxidation of the cell membrane in humans, a species in which ROS can be considered as a cause or consequence of oxidative stress-related diseases. In dogs, few studies have demonstrated this correlation. The present review aims to identify current literature knowledge relating to oxidative stress diseases and their detection in dogs. Key words: Oxidative stress. Lipid peroxidation. Free radicals. Dogs. ResumoNos processos decorrentes da respiração celular, são gerados produtos denominados espécimes reativos de oxigênio (EROS), conhecidos também como radicais livres. Em condições normais, o organismo possui capacidade de neutralizar os efeitos dos radicais livres utilizando suas defesas antioxidantes. Em situações de desequilíbrio entre agentes oxidantes e antioxidantes, a produção de radicais livres excede a capacidade orgânica de neutralização, resultando na condição conhecida como estresse oxidativo. Dentre todos os componentes celulares atingidos pelos efeitos nocivos dos EROS, as membranas celulares são as estruturas mais severamente acometidas, devido à peroxidação lipídica, que leva, invariavelmente, a alterações estruturais e também na sua permeabilidade. Na peroxidação lipídica da membrana celular, alguns subprodutos podem ser detectados e mensurados nos tecidos, sangue e outros fluidos corpóreos. A mensuração de biomarcadores de estresse oxidativo é habitualmente utilizada para quantificar a lipoperoxidação da membrana celular em humanos, espécie onde as EROS podem ser consideradas como causa ou consequência de doenças relacionadas ao estresse oxidativo. Nos cães, alguns poucos estudos demonstram essa correlação. A presente revisão tem como principal objetivo verificar na literatura, onde se encontra atualmente o conhecimento relacionando o estresse oxidativo às doenças em cães bem como as possíveis formas de detecção de biomarcadores na espécie canina. Palavras-chave: Estresse oxidativo. Lipoperoxidação. Radicais livres. Cães.

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Section: Biomarkers Of Oxidative Stresssupporting

confidence: 59%

Section: Biomarkers Of Oxidative Stressmentioning

confidence: 99%

Oxidative stress in dogs

Russo

Bracarense

2016

SCA

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“…In rodents, a decrease in TAC was also observed among obese animals (Bełtowski et al 2000;Furukawa et al 2004). In addition to obesity, oxidative stress has been described in pathologies such as chronic kidney disease (CKD) in dogs (Silva et al 2013), in cats (Keegan and Webb 2010) and in humans (Rysz et al 2004), and in feline infectious peritonitis (Pedersen 2014). In CKD in felines, an increase was detected in reduced glutathione: oxidized glutathione (GSH:GSSG) ratios.…”

Section: Discussionmentioning

confidence: 99%

Feline Obesity Causes Hematological And Biochemical Changes And Oxidative Stress

Martins

Ramos

Possidônio

et al. 2022

Preprint

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Obesity, an extremely important factor in feline clinical practice, is estimated to affect up to one third of the feline population. Moreover, it can trigger chronic inflammation, which could predispose to oxidative stress by increasing reactive oxygen species, thereby generating potentially irreversible cellular damage. This study analyzed hematological, biochemical and oxidative stress profiles at various degrees of feline obesity. Forty-five cats were selected and divided into three groups: control (n=17), overweight (n=13) and obese (n=15), after clinical and laboratory evaluation and body condition score. Biochemical and oxidative stress analyses were performed using a photocolorimeter and hematological analyses were performed in a veterinary cell counter. The hematological profile of obese cats showed increased mean corpuscular volume (MCV) and red cell distribution width (RDW), while their biochemical profile revealed increased HDL cholesterol and triglycerides and decreased activity of gamma-glutamyl transferase (GGT). As for oxidative stress, obese cats showed higher total antioxidant capacity (TAC), by the inhibition of 2,2’-Azino-Bis-3-Ethylbenzthiazoline-6-Sulfonic Acid (ABTS), inhibition of ABTS associated with horseradish peroxidase (ABTS+HRP), cupric ion reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) methods, while overweight cats had a higher TAC-ABTS+HRP and TAC-FRAP. We conclude that the conditions of natural obesity and overweight in the feline species alter its hematological, biochemical and oxidative stress parameters.

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“…Em medicina veterinária alguns estudos demonstram que a ação dessas espécies na homeostase celular pode ser primária ou secundária ao desenvolvimento de enfermidades devido ao efeito cumulativo das injúrias celulares produzidas nessas condições (Curtis, 2013, Silva et al, 2013, Russo & Bracarense, 2016.…”

Section: Introductionunclassified

Estrés oxidativo: fisiopatología y diagnóstico de laboratorio

Campos¹,

Leme

2018

Pubvet

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RESUMO.Estresse oxidativo é um distúrbio metabólico no qual moléculas instáveis, também denominadas espécies reativas, ocasionam injúrias celulares devido a reações de óxido-redução com moléculas orgânicas, tais como fosfolipídios, proteínas e DNA. Essas injúrias podem acarretar perda da função celular e, consequentemente, disfunções importantes nos sistemas orgânicos. Tais espécies são formadas constantemente na fisiologia celular normal, seja através do metabolismo do oxigênio ou dos aminoácidos, gerando, respectivamente, as espécies reativas do oxigênio (EROS) e espécies reativas do nitrogênio (ERNS). Devido ao potencial tóxico dessas moléculas, mecanismos de proteção endógenos e exógenos, representados pelos agentes antioxidantes, entram em ação para neutralizar esses compostos e impedir a injúria celular. Quando a produção dessas espécies excede a capacidade antioxidante do organismo, o metabolismo celular entra em estresse oxidativo. Em certos casos, as produções das EROS e ERNS tornam-se desejáveis, como exemplo nos distúrbios inflamatórios, onde participarão da produção de mediadores inflamatórios, porém a exacerbação dessa produção pode ser prejudicial, sendo importante conhecer o status oxidativo para controlar a progressão do distúrbio em animais enfermos. Neste contexto, é necessário conhecer o perfil bioquímico dos compostos oxidantes e antioxidantes na rotina clínico-hospitalar de pequenos e grandes animais. O presente trabalho objetivou elucidar sobre os mecanismos fisiopatológicos do estresse oxidativo, bem como os métodos de diagnóstico laboratorial disponíveis, para explanar a importância do estresse oxidativo na prática clínica, de modo que a determinação desses compostos seja incluída na rotina médica e hospitalar. Palavras chave: antioxidantes, injúria celular, radicais livresOxidative stress: pathophysiology and laboratory diagnosis ABSTRACT. Oxidative stress is a metabolic disorder in which unstable molecules, also called reactive species, cause cellular injury due to oxidation-reduction reactions with organic molecules, such as phospholipids, proteins and DNA. These injuries can lead to loss of cellular function and, consequently, important dysfunctions in organic systems. These species are constantly formed in the normal cellular physiology, either through the metabolism of oxygen or amino acids, generating, respectively, reactive oxygen species (EROS) and reactive nitrogen species (RNSN). Due to the toxic potential of these molecules, endogenous and exogenous protective mechanisms, represented by the antioxidant agents, come into action to neutralize these compounds and prevent cellular injury. When the production of these species exceeds the antioxidant capacity of the organism, the cellular metabolism enters into oxidative stress. In certain cases, the EROS and ERNS productions become desirable, as an example in inflammatory disorders, where they will participate in the production of inflammatory mediators, but the exacerbation of this production can be detrimental and it is important...

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Estresse oxidativo e aumento da apoptose em neutrófilos de cães com azotemia pré-renal

Cited by 3 publications

References 21 publications

Oxidative stress in dogs

Oxidative stress in dogs

Feline Obesity Causes Hematological And Biochemical Changes And Oxidative Stress

Estrés oxidativo: fisiopatología y diagnóstico de laboratorio

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