Resposta clínica e metabólica de potros neonatos em relação aos achados histopatológicos da placenta na égua

Lins, Laurence; Finger, Ilusca Sampaio; Fernandes, Cristina G.; Curcio, B.R.; Corrêa, Márcio Nunes; Nogueira, Carlos Eduardo Wayne

doi:10.1590/s0102-09352012000600005

Cited by 2 publications

(3 citation statements)

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“…In neonatal foals, serum urea concentrations at birth are within the adult reference range and generally this drops during the following days (Bauer et al, 1984). In this current study, elevated levels of urea in all groups may be considered a singular result of the local population since similar results have been described in a clinical study performed in the same area (Lins et al 2012). Nevertheless, Immature group showed that urea concentrations remain increased at 24h of age which may be attributed to hepatic immaturity rather than to impaired renal function.…”

Section: Discussionsupporting

confidence: 73%

“…The decrease of Hct and increase of TPP levels observed in all groups might be related to absorption of colostral proteins, which enhance plasma volume through osmotic effects (Harvey 1990). Foals of the Immature group showed elevated levels of fibrinogen and this has been reported in foals from placentitis (Lins et al 2012, Feijó et al 2014. Hyperfibrinogenemia in foals less than 2 days of age is an indicator of in utero sepsis and inflammation, since this indicates an inflammatory response at least 24 to 48 hours (Morresey 2005, Axon & Palmer 2008).…”

Section: Discussionmentioning

confidence: 68%

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Hematological and biochemical indicators of maturity in foals and their relation to the placental features

et al. 2018

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Newborn’s health is directly related to gestational conditions and placental efficiency. The aims of this study were: (1) To evaluate hematological and biochemical parameters of foals born from mares with placentitis at birth and at 24h of age, (2) to verify if placental pathology had any influence on neonatal maturity degree through hematological and biochemical response of those foals. According to placental findings (control and placentitis) and neonatal maturity degree (mature and immature), foals were divided into three groups: (1) Control group (n=22), foals born from mares with placentitis and classified as (2) Mature (n=26), and (3) Immature (n=10). The hematocrit and plasma concentration of fibrinogen, total plasma protein, white blood cells count, lactate, glucose, creatinine, urea, albumin, bilirubin, triglyceride, cholesterol, calcium, phosphorus, magnesium, aspartate aminotransferase (AST), creatine kinase (CK), alkaline phosphatase (ALP), and gamma-glutamyltransferase (GGT) were measured. Placental features were significantly different between neonatal maturity degree (P=0.001). Mares that had acute placentitis foaled more immature neonates (n=8/10; 80%). Concentrations of fibrinogen (P=0.003), creatinine (P=0.021), total cholesterol (P=0.014), AST (P=0.001), GGT (P=0.002), total (P=0.001) and unconjugated bilirubin (P=0.010) were higher at birth in the Immature group, whereas albumin levels were lower (P=0.002). Foals born from mares with placentitis presented hyperlactatemia at 24h of age (P=0.002). Acute placentitis had an influence on the neonatal maturity, allowing an accelerated but incomplete fetal maturation. The monitoring of lactate, fibrinogen, creatinine, bilirubin, cholesterol, albumin, AST, and GGT levels, associated with clinical, physical, and behavior evaluation may contribute as indicators of neonatal maturity.

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Section: Discussionsupporting

confidence: 73%

Section: Discussionmentioning

confidence: 68%

Hematological and biochemical indicators of maturity in foals and their relation to the placental features

et al. 2018

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“…O objetivo deste estudo é estabelecer o proteinograma sérico em éguas com placentite induzida e em seus respectivos neonatos. Hong et al (1993) e Lins et al (2012). Foi realizada a comparação do proteinograma sérico entre as éguas com lesões compatíveis com placentite aguda (n=4) contra as éguas que não apresentaram esse padrão de placenta (n=4).…”

Section: Introductionunclassified

Proteinograma sérico de éguas com placentite ascendente e seus respectivos neonatos: dados preliminares

Haetinger¹,

Curcio²,

Lins³

et al. 2016

Arq. Bras. Med. Vet. Zootec.

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RESUMOEste estudo teve por objetivo estabelecer o proteinograma sérico em éguas com placentite induzida e em seus respectivos neonatos. Foram coletadas amostras de sangue das éguas em oito momentos diferentes e dos potros em quatro momentos. Para obtenção da concentração das frações proteicas, utilizou-se eletroforese em gel de acrilaminada contendo dodecil sulfato de sódio (SDS-PAGE). No método utilizado, foram observadas 23 bandas proteicas, cujos pesos moleculares variaram de 16KDa a 245KDa, sendo possível a identificação das seguintes frações: 175KDa, 102KDa, 83KDa, 63KDa, 50KDa, 41KDa, 39KDa e 28KDa. De todas as bandas proteicas encontradas, somente as de 39KDa e 41KDa apresentaram alteração na cinética nos momentos avaliados. De acordo com a solução marcadora, pode-se sugerir que essas proteínas seriam α1-glicoproteína ácida (39KDa) e haptoglobina (41KDa). A concentração de imunoglobulinas nos potros apresentou aumento significativo a partir das 12 horas de nascimento. Não está elucidado se estes níveis refletem a persistência do processo inflamatório placentário ou se são alterações fisiológicas do periparto. Não foram observadas alterações na cinética das proteínas nos potros nas primeiras 48 horas.Palavras-chave: haptoglobina, α1-glicoproteína ácida, obstetrícia equina, proteínas de fase aguda ABSTRACTThe aim of this paper was to identify the serum acute phase protein concentration in mares with induced placentitis and their neonates. Blood samples were collected from the mares in 8 different moments, and from the foals, in 4 moments. To obtain the concentration of protein fractions acrilaminada gel electrophoresis in sodium dodecyl sulfate (SDS-PAGE) was used. In the used method 23 protein bands whose molecular weights ranged from 16kDa to 245kDa were observed, it is possible to identify the following fractions: 175kDa, 102kDa, 83kDa, 63kDa, 50kDa, 41kDa, 39kDa and 28kDa. Of

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Resposta clínica e metabólica de potros neonatos em relação aos achados histopatológicos da placenta na égua

Abstract: Resposta clínica e metabólica de potros neonatos em relação aos achados histopatológicos da placenta na égua [Clinical and

Cited by 2 publications

References 7 publications

Hematological and biochemical indicators of maturity in foals and their relation to the placental features

Hematological and biochemical indicators of maturity in foals and their relation to the placental features

Proteinograma sérico de éguas com placentite ascendente e seus respectivos neonatos: dados preliminares

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