Perfis clínico e hematológico de camundongos submetidos ao envenenamento escorpiônico experimental por Tityus fasciolatus

Guimarães, P.T.C.; Pinto, Maria Benegelânia; Melo, Marília Martins

doi:10.1590/s0102-09352011000600015

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…It is also suggested that changes in hematological parameters are not attributed to the effects caused by the extract, since they are expected changes for the species [ 28 , 29 ]. Some studies have shown that acute induced stress in animals causes the release of catecholamines and recruitment of leukocytes, which induce the increase of cells in the circulation, which was observed in the subchronic toxicity evaluation in the highest dose of the extract [ 30 ].…”

Section: Resultsmentioning

confidence: 99%

In Vivo and In Vitro Toxicity Evaluation of Hydroethanolic Extract of Kalanchoe brasiliensis (Crassulaceae) Leaves

Fonseca

Dantas

Fernandes

et al. 2018

Journal of Toxicology

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The species Kalanchoe brasiliensis, known as “Saião,” has anti-inflammatory, antimicrobial, and antihistamine activities. It also has the quercetin and kaempferol flavonoids, which exert their therapeutic activities. With extensive popular use besides the defined therapeutical properties, the study of possible side effects is indispensable. The objective of this study is to evaluate the toxicity in vitro and in vivo from the hydroethanolic extract of the leaves of K. brasiliensis. The action of the extract (concentrations from 0.1 to 1000 uL/100 uL) in normal and tumor cells was evaluated using the MTT method. Acute toxicity and subchronic toxicity were evaluated in mice with doses of 250 to 1000 mg/kg orally, following recognized protocols. The in vitro results indicated cytotoxic activity for 3T3 cell line (normal) and 786-0 (kidney carcinoma), showing the activity to be concentration-dependent, reaching 92.23% cell inhibition. In vivo, the extract showed no significant toxicity; only liver changes related to acute toxicity and some signs of liver damage, combining biochemical and histological data. In general, the extract showed low or no toxicity, introducing itself as safe for use with promising therapeutic potential.

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Section: Resultsmentioning

confidence: 99%

In Vivo and In Vitro Toxicity Evaluation of Hydroethanolic Extract of Kalanchoe brasiliensis (Crassulaceae) Leaves

Fonseca

Dantas

Fernandes

et al. 2018

Journal of Toxicology

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“…The crude venom toxicity was also evaluated in cardiorespiratory system by electrocardiogram (ECG) in rats, showing that the dose of 2.3 mg/kg induces several cardiorespiratory alterations [ 4 ]. Guimarães et al 2011, demonstrated that at 24 µg, Tityus fasciolatus venom causes piloerection, pain behavior, nasal and oral sharp, dyspnea, facial rash, excessive reflexes, and alteration of the blood profile in mice [ 19 ]. Posteriorly, the immunological response evoked by the T. fasciolatus crude venom was evaluated, and three toxins had their sequences described (Tf1, Tf3, and Tf4a) [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Subtype Specificity of β-Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels

Mata

Tibery

Campos

et al. 2018

Toxins

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Scorpion venoms are a complex mixture of components. Among them the most important are peptides, which presents the capacity to interact and modulate several ion channel subtypes, including voltage-gated sodium channels (NaV). Screening the activity of scorpion toxins on different subtypes of NaV reveals the scope of modulatory activity and, in most cases, low channel selectivity. Until now there are approximately 60 scorpion toxins experimentally assayed on NaV channels. However, the molecular bases of interaction between scorpion toxins and NaV channels are not fully elucidated. The activity description of new scorpion toxins is crucial to enhance the predictive strength of the structural–function correlations of these NaV modulatory molecules. In the present work a new scorpion toxin (Tf1a) was purified from Tityus fasciolatus venom by RP-HPLC, and characterized using electrophysiological experiments on different types of voltage-gated sodium channels. Tf1a was able to modify the normal function of NaV tested, showing to be a typical β-NaScTx. Tf1a also demonstrated an unusual capability to alter the kinetics of NaV1.5.

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Escorpiões de importância médica no Estado da Paraíba, Brasil

Sousa¹,

Silva²,

Sousa³

et al. 2020

evid.

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Entre os agentes tóxicos que podem ameaçar a saúde do homem, os escorpiões são os que mais provocam acidentes em território paraibano. Para o ministério da saúde, quatro espécies do gênero Tityus possuem importância médica no Brasil, devido à sua capacidade de adaptação em ambientes urbanos, reprodução partenogenética e a toxicidade de sua peçonha. O objetivo desse trabalho foi apresentar as espécies de escorpião que possuem importância médica no estado da Paraíba. Trata-se de uma revisão de literatura, descritiva e qualitativa, com base em documentos obtidos nos bancos de dados Scielo, Lilacs, Repositório UnB, Fiocruz e Ministério da Saúde. Foram considerados os documentos publicados no período de 2014 a 2019. Também foram coletados dados de intoxicação disponibilizados pelo SINITOX referentes ao período de 2009 a 2013. Duas espécies são responsáveis pelos acidentes escorpiônicos: T. serrulatus e T. stigmurus, sendo este último considerado o principal agente etiológico no estado. No período de 2009 a 2013, a Paraíba foi o estado da região Nordeste que mais notificou a ocorrência de acidentes envolvendo escorpiões, com 11.243 casos. O maior número de notificações ocorreu em 2012 (2.467) e o menor em 2013 (1.946). Os acidentes escorpiônicos são a principal causa de intoxicações no estado, enquanto no Brasil os medicamentos são os principais responsáveis.

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Perfis clínico e hematológico de camundongos submetidos ao envenenamento escorpiônico experimental por Tityus fasciolatus

Cited by 4 publications

References 19 publications

In Vivo and In Vitro Toxicity Evaluation of Hydroethanolic Extract of Kalanchoe brasiliensis (Crassulaceae) Leaves

In Vivo and In Vitro Toxicity Evaluation of Hydroethanolic Extract of Kalanchoe brasiliensis (Crassulaceae) Leaves

Subtype Specificity of β-Toxin Tf1a from Tityus fasciolatus in Voltage Gated Sodium Channels

Escorpiões de importância médica no Estado da Paraíba, Brasil

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