Feline intraocular sarcoma associated with phthisis bulbi

Abstract

Two cases of feline intraocular sarcoma were reported in stray cats that presented blindness and hypotonia of the affected eye for years before the tumor development. Phthisis bulbi, a final stage of a severe inflammation of the eye, is frequently unmonitored because eyes are blind, small, opaque, and not painful. Yet, this report shows that monitoring and early enucleation of eyes of cats with phthisis bulbi are important and should be considered as a treatment option, because feline intraocular sarcoma is an aggressive tumor that significantly decreases live expectancy.Keywords: feline, phthisis bulbi, intraocular, sarcoma, metastasis RESUMO Relatam-se dois casos de sarcoma ocular em gatos que apresentavam cegueira e hipotonia nos olhos afetados por anos antes do crescimento neoplásico. Phthisis bulbi, que é o estágio final de um processo inflamatório ocular intenso, geralmente não é monitorado por tratar-se de um olho cego

Iris melanoma associated with unilateral phthisis bulbi in a 13-year-old domestic shorthair female cat

“…It had been suggested that chronic intraocular inflammation preceded the development of intraocular sarcoma in these cats (Perlmann et al. 2011). Feline intraocular sarcoma, in fact, affects cats one to ten years from an initial trauma, but also cats with chronic uveitis with no history of trauma (Dubielzig et al.…”

“…Only three cases of ocular tumor associated with phthisis bulbi in cats have been identified in the literature (Perlmann et al. 2011; Woog et al. 1983).…”

“…reported two cases of feline intraocular sarcomas in cats with phthisis bulbi (Perlmann et al. 2011): in these cases, the diagnosis was based on the immunohistochemical results (negative for CD3, CD79a, cytokeratin, and S-100, and positive for vimentin). It had been suggested that chronic intraocular inflammation preceded the development of intraocular sarcoma in these cats (Perlmann et al.…”

“…In these above-mentioned cases of feline ocular neoplasm associated with phthisis bulbi a significantly reduced life expectancy for affected cats was reported, but, unfortunately, the lack of diagnostic imaging at follow-up or necropsy did not permit an adequate assessment of tumor metastatic behavior (Perlmann et al. 2011; Woog et al. 1983).…”

“…However, neurologic symptoms occurred briefly after surgery and a central nervous system invasion by neoplastic cells from the eye was suspected (Perlmann et al. 2011; Woog et al. 1983).…”