Perfis eletrocardiográfico e ecodopplercardiográfico de ovinos após ingestão da suspensão aquosa de Mascagnia rigida Griseb. (Malpighiaceae).

Lago, Eduardo; Melo, M. M.; Araújo, Roberto Baracat de; Nascimento, Edisa Ferreira Inocêncio; Silva, E.F.; Melo, Manuel

doi:10.1590/s0102-09352009000400012

Cited by 12 publications

(16 citation statements)

References 18 publications

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“…The same results were also demonstrated in sheep intoxicated by this plant (4). These alterations may be caused by the great variability of the vagal mechanisms and extreme mobility of the rabbit heart, which produces inevitable changes in placement (24) and, consequently, of the electrical axis of the heart or intrinsic electrochemical changes of the heart itself (21).…”

Section: Time (T) Groupssupporting

confidence: 67%

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Cardiac evaluation after experimental intoxication by Amorimia rigida (Malpighiaceae) extracts in rabbits

Borboleta¹,

Ef²,

Oliveira³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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Clinical and laboratory changes were evaluated in rabbits after intoxication by Amorimia rigida, a plant that causes sudden death. Nine New Zealand male rabbits, averaging 3.54 kg, were categorized into three groups (n = 3) and received, for eight consecutive days, the equivalent of 30 g/kg dry matter of A. rigida water-soluble (SG) and water-insoluble (IG) extracts via nasoesophageal route. The control group received water. There were no alterations in creatine kinase enzyme (CK), CK myocardial fraction (CKMB) or troponine I (cTnI). None of the animals had clinical or electrocardiographic (conventional and Holter) alterations. There were progressive decreases in the left ventricular ejection fraction and systolic fractional shortening. Doppler echocardiography alterations suggested a systolic dysfunction in the SG and IG groups and diastolic dysfunction in IG group. It was concluded that the soluble and insoluble extracts of A. rigida cause deficit of cardiac function.Key words: toxic plant, Amorimia rigida, cardiac muscle profile, electrocardiography, echocardiography, rabbit. Original PaPer The Journal of Venomous Animals and Toxins including Tropical Diseases ISSN 1678-9199 | 2012 | volume 18 | issue 3 | pages 295-305 INTRODUCTIONThe genus Amorimia (Malpighiaceae) contains one of the 10 most important toxic plants in South America (1), best known of which is Amorimia rigida (Mascagnia rigida), well distributed in Minas Gerais state (Brazil), mainly in the northern and northeastern regions, where it is popularly known as "salsa-rosa" or "suma-roxa". It belongs to a group that causes acute intoxication that may provoke death preceded or not by a short period of clinical signs (2).After A. rigida intake, animals may show apathy, anorexia, rigid walking, prolonged recumbence, muscle tremors and death, among other clinical signs. Significant alterations have not been found at necropsy of animals intoxicated by A. rigida. Multifocal infiltrate of lymphocytes in the myocardium associated with edema and congestion of myocytes was found in the histological exams (3).Studies are necessary to elucidate which physiopathological mechanisms are involved in A. rigida intoxication that leads to sudden death. In spite of the existence of some reports of mortality in the absence of cardiac lesions, it is suggested that the main action of this plant in the heart may be due to its phytochemical characteristics that might affect cardiac function within a period insufficient to produce alterations detectable by optical microscopy (4).To the best of our knowledge, no previous study has concurrently evaluated continuous electrocardiography (Holter), Doppler echocardiography and the cardiac muscle biochemical profile in animals after the intake of A. rigida. Thus, the present work aimed to ascertain the influence of this plant on the cardiac system using the rabbit as the experimental model. MATERIALS AND METHODS Animal AssaysNine six-month-old white New Zealand male rabbits weighing an average of 3.54 kg were used. Firstl...

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Section: Time (T) Groupssupporting

confidence: 67%

“…In spite of the existence of some reports of mortality in the absence of cardiac lesions, it is suggested that the main action of this plant in the heart may be due to its phytochemical characteristics that might affect cardiac function within a period insufficient to produce alterations detectable by optical microscopy (4).…”

Section: Introductionmentioning

confidence: 99%

Cardiac evaluation after experimental intoxication by Amorimia rigida (Malpighiaceae) extracts in rabbits

Borboleta¹,

Ef²,

Oliveira³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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“…A. rigida é a Malpighiaceae mais conhecida, difundida e importante de toda a região nordeste do país (Duarte et al 2013b). Têm provocado surtos de intoxicações principalmente em bovinos (Medeiros et al 2002, Silva et al 2006, Vasconcelos et al 2008b) e menos freqüentemente em caprinos (Oliveira et al 1978) e ovinos (Pacífico da Silva et al 2008, Lago et al 2009.…”

Section: Introductionunclassified

Fibrose cardíaca associada à intoxicação por Amorimia septentrionalis em bovinos

et al. 2014

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Eight cattle were necropsied. Tissues were collected from abdominal and thoracic cavities, besides brain and spinal cord. The clinical changes consisted in apathy, prolonged sternal recumbency, reluctance to move, fatigue, tachypnea, tachycardia and positive venous pulse. The animals that were forced to move showed instability, muscular tremors and then a single fall followed by vocalizations, paddling and death in 5-7 minutes. Macroscopic changes consisted in pulmonary edema, globular heart with whitish areas, petechiae and ecchymosis in the epicardium, myocardium and papillary muscles. Microscopically there was an increase of eosinophilia of cytoplasm of cardiomyocytes, picnosis, cariorrexia, karyolysis, loss of striations and multifocal areas of cardiac fibrosis. In the kidney, there was hydropic vacuolar degeneration and necrosis of epithelial cells in convoluted tubules. The clinical signs presented by the cattle poisoned were similar to those previously described by plants containing MFA. The macroscopic and microscopic lesions described in the heart and kidneys are of great diagnostic value. A. septentrionalis is the main toxic plant of livestock interests in the studied regions due to direct and indirect economic losses in livestock that causes. INDEX TERMS: Poisonous plants, Amorimia septentrionalis, plant poisoning, sudden death, MFA, cardiac fibrosis, cattle.

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“…A comparação dos valores por nós obtidos com aqueles considerados referência para ovinos, 37,2% (Moses & Ross 1987), 42% (Dodic et al 2001) e 40% (Rabbani et al 2006), permite clara evidenciação do comprometimento da função cardíaca induzido pelo MF. Achados similares (FE = 32,4% e 29,5%) foram recentemente descritos em ovinos intoxicados com 20g/kg de M. rigida (Lago et al 2009). De acordo com alguns autores, a redução da fração de encurtamento ocorre nas fases iniciais da insuficiência cardíaca e indicam alterações de ordem ventricular (Kittleson & Kienle 1998, Silva et al 2008.…”

Section: Discussionunclassified

Avaliações clínico-patológicas e laboratoriais da intoxicação experimental por monofluoroacetato de sódio em ovinos

et al. 2010

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O objetivo deste trabalho foi verificar se a administração de doses únicas e de frações diárias da dose letal de monofluoroacetato de sódio (MF) a ovinos induzem a clássica degeneração hidrópico-vacuolar (DHV) dos túbulos uriníferos contornados distais observada no rim de bovinos intoxicados por plantas brasileiras que causam "morte súbita" (PBCMS). MF foi administrado, por via oral, em doses únicas de 0,5 e 1,0mg/kg, cada dose para dois ovinos, e em doses subletais repetidas diariamente de 0,1mg/kg/dia, por quatro dias, e 0,2mg/kg/dia por seis dias, cada dose para um ovino. Todos os ovinos que receberam MF morreram, exceto um que recebeu 0,5mg/kg e não mostrou sintomas. A evolução da intoxicação variou de 3min a 33h5min. Clinicamente os animais apresentaram taquicardia, respiração abdominal, tremores musculares, ligeira perda de equilíbrio, por vezes cambaleavam, deitavam e apoiavam a cabeça no flanco. Na fase final, os ovinos caíam em decúbito lateral, esticavam os membros, faziam movimentos de pedalagem, apresentavam opistótono e morriam. O exame ecocardiográfico evidenciou dilatação cardíaca e redução da fração de encurtamento sistólico. A análise dos níveis séricos de uréia e creatinina revelou moderada a acentuada azotemia. MF provocou "morte súbita" em todos os ovinos que mostraram sintomas. À necropsia verificaram-se aurículas e veias jugulares, cavas, ázigos e pulmonares moderadamente ingurgitadas e, em alguns animais, edema pulmonar. O exame histopatológico revelou, em todos os ovinos, leve a acentuada DHV das células epiteliais dos túbulos contornados distais, associada à picnose nuclear. Adicionalmente, verificaram-se discreta vacuolização e, por vezes, necrose de coagulação de hepatócitos. Não encontramos referências a esse tipo peculiar de lesão, exceto das descrições sobre lesões renais associadas à ingestão de PBCMS e de recentes estudos em bovinos intoxicados com MF. Este trabalho demonstra, em ovinos, que tanto doses letais únicas quanto subdoses diárias de MF induzem a DHV dos túbulos uriníferos contornados distais associada à picnose nuclear.

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Perfis eletrocardiográfico e ecodopplercardiográfico de ovinos após ingestão da suspensão aquosa de Mascagnia rigida Griseb. (Malpighiaceae).

Cited by 12 publications

References 18 publications

Cardiac evaluation after experimental intoxication by Amorimia rigida (Malpighiaceae) extracts in rabbits

Cardiac evaluation after experimental intoxication by Amorimia rigida (Malpighiaceae) extracts in rabbits

Fibrose cardíaca associada à intoxicação por Amorimia septentrionalis em bovinos

Avaliações clínico-patológicas e laboratoriais da intoxicação experimental por monofluoroacetato de sódio em ovinos

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