Meningoencephalitis in a horse associated with equine herpesvirus 1

Costa, Érica Azevedo; Lima, Gabriella Breder Lara; Castro, R.T.; Furtini, Ronaldo; Portilho, R. V.; Resende, Maria Aparecida de

doi:10.1590/s0102-09352008000600044

Cited by 5 publications

(3 citation statements)

References 13 publications

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“…The neurological signs observed in hamsters inoculated with the EHV-1 variants tested were similar to those described after natural infection in the host equine species: lethargy, anorexia, and ataxia reaching peak intensity at 2-3 dpi [41][42][43]. Meningeal congestion was the only macroscopic alteration in brain of the inoculated hamsters, this alteration has also been observed in mice and horses as a result of EHM, associated with congestion and hemorrhagic foci in spinal cord [7,8,18].…”

Section: Discussionsupporting

confidence: 67%

Evaluation of Viral Migration of Different Variants of Equid Alphaherpesvirus 1 in the Central Nervous System of Hamsters by Immunohistochemistry

Silva¹

2019

AVS

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The intranasal inoculation of equid alphaherpesvirus1 (EHV-1) Brazilian variants A4/72, A9/92, A3/97, Iso72/10 and the Argentine variant AR4 in a Syrian hamster model Mesocricetus auratus induced severe encephalitis. Clinical signs included weight loss, lethargy, somnolence, anorexia, and intense salivation two days post-inoculation (dpi), followed by neurological signs such as loss of proprioception, walking in circles, spastic paralysis, seizures, recumbency and death at 3 rd dpi (A9/92 and A4/72 variants) and 4 th dpi. Respiratory signs such as dyspnea and serosanguinous nasal discharge were also observed. Histopathological changes in brain included mixed inflammatory infiltrate with predominance of mononuclear cells, neuronal degeneration, liquefactive necrosis, hemorrhagic foci, leptomeningitis, perivascular edema, mononuclear infiltration, and perivascular cuffing. Immunohistochemical examination showed viral replication in neurons restrict predominantly to olfactory bulb and frontal cortex (variants AR4 and A3/97) and in groups of cells from distant regions, such as the caudal diencephalon and rostral mesencephalon (variants Iso72/10) and absence of viral antigen labeling of variants A9/92 and A4/72 despite these variants were the most neurovirulent, so new experiments not staggered in days but in hours post inoculation are needed to better understand the viral migration of these variants.

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Section: Discussionsupporting

confidence: 67%

Evaluation of Viral Migration of Different Variants of Equid Alphaherpesvirus 1 in the Central Nervous System of Hamsters by Immunohistochemistry

Silva¹

2019

AVS

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“…The endogenous fragment of 225 bp (IGF-1) was consistently detected in all 75 samples. The positive control used in this study was the first neurological strain of EHV-1 detected in Minas Gerais, previously designated as strain Bucareste 24 .…”

Section: Ehv-1 and Ehv-4 Prevalence Determined By Semi-nested Pcr Assaymentioning

confidence: 99%

Aspectos epidemiológicos e clínicos da infecção neurológica associada ao herpesvírus eqüino 1 (ehv-1) em cavalos que morreram com sinais nervosos no Estado de Minas Gerais, Brasil

Costa

Vasconcelos

Bomfim

et al. 2009

Braz. J. Vet. Res. Anim. Sci.

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“…In Brazil, EHV-1-related infections were reported in the states of Sao Paulo, Minas Gerais, and Rio Grande do Sul and were associated with abortions or clinical neurological manifestations in horses [12]. In addition, there is a report of EHV-5 associated with equine multinodular pulmonary fibrosis in a mare from Rio Grande do Sul [13].…”

Section: Introductionmentioning

confidence: 99%

Detection of Equid gammaherpesvirus 2 and 5 DNA in the upper respiratory tract of asymptomatic horses from Southern Brazil

et al. 2019

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Equid gammaherpesvirus 2 (EHV-2) and 5 (EHV-5) are members of the Herpesviridae family and have been reported in horse populations worldwide. This study aimed to evaluate the presence of herpesvirus DNA in the upper respiratory tract of horses. Twenty-six nasal swabs were collected from asymptomatic adult horses of two different horse farms (A, n = 18; B, n = 8), both located in Southern Brazil. The EHV-1, EHV-2, EHV-4, and EHV-5 DNA analyses were performed using nested PCR assays targeting the glycoprotein B gene. Four (15.3%) and 12 (46.1%) of the 26 nasal swab samples were positive for the EHV-2 and EHV-5, respectively. Four (15.3%) horses were detected with both viruses simultaneously. DNA of EHV-2 and EHV-5 in both single and mixed infections was identified in horses from both herds. All swab samples were negative for EHV-1 and EHV-4. This study reports the first detection of EHV-2 and EHV-5 in the upper respiratory tracts of horses in Brazil. The high detection rate of EHV-2 and EHV-5 in asymptomatic adult horses demonstrates that these gammaherpesviruses are circulating in Brazil.

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Meningoencephalitis in a horse associated with equine herpesvirus 1

Abstract: Communication [Comunicação] Meningoencephalitis in a horse associated with equine herpesvirus 1 [Meningoencefalite em um cavalo associado com herpesvírus eqüino 1]

Cited by 5 publications

References 13 publications

Evaluation of Viral Migration of Different Variants of Equid Alphaherpesvirus 1 in the Central Nervous System of Hamsters by Immunohistochemistry

Evaluation of Viral Migration of Different Variants of Equid Alphaherpesvirus 1 in the Central Nervous System of Hamsters by Immunohistochemistry

Aspectos epidemiológicos e clínicos da infecção neurológica associada ao herpesvírus eqüino 1 (ehv-1) em cavalos que morreram com sinais nervosos no Estado de Minas Gerais, Brasil

Detection of Equid gammaherpesvirus 2 and 5 DNA in the upper respiratory tract of asymptomatic horses from Southern Brazil

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