Proteinograma sérico de veados-catingueiro (Mazama gouazoubira) criados em cativeiro obtido por eletroforese em gel de agarose e de poliacrilamida (SDS PAGE)

Santana, A. M.; Fagliari, José Jurandir; Camargo, Clara M.S.; Santana, A. E.; Duarte, José Maurício Barbanti; Silva, P.R.L.

doi:10.1590/s0102-09352008000600039

Cited by 3 publications

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References 5 publications

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“…Moreover, in the dehydration process, total protein concentration is augmented [37]. Proteins have many functions in the organism and their levels helps in the diagnosis and prognosis of hydration status, inflammation, infection, nutritional status and changes in protein synthesis [38]. In this study, the absolute values of total protein showed no differences among times and groups (Additional file 1), suggesting that hematological changes are likely related to postoperative stress and euthanasia.…”

Section: Resultsmentioning

confidence: 70%

Systemic effects induced by intralesional injection of ω-conotoxin MVIIC after spinal cord injury in rats

Oliveira

Silva

Lavor

et al. 2014

J Venom Anim Toxins incl Trop Dis

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BackgroundCalcium channel blockers such as conotoxins have shown a great potential to reduce brain and spinal cord injury. MVIIC neuroprotective effects analyzed in in vitro models of brain and spinal cord ischemia suggest a potential role of this toxin in preventing injury after spinal cord trauma. However, previous clinical studies with MVIIC demonstrated that clinical side effects might limit the usefulness of this drug and there is no research on its systemic effects. Therefore, the present study aimed to investigate the potential toxic effects of MVIIC on organs and to evaluate clinical and blood profiles of rats submitted to spinal cord injury and treated with this marine toxin. Rats were treated with placebo or MVIIC (at doses of 15, 30, 60 or 120 pmol) intralesionally following spinal cord injury. Seven days after the toxin administration, kidney, brain, lung, heart, liver, adrenal, muscles, pancreas, spleen, stomach, and intestine were histopathologically investigated. In addition, blood samples collected from the rats were tested for any hematologic or biochemical changes.ResultsThe clinical, hematologic and biochemical evaluation revealed no significant abnormalities in all groups, even in high doses. There was no significant alteration in organs, except for degenerative changes in kidneys at a dose of 120 pmol.ConclusionsThese findings suggest that MVIIC at 15, 30 and 60 pmol are safe for intralesional administration after spinal cord injury and could be further investigated in relation to its neuroprotective effects. However, 120 pmol doses of MVIIC may provoke adverse effects on kidney tissue.

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Section: Resultsmentioning

confidence: 70%

Systemic effects induced by intralesional injection of ω-conotoxin MVIIC after spinal cord injury in rats

Oliveira

Silva

Lavor

et al. 2014

J Venom Anim Toxins incl Trop Dis

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Acute phase protein profile in agoutis (Dasyprocta azarae; Lichtenstein, 1823) in captivity, determined by sodium dodecyl sulfate polyacrilamyde gel electrophoresis

et al. 2012

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Mazama gouazoubira(Cetartiodactyla: Cervidae)

Silva-Caballero

Ortega

2022

Mammalian Species

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Mazama gouazoubira (Fischer [von Waldheim], 1814) is an ungulate commonly called gray brocket deer. Six morphological forms have been described, but it is currently considered as monotypic. It is a widespread medium-sized cervid, sexually dimorphic with males having antlers. The geographic distribution of M. gouazoubira extends from the southern Amazon region to northern Argentina and Uruguay and stretches from east of the dry Andean range in Argentina and Bolivia, to the Atlantic Coast. It is the most abundant species of brocket deer in South America. Habitat loss and hunting are considered the major threats and it is listed as “Least Concern” (LC) by the International Union for Conservation of Nature (IUCN).

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Proteinograma sérico de veados-catingueiro (Mazama gouazoubira) criados em cativeiro obtido por eletroforese em gel de agarose e de poliacrilamida (SDS PAGE)

Cited by 3 publications

References 5 publications

Systemic effects induced by intralesional injection of ω-conotoxin MVIIC after spinal cord injury in rats

Systemic effects induced by intralesional injection of ω-conotoxin MVIIC after spinal cord injury in rats

Acute phase protein profile in agoutis (Dasyprocta azarae; Lichtenstein, 1823) in captivity, determined by sodium dodecyl sulfate polyacrilamyde gel electrophoresis

Mazama gouazoubira(Cetartiodactyla: Cervidae)

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